A5050795724- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Systemic Lupus Erythematosus Research
- Gout, Hyperuricemia, Uric Acid
- Hepatitis C virus research
- Muscle and Compartmental Disorders
- Fatty Acid Research and Health
- Blood Coagulation and Thrombosis Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Liver Disease Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Alcohol Consumption and Health Effects
- Renin-Angiotensin System Studies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Metabolism and Genetic Disorders
- Complement system in diseases
- T-cell and B-cell Immunology
- Case Reports on Hematomas
- interferon and immune responses
- Vasculitis and related conditions
- Neurological Disorders and Treatments
- Biomedical Research and Pathophysiology
Hirosaki University
2015-2024
Hirosaki University Hospital
2014-2021
University of Colorado Denver
2009-2015
University of Florida
2009-2010
University of Colorado Health
2010
Suntory (Japan)
2005
Background.Recent studies suggest that CD80 (also known as B7.1) is expressed on podocytes in minimal-change disease (MCD) and may have a role mediating proteinuria. expression to be induced by Toll-like receptor (TLR) ligands dendritic cells. We therefore evaluated the ability of TLR induce human cultured podocytes.
Background. Chronic low oxygen in the tubulointerstitial area is a crucial cause of renal degradation and damage. Previous reports have suggested that maintenance blood flow plays role suppression progressive Neovascularization important for flow. We studied production angiogenic factors by culturing proximal tubular epithelial cells (PTEC) under hypoxic conditions. Methods. Cultured PTEC were exposed to normal low-oxygen The levels angiogenin (ANG) vascular endothelial growth factor (VEGF)...
Uric acid has been reported to be a risk factor for the development of chronic kidney disease; however, no study examined whether uric may confer acute injury.We investigated relation between serum and incidence postoperative injury in patients undergoing high-risk cardiovascular surgery (cardiac valve aneurysm surgery).Following surgery, 18 58 (31%) developed injury, with 11 24 (45.8%) elevated group (defined as >6 mg/dl) 7 34 (20.5%) normal (p = 0.05). After controlling baseline renal...
BackgroundWe have reported that children with biopsy-proven minimal change disease (MCD) express CD80 (also known as B7.1) in their podocytes and excrete high levels of urine during active nephrotic syndrome. We also polyIC, a Toll-like receptor 3 ligand, increases mRNA protein expression cultured human dose-dependently, actin re-organization reduction synaptopodin expression.
Hibernating animals develop fatty liver when active in summertime and undergo a switch to fat oxidation state the winter. We hypothesized that this might be determined by AMP dominance of opposing effects: metabolism through deaminase (AMPD2) (summer) activation AMP-activated protein kinase (AMPK) (winter). Liver samples were obtained from 13-lined ground squirrels at different times during year, including summer multiples stages winter hibernation, synthesis β-fatty acid evaluated. Changes...
Background An enhanced renin-angiotensin system causes hypertensive renal damage. Factor Xa not only functions in the coagulation cascade but also activates intracellular signaling through protease-activated receptors ( PAR ). We investigated effects of rivaroxaban, a factor inhibitor, on damage mice overexpressing renin (Ren-TG). Methods and Results The 12- to 16-week-old Ren-TG wild-type were orally administered with or without 6 12 mg/kg rivaroxaban for 1 4 months. Plasma was...
Lung cancer is the leading cause of cancer-related death worldwide. Epidermal growth factor receptor (EGFR) - tyrosine kinase inhibitor (TKI) used for patients with EGFR-mutant lung cancer. Recently, phase III studies in demonstrated that EGFR-TKI monotherapy improved progression-free survival compared platinum-doublet chemotherapy. The echinoderm microtubule-associated protein-like 4 (EML4) anaplastic lymphoma (ALK) fusion oncogene represents one newest molecular targets non-small cell...
The pathogenesis of cardio-vascular disease (CVD) in hemodialysis (HD) patients involves inflammation and oxidative stress. High-sensitivity C-reactive protein (hs-CRP) is an established inflammatory biomarker associated with CVD. Several studies have suggested that the pentraxin-3 (PTX-3) stress-related soluble lectin-like low-density lipoprotein receptor-1 (sLOX-1) are novel biomarkers for CVD non-HD populations. This study aimed to clarify association these future cardiovascular (CV)...
Coupling factor 6 (CF6), a component of adenosine triphosphate (ATP) synthase, is circulating and functions as an endogenous vasoconstrictor by inhibiting cytosolic phospholipase A 2 . We showed high plasma level CF6 in human hypertension. The present study focused on the identification characterization receptor for its post-receptor signaling pathway. Incubation umbilical vein endothelial cells (HUVECs) with excess free reduced 50% immunoreactivity antibody to β-subunit ATP synthase at cell...
We hypothesized that positive fluid balance (FB) is the result of intraoperative kidney injury and associated renal vasoconstriction, therefore may be an early clinical indicator acute (AKI). Since rapid changes in volume occur during cardiovascular (CV) surgery, we investigated influence immediate postoperative FB on AKI.Data from Nesiritide Study were retrospectively analyzed to investigate association between AKI.Patients classified into a negative (NegFB, median -1,221 ml, IQR -1,974...
Phosphate toxicity is an important determinant of mortality in patients with chronic kidney disease (CKD), particularly those undergoing hemodialysis treatments. CKD are advised to take a low phosphate-containing diet, and additionally prescribed phosphate-lowering drugs. Since these usually seek guidance from their physicians nurses for dietary options, we conducted survey determine the levels awareness regarding high phosphate content commercially processed food drinks among medical...
Hyperphosphatemia is an important determinant of morbidity and mortality in patients with chronic kidney disease (CKD). Patients CKD are advised to consume a low phosphate diet often prescribed phosphate-lowering drug therapy. However, commercially processed food drinks contain compounds, but the level not usually provided ingredient list, which makes it difficult for choose correct diet. We conducted survey awareness food/beverages containing artificially added among undergoing...