A5103017326- Bladder and Urothelial Cancer Treatments
- Adrenal and Paraganglionic Tumors
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Rheumatoid Arthritis Research and Therapies
- Sperm and Testicular Function
- Lymphoma Diagnosis and Treatment
- Urologic and reproductive health conditions
- Multiple and Secondary Primary Cancers
- Cancer, Hypoxia, and Metabolism
- Testicular diseases and treatments
- Sexual Differentiation and Disorders
- Hernia repair and management
- Shoulder Injury and Treatment
- Muscle Physiology and Disorders
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Drug-Induced Adverse Reactions
- Metabolism, Diabetes, and Cancer
- Reproductive Biology and Fertility
- Metastasis and carcinoma case studies
Kyoto Medical Center
2011-2024
University of California, San Diego
2015-2024
Tohoku Rosai Hospital
2017-2023
Tohoku University Hospital
2013-2020
Tohoku University
2004-2020
Osaka Gakuin University
2018
Christie's
2016
Ministry of Health Labour and Welfare
2016
Japanese Red Cross Society, Japan
2016
University Medical Center
2016
Nocturia has a major impact on quality of life and affects numerous aspects health. Lifestyle modifications are expected to be helpful in improving nocturia. However, the efficacy this strategy not been established. We tested nondrug lifestyle measures as first step treating nocturia found factors predictive intervention.We conducted prospective evaluation 56 patients treated at 3 hospitals between 2005 2009 for symptomatic The were advised modify their improve consisted 4 directives 1)...
The active form of vitamin D (1,25-dihydroxy-vitamin D3) is known to increase fast-type myosin heavy chain expression in differentiated myogenic cell lines. mechanisms for this effect are not fully understood. aim study was determine the role signals transmitted through receptor (VDR) during differentiation myoblasts.Electroporation used introduce VDR siRNA molecules into C2C12 and G8 murine myoblast Gene protein profiles VDR-gene silenced cells were analyzed vitro.Suppressing by RNA...
Objectives: The purpose of this study was to facilitate the understanding SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis) syndrome by analyzing clinical radiological features 67 Japanese patients with syndrome. Methods: Sixty-seven (female/male: 44/23, mean age at onset: 48.5 years) were diagnosed from 2002 2013 our hospital. Medical records imaging these retrospectively reviewed. Results: Among patients, 41 had dermatological manifestations, such as palmoplantar pustulosis,...
We investigated the effect of VD3 (1α,25-dihydroxyvitamin D3) on proliferating, differentiating and differentiated phases C2C12 myoblasts, a mouse skeletal muscle cell line. treatment in 10% FBS (fetal bovine serum) inhibited proliferation viability cells dose-dependent manner. It also dose-dependently increased percentage G0/G1 phase as shown by flow cytometry. In phase, formation myotubes expression total myosin heavy chain at both mRNA protein levels. had no significant amount chain,...
Abstract Background Avelumab + axitinib was approved for advanced renal cell carcinoma (aRCC) in Japan December 2019. We report long-term real-world outcomes with first-line avelumab from the J-DART2 study Japan. Methods a multicenter, noninterventional, retrospective examining clinical data patients curatively unresectable locally or metastatic RCC who started treatment between 2019 and October 2022. Endpoints included patient characteristics, patterns, outcomes. Results Data 150 across 19...
Four knees in three patients with traumatic separation of a Type I bipartite patella are reported. Sudden anterior knee pain and an audible pop occurred at the time injury had aching or dull before episode. Previous led us to differentiate this type from usual transverse fracture. A round fracture line seen on radiographs also stress Accordingly, diagnosis was confirmed. This is first report our knowledge.
Objectives To determine prognostic factors of clinically relevant radiographic progression (CRRP) in patients with rheumatoid arthritis (RA) achieving remission or low disease activity (LDA) clinical practice. Methods Using data from a nationwide, multicenter, prospective study Japan, we evaluated 198 biological disease-modifying antirheumatic drug (bDMARD)-naïve RA who were had LDA at entry after being treated conventional synthetic DMARDs (csDMARDs). CRRP was defined as the yearly modified...
Abstract Objective To develop and validate a preoperative nomogram to predict pathological locally advanced disease (pLAD) of clinically localized upper urinary tract urothelial carcinoma (UTUC) treated with extirpative surgery. Methods In total, 1101 patients cN0M0 UTUC (development cohort, n = 604; validation 497) from 2 independent academic databases were retrospectively analyzed. pLAD was defined as pT3/4 and/or pN+. Multivariate logistic regression used nomogram. The accuracy the...
Abstract Purpose: Although cell-free DNA (cfDNA) testing is expected to drive cancer precision medicine, little known about the significance of detecting low-frequency variants in circulating tumor (ctDNA) castration-resistant prostate (CRPC). We aimed identify genomic profile including ctDNA from patients with CRPC and investigate clinical utility variant allele frequency (VAF) below 1%. Experimental Design: This prospective, multicenter cohort study enrolled eligible for treatment...
Abstract This study aimed to assess the effects of thienopyridine-class antiplatelet agents (including ticlopidine, clopidogrel, and prasugrel) on bleeding complications in patients who underwent robot-assisted radical prostatectomy. cohort used a database for prostatectomy at 23 tertiary centers nationwide between 2011 2022. Patients received thienopyridines (thienopyridine group) were compared with those aspirin monotherapy (aspirin group). The primary outcome was incidence complications....
The acetyltransferase, E1a-binding protein (p300), is proposed to regulate various aspects of skeletal muscle development, metabolism, and mitochondrial function,viaits interaction with numerous transcriptional regulators other proteins. Remarkably, however, the contribution p300 function metabolism,in vivo, poorly understood. To address this, we used Cre-LoxP methodology generate mice muscle-specific knockout (mKO). mKO were indistinguishable from their wild-type/floxed littermates, no...
The aim of the present study was to assess usability and efficacy our new protocol prophylactic antibiotic use prevent perioperative infection in urological surgery.We prospectively investigated 339 cases typical surgery department between April 2001 March 2002 (group I). We classified surgical procedures into four categories by invasiveness contamination levels: category A, clean less invasive or endoscopic surgery; B, contaminated C, urinary tract diversion using intestine; D, infected...
To determine prognostic factors of clinically relevant radiographic progression (CRRP) in patients with rheumatoid arthritis (RA) clinical practice. We performed a multicenter prospective study Japan biological disease-modifying antirheumatic drug (bDMARD)-naive RA moderate to high disease activity treated conventional synthetic DMARDs (csDMARDs) at entry. longitudinally observed 408 for 1 year and assessed every 3 months. CRRP was defined as yearly modified total Sharp score (mTSS) > 3.0 U....
It has been reported that Bach1-deficient mice show reduced tissue injuries in diverse disease models due to increased expression of heme oxygenase-1 (HO-1)that possesses an antioxidant function. In contrast, we found Bach1 deficiency exacerbated skeletal muscle