A5100786577- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- T-cell and Retrovirus Studies
- Transplantation: Methods and Outcomes
- Peptidase Inhibition and Analysis
- Systemic Sclerosis and Related Diseases
- interferon and immune responses
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- Organ and Tissue Transplantation Research
- COVID-19 Clinical Research Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
Hirosaki University
2015-2024
Osaka University
2007
Background. Chronic low oxygen in the tubulointerstitial area is a crucial cause of renal degradation and damage. Previous reports have suggested that maintenance blood flow plays role suppression progressive Neovascularization important for flow. We studied production angiogenic factors by culturing proximal tubular epithelial cells (PTEC) under hypoxic conditions. Methods. Cultured PTEC were exposed to normal low-oxygen The levels angiogenin (ANG) vascular endothelial growth factor (VEGF)...
We aimed to evaluate the seroprevalence and investigated factors associated with seropositivity after second SARS-CoV-2 mRNA vaccination in kidney transplant (KT) recipients. This retrospective study conducted between June November 2021 included 106 KT recipients 127 healthy controls who received dose of BNT162b2 vaccine at least 7 days before measurement antibody titers. The titer against receptor-binding domain spike (S) protein was determined. compared rates (immunoglobulin G [IgG] level...
Bronchial epithelial cells play an important role in airway host defence, and interferon (IFN)-gamma controls immune reactions by regulating the expression of various genes bronchial cells. Signal transducer activator transcription 1 (STAT1) is key transcriptional factor IFN-gamma signalling. Retinoic acid-inducible gene-I (RIG-I) a member DExH box family proteins designated putative RNA helicase. helicases diverse roles regulation gene cellular functions, RIG-I implicated antiviral...
The goal of the study was to investigate quality life (QOL) in adult patients with minimal change nephrotic syndrome (MCNS) and test relationship QOL level self-care.We distributed two questionnaires 30 outpatients MCNS. MOS 36-item Short Form Health Survey (SF-36v2) used examine health-related comparison normative data from general Japanese population a chronic diseases. SF-36v2 consists 36 questions classified into 8 subscales. We also Self-Care Behavior Scale for kidney disease (CKD),...
Background. Glomerular crescents play an important role in progressive glomerular injury. The lesions consist of epithelial cells, macrophages and deposits fibrin extracellular matrix. Monocyte chemoattractant protein-1 (MCP-1) macrophage inflammatory protein-2 (MIP-2) are members chemokine subfamilies. MCP-1 MIP-2 potent leukocyte cytokines, they may be involved crescent formation. Thrombin participates We hypothesized that thrombin stimulates the production by cells (GECs). Methods....
Abstract We aimed to evaluate the humoral response after second and third doses of SARS-CoV-2 mRNA vaccine in ABO blood type incompatible kidney transplant (KT) recipients treated with rituximab. This retrospective study conducted between June 2021 2022 included 131 KT 154 nontransplant controls who had received vaccines. compared seropositivity (anti-SARS-CoV-2 spike IgG antibody titer ≥ 0.8 U/mL) vaccinations. Furthermore, we evaluated impact pretransplant vaccination for seropositivity....
Myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) and concurrent membranous nephropathy (MN) are very rare combination. Their causal relationship has been suggested, but not determined. A 73-years-old male with 5-year history of proteinuria underwent an operation for his sigmoid colon cancer. Seven months later, he was referred to a nephrology division due exacerbating renal function hypoalbuminemia. Laboratory examination revealed positive...
Abstract Myeloperoxidase (MPO) anti-neutrophil cytoplasmic Ab (ANCA)–associated vasculitis results from autoimmunity to MPO. IL-17A plays a critical role in generating this form of autoimmune injury but its cell origin is uncertain. We addressed the hypothesis that IL-17A–producing γδ T cells are nonredundant requisite development MPO and glomerulonephritis (GN). studied MPO-ANCA GN wild type, αβ, or cell–deficient (C57BL/6, βTCR−/−, δTCR−/− respectively) mice. Both populations played...
SUMMARY Aim: Matrix metalloproteinases (MMP) affect matrix remodelling, and extracellular metalloproteinase inducer (EMMPRIN) has been reported to increase the levels of several MMP. However, expression EMMPRIN in human kidney its regulatory mechanisms are not well known. In this study, we examined with biopsied specimens, cultured proximal tubular epithelial cells (PTEC) mesangial (HMC). Methods: was by immunofluorescent (IF) reverse transcription polymerase chain reaction, western blotting...
Neutrophil elastase, one of the proteinases released by neutrophils, plays an important role at sites inflammation and was reported to be involved in pathogenesis glomerulonephritis. Sivelestat is a selective neutrophil elastase inhibitor used for acute lung injury associated with systemic inflammatory response syndrome. There have been few reports on effects sivelestat renal disease.In male Wistar rats, anti-Thy1.1 nephritis induced injection antibody. The rats were divided into four...
Paroxysmal nocturnal hemoglobinuria is an acquired disorder of hemopoiesis and characterized by recurrent episodes intravascular hemolysis due to increased sensitivity complement-mediated hemolysis. Systemic lupus erythematosus with paroxysmal very rare. We report a case that developed in patient systemic nephritis. A 29-year-old Mongolian woman had erythematosus, which manifested only as skin lesions when she was 12 years old. She leg edema proteinuria 23 old, renal biopsy revealed...
Chronic renal disease with elevated level of serum creatinine (Cr) often progresses to end-stage disease. Although blockade the renin-angiotensin system has been shown slow progression chronic disease, it remains uncertain whether one could expect such a renoprotective effect even when treatment is initiated late in course The purpose present study was examine losartan, an angiotensin-II receptor antagonist, on advanced insufficiency. We retrospectively analyzed eight hypertensive patients,...
Purpose Patients with hepatitis C virus (HCV)-associated glomerulonephritis in whom HCV RNA was not detected the blood have been reported. We attempted to uncover differences between RNA-negative and RNA-positive cases. Methods The clinical pathological findings for 5 patients HCV-associated without were compared those 23 glomerulonephritis. Results cases characterized by advanced age, female dominance, no cryoglobulinemia glomerular deposition of IgG cases, although observed amount urinary...