A5051323408- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Pharmacogenetics and Drug Metabolism
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Cardiomyopathy and Myosin Studies
- Neurological disorders and treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Ion channel regulation and function
- Protein Kinase Regulation and GTPase Signaling
- Congenital Heart Disease Studies
- Viral Infections and Immunology Research
- Cardiac Imaging and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Steroid Chemistry and Biochemistry
- Chronic Kidney Disease and Diabetes
- Acute Myocardial Infarction Research
- Renin-Angiotensin System Studies
- Angiogenesis and VEGF in Cancer
- ATP Synthase and ATPases Research
- Healthcare Technology and Patient Monitoring
Hirosaki University
2015-2025
Hirosaki University Hospital
2022
E Ink (South Korea)
2016
Daiichi Sankyo (Germany)
2016
Daiichi-Sankyo (South Korea)
2016
Although contact force (CF)-guided circumferential pulmonary vein isolation (CPVI) for paroxysmal atrial fibrillation (PAF) is useful, AF recurrence at long-term follow-up still remains to be resolved. The purpose of this study was assess safety and efficacy CF-guided CPVI compare residual conduction gaps during outcome between the conventional (non-CF-guided) CPVI.We studied 50 consecutive PAF patients undergoing by a ThermoCool EZ Steer catheter (conventional group, mean age 61 ± 10 years)...
Abstract Rivaroxaban is excreted from the body via multiple pathways involving glomerular filtration, drug‐metabolizing enzymes and transporters. In this study, we aimed to examine impact of single nucleotide polymorphisms in P‐glycoprotein, breast cancer resistance protein, cytochrome P450 (CYP) 3A5 CYP2J2 on pharmacokinetics rivaroxaban. Eighty‐six patients with non‐valvular atrial fibrillation (NVAF) undergoing AF catheter ablation were enrolled study. these analyses, dose‐adjusted plasma...
Enhanced renin-angiotensin activity causes hypertension and cardiac hypertrophy. The angiotensin (Ang)-converting enzyme (ACE)2/Ang(1-7)/Mas axis pathway functions against Ang II type 1 receptor (AT1R) signaling. We investigated whether olmesartan (Olm), an AT1R blocker, inhibits hypertrophy independently of blood pressure, evaluated the potential mechanisms. 3- to 4-month-old male mice overexpressing renin in liver (Ren-Tg) were given Olm (5 mg/kg/d) hydralazine (Hyd) (3.5 orally for 2...
Background:Direct oral anticoagulants (DOACs) are effective in reducing thromboembolism events patients with non-valvular atrial fibrillation (NVAF). However, little is known about trends NVAF prevalence and DOAC prescriptions daily clinical practice. This study investigated the current status a region of Japan.
CartoSound™ (CS) module is useful in integrating 3-dimensional (3D) left atrial (LA) image with CT image. Integration method, however, has not been established. We reported the accuracy of LA electroanatomical (EA) and integration by registering roof (LAR) posterior wall (LAPW).The consecutive 56 fibrillation patients undergoing pulmonary vein isolation were studied. In initial 29 patients, before transseptal puncture, 3D CS LAR LAPW was created a mean 10 contour lines between right veins....
Low conduction velocity (CV) in the area showing low electrogram amplitude (EA) is characteristic of reentry circuit atypical atrial flutter (AFL). The quantitative relationship between CV and EA remains unclear. We characterized AFL right atrium (RA), focusing on local bipolar circuit.We investigated 26 RA (10 with typical AFL; 10 incisional 6 nonincisional AFL) using CARTO system. By referring to isochronal propagation maps delineated during AFL, points activated faster were selected...
The characteristics and clinical outcomes associated with sustained ventricular tachycardia fibrillation (VT/VF) in Japanese acute myocardial infarction (AMI) patients remain unknown.
By using a noncontact mapping system, adenosine triphosphate (ATP)-sensitive atrial tachycardia (ATP-AT) originating from the atrioventricular (AV) node vicinity was successfully ablated at entrance to slow conduction zone indicated by manifest entrainment technique. We aimed prospectively validate efficacy of combination CARTO electroanatomical and in ablating this ATP-AT. Of 27 AT patients January 2013 March 2014, 6 with sustained ATP-AT were studied (age, 67±13 years; cycle length, 350±95...
Postpacing interval (PPI) measured after entrainment pacing describes the distance between site and reentrant circuit. However, influential features to PPI remain be elucidated.This study included 22 cases with slow/fast atrioventricular (AV) nodal tachycardia (AVNRT), 14 orthodromic AV reciprocating (AVRT) using an accessary pathway, typical atrial flutter (AFL), 18 other macroreentrant (atypical AFL). Rapid at a cycle length (PCL) 5% shorter than (TCL) was done from on or close reentry...
During ventricular pacing, a fusion of atrial activation may occur owing to the simultaneous retrograde conduction atrioventricular (AV) node and accessory pathway (AP), potentially leading an inaccurate mapping AP insertion site.We tested hypothesis that landiolol, ultra-short-acting intravenous β1-blocker, could dissociate activation.We conducted prospective before-and-after study investigate effect landiolol on via AV AP. We enrolled 21 consecutive patients with orthodromic reciprocating...
A patient with hypertrophic cardiomyopathy experienced cardiopulmonary arrest. An automated external defibrillator administered defibrillation for ventricular fibrillation (A). The pacemaker recorded atrial tachycardia a rapid response before the collapsed (B). After few minutes, records dual tachyarrhythmia, characterized by simultaneous presence of (VF) and (AF) (C). This case demonstrates that VF induced tachyarrhythmia could contribute to AF-related sudden cardiac death.
Background We previously showed that phospholipase C (PLC)-δ1 activity was enhanced by 3-fold in patients with coronary spastic angina (CSA). also reported p122Rho GTPase-activating protein/deleted liver cancer-1 (p122RhoGAP/DLC-1) protein, which discovered as a PLC-δ1 stimulator, upregulated CSA patients. tested the hypothesis p122RhoGAP/DLC-1 overexpression causes spasm. Methods and Results generated transgenic (TG) mice vascular smooth muscle (VSM)-specific of p122RhoGAP/DLC-1. The gene...
Background:The entirely subcutaneous implantable cardioverter defibrillator (S-ICD) was introduced as a new alternative to conventional transvenous ICD (TV-ICD) in Japan February 2016, but its safety and efficacy are unclear.
Calcium antagonists are used for coronary spastic angina (CSA) treatment. We previously identified a phospholipase C (PLC) -δ1 gene variant that results in enhanced PLC activity patients with CSA and developed animal model by generating vascular smooth muscle cell-specific human PLC-δ1 overexpression (PLC-TG) mice. In this study, we investigated the molecular mechanism of using PLC-TG mice inhibitory effect calcium antagonist, diltiazem hydrochloride (DL).
Abstract Background The Medtronic implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy with (CRT‐D) device is equipped the OptiVol fluid status monitoring system, which continuously measures intrathoracic impedance provides an early warning of thoracic retention, indicative decompensated heart failure (HF). accuracy telediagnosis HF this system still remains to be elucidated. Methods We studied 82 chronic patients implanted a ICD/CRT‐D (mean age 66±12 years, 62...