A5031683109- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renin-Angiotensin System Studies
- Mitochondrial Function and Pathology
- Hormonal Regulation and Hypertension
- Chronic Kidney Disease and Diabetes
- Hepatitis C virus research
- Metabolism and Genetic Disorders
- Dialysis and Renal Disease Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Hypoxia, and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Systemic Lupus Erythematosus Research
- Acute Kidney Injury Research
- Apelin-related biomedical research
- Nail Diseases and Treatments
- Dermatological and Skeletal Disorders
- Contact Dermatitis and Allergies
- Parathyroid Disorders and Treatments
- Blood donation and transfusion practices
- Alcoholism and Thiamine Deficiency
- Vasculitis and related conditions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Bone health and osteoporosis research
- Vitamin K Research Studies
Hirosaki University
2013-2020
Daiichi Sankyo (Germany)
2016
Daiichi-Sankyo (South Korea)
2016
E Ink (South Korea)
2016
Hirosaki University Hospital
2014
Background An enhanced renin-angiotensin system causes hypertensive renal damage. Factor Xa not only functions in the coagulation cascade but also activates intracellular signaling through protease-activated receptors ( PAR ). We investigated effects of rivaroxaban, a factor inhibitor, on damage mice overexpressing renin (Ren-TG). Methods and Results The 12- to 16-week-old Ren-TG wild-type were orally administered with or without 6 12 mg/kg rivaroxaban for 1 4 months. Plasma was...
Enhanced renin-angiotensin activity causes hypertension and cardiac hypertrophy. The angiotensin (Ang)-converting enzyme (ACE)2/Ang(1-7)/Mas axis pathway functions against Ang II type 1 receptor (AT1R) signaling. We investigated whether olmesartan (Olm), an AT1R blocker, inhibits hypertrophy independently of blood pressure, evaluated the potential mechanisms. 3- to 4-month-old male mice overexpressing renin in liver (Ren-Tg) were given Olm (5 mg/kg/d) hydralazine (Hyd) (3.5 orally for 2...
Myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) and concurrent membranous nephropathy (MN) are very rare combination. Their causal relationship has been suggested, but not determined. A 73-years-old male with 5-year history of proteinuria underwent an operation for his sigmoid colon cancer. Seven months later, he was referred to a nephrology division due exacerbating renal function hypoalbuminemia. Laboratory examination revealed positive...
None declared. Table S1. Background of donors. S2. Baseline characteristics between non-marginal and marginal Please note: The publisher is not responsible for the content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.
Enhanced renin-angiotensin activity contributes to hypertension, albuminuria, and glomerular hypertrophy. The angiotensin (Ang)-converting enzyme (ACE) 2/Ang (1-7)/Mas axis pathway acts against Ang II type 1 receptor (AT1R) signaling. We investigated whether olmesartan (Olm), an AT1R blocker, inhibits albuminuria independently of blood pressure elucidated the potential mechanisms.Three- 4-month-old male mice overexpressing renin in liver (Ren-TG) were given (5 mg/kg/day) or hydralazine (Hyd)...
Background We previously showed that phospholipase C (PLC)-δ1 activity was enhanced by 3-fold in patients with coronary spastic angina (CSA). also reported p122Rho GTPase-activating protein/deleted liver cancer-1 (p122RhoGAP/DLC-1) protein, which discovered as a PLC-δ1 stimulator, upregulated CSA patients. tested the hypothesis p122RhoGAP/DLC-1 overexpression causes spasm. Methods and Results generated transgenic (TG) mice vascular smooth muscle (VSM)-specific of p122RhoGAP/DLC-1. The gene...
The aim of this study was to clarify the rates remission and progression for microalbuminuria in patients with type 2 diabetes (T2DM); factors associated diabetic nephropathy (DN).T2DM a urinary albumin excretion (UAE) rate 30-300 mg/gCr who were attending medical clinic Tsugaru region Japan enrolled into prospective, observational 36 months (N=317). We investigated (UAE <30 mg/g creatinine (Cr); normal albuminuria) ≥300 mg/gCr; overt proteinuria) after registration.The number whose UAE...
