A5056841187- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Ion Transport and Channel Regulation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Kidney Disease and Diabetes
- Urological Disorders and Treatments
- Complement system in diseases
- Dialysis and Renal Disease Management
- Electrolyte and hormonal disorders
- Platelet Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
- Pregnancy and Medication Impact
- Renal and related cancers
- Childhood Cancer Survivors' Quality of Life
- Celiac Disease Research and Management
- Pharmaceutical studies and practices
- Biomedical Research and Pathophysiology
- Organ Transplantation Techniques and Outcomes
- Chronic Lymphocytic Leukemia Research
- Muscle and Compartmental Disorders
University of Florida
2011-2022
University of South Florida
1993-2006
Florida College
1978-2002
Yale University
2001
University of South Florida St. Petersburg
2001
Kosair Children's Hospital
2001
University of Louisville
2001
Duke University
1996
Hôpital Pontchaillou
1994
Tampa General Hospital
1993
OBJECTIVES. To evaluate the role of primary vesicoureteral reflux (VUR) in increasing frequency and severity urinary tract infections (UTIs) renal parenchymal damage among patients with acute pyelonephritis to determine whether antibiotic prophylaxis reduces and/or UTIs prevents mild/moderate VUR. METHODS. Patients 3 months 18 years age pyelonephritis, or without VUR, were assigned randomly receive not. monitored every for 1 year. Dimercaptosuccinic acid scans repeated at 6 if there was a...
CD80 is expressed on all antigen-presenting cells and present podocytes in a number of experimental models nephrotic syndrome. We tested whether urinary soluble increased with idiopathic minimal-change disease (MCD). collected urine serum samples from patients MCD relapse remission, syndrome resulting other glomerular diseases (FSGS, membranoproliferative glomerulonephritis, IgA nephropathy, membranous nephropathy), systemic lupus erythematosus, normal control subjects. Urinary...
Background.Recent studies suggest that CD80 (also known as B7.1) is expressed on podocytes in minimal-change disease (MCD) and may have a role mediating proteinuria. expression to be induced by Toll-like receptor (TLR) ligands dendritic cells. We therefore evaluated the ability of TLR induce human cultured podocytes.
BackgroundWe have reported that children with biopsy-proven minimal change disease (MCD) express CD80 (also known as B7.1) in their podocytes and excrete high levels of urine during active nephrotic syndrome. We also polyIC, a Toll-like receptor 3 ligand, increases mRNA protein expression cultured human dose-dependently, actin re-organization reduction synaptopodin expression.
This study was designed to assess sequentially the nutrient intake in children with chronic renal insufficiency and its relationship body size, level of failure, growth velocity.The from 401 4-day food records obtained 120 over a 6-month observation period analyzed. The height weight were measured at beginning end period. glomerular filtration rate estimated serum creatinine.The mean caloric these 80 +/− 23% (mean SD) Recommended Dietary Allowance (RDA) for age. Fifty-six percent revealed...
We have conducted a controlled trial on the efficacy of cyclosporine in eight patients with steroid-resistant nephrotic syndrome (four idiopathic minimal lesion and four focal segmental glomerulosclerosis). Patients were randomly allocated to (5 mg/kg/d) or control group. After weeks therapy one month without therapy, group given for those became controls. Before initiation treatment, there was no difference between groups regard proteinuria serum albumin levels. Proteinuria remained...
Abstract Background Primary FSGS manifests with nephrotic syndrome and may recur following KT. Failure to respond conventional therapy after recurrence results in poor outcomes. Evaluation of podocyte B7-1 expression treatment abatacept (a antagonist) has shown promise but remains controversial. Methods From 2012 2020, twelve patients developed post-KT range proteinuria, failed therapy, were treated abatacept. Nine/twelve (< 21 years old) experienced recurrent FSGS; three adults de novo...
Araya CE, Garin EH, Neiberger RE, Dharnidharka VR. Leflunomide therapy for BK virus allograft nephropathy in pediatric and young adult kidney transplant recipients.Pediatr Transplantation 2010: 14: 145–150. © 2009 Wiley Periodicals, Inc. Abstract: BKVAN affects about 5% of recipients may lead to graft failure. Treatment is challenging. Leflunomide, an immunosuppressant with antiviral activity vitro was used successfully some patients but there are no reports its use patients. We present our...