Osteoprotegerin is a natural glycoprotein which plays critical role in osteoclast physiology. Elevated levels of circulating osteoprotegerin may account for the development bone and mineral metabolic abnormalities uremia. Little known about effects vitamin D therapy on dialysis patients.Fifty chronic patients whose plasma intact PTH were greater than 300 pg/ml analyzed study. Following four-week washout time during all administration was halted, 10 microg maxacalcitol intravenously injected...
A simple method involving immunoaffinity column chromatography to purify the thermostable direct hemolysin of Vibrio parahaemolyticus was developed. The purified from culture supernatant a strain isolated first reported case V. infection in China 1985 indistinguishable hemolysins strains Japan.
Pulmonary artery thrombosis is one of the most important complications in patients with nephrotic syndrome. It well known among nephrologists, however, that this possibly lethal complication very rarely occurs before diagnosis syndrome.A 21-year-old Japanese woman who had no specific medical history consulted a primary care clinic. Although she been aware edema her lower extremities for 2 weeks, chief complaints were palpitations and chest pain, which started day before. An electrocardiogram...
Background. Ethylene glycol intoxication causes severe metabolic acidosis and acute kidney injury. Fomepizole has become available as its antidote. Nevertheless, a prompt diagnosis is not easy because patients are often unconscious. Here we present case of ethylene who successfully recovered with hemodialysis. Case Presentation. A 52-year-old Japanese male was admitted to local hospital due suspected food poisoning. The patient presented nausea vomiting, but his condition rapidly...
Pneumoperitoneum, the presence of free air within peritoneal cavity, is often caused by perforation gas-containing viscus and commonly requires surgical treatment. However, in patients with dialysis, seen on X-ray. We present case a patient dialysis marked pneumoperitoneum. A 75-year-old Japanese male end-stage renal disease due to antineutrophil cytoplasmic antigen-associated vasculitis had been receiving continuous ambulatory for 9 years. He poor appetite general malaise without abdominal...
It is sometimes challenging to diagnose unsusual cases of fibrillary glomerulonephritis (FGN) and immunotactoid glomerulopathy (ITG), the rare causes nephrotic syndrome. A 75-year-old Japanese woman presented with syndrome, microhematuria renal insufficiency. Renal biopsy revealed membranoproliferative (MPGN) IgM weak C3 deposition. Congo red stain was negative. Electron microscopy demonstrated massive fibrils in subendothelium, mesangium subepithelium. The were partially parallel, curved 17...
Background: We recently showed that ergometrine induces coronary spasm in the mice with enhanced phospholipase C (PLC)-δ1 activity, which was detected patients (Circulation 2012), and PLC-mediated Ca2+ entry is involved genesis of spams. examined role PLC-δ1 extracellular its underlying mechanisms human embryonic kidney (HEK)-293 cells arteries smooth muscle (CASMC). Methods Results: The were stimulated acetylcholine (ACh) a Ca2+-free condition, increase intracellular free concentration...
Objective: Long-acting darbepoetin-α (DA) has recently been used to treat renal anemia in patients with chronic failure. It is considered clinically useful because its duration of action longer than that conventional epoetin-α. In this study, we investigated changes the levels oxidative stress marker malondialdehyde-modified low density lipoprotein (MDA-LDL), anemia, and function when were treated for failure switched from epoetin-α DA. Materials Methods: The subjects included nine who on an...
In the chronic kidney disease (CKD), adequate phosphate control is critical to reduce mortality rate and cardiovascular risks, besides, it may improve renal prognosis. We surveyed awareness of high content in commercially processed food drinks among transplant recipients, since they usually have reduced function. Thirty seven subjects were provided with a questionnaire evaluate their containing phosphate. Most (91.9%) aware presence sugar soda drinks, but only 13.5% Only 29.7% understood...
Backgrounds: We reported that the activity of phospholipase C (PLC)-δ1, a key enzyme for Ca2+ signaling in artery, was 3-fold enhanced patients with coronary spastic angina (CSA), and positively correlated vasomotility. recently showed p122RhoGAP/DLC1 (DLC1) protein, which discovered as stimulator PLCδ-1, upregulated CSA patients. tested hypothesis overexpression DLC1 cause spasm mice. Methods Results: generated transgenic (TG) C57BL/6J mice vascular smooth muscle-specific DLC1. The gene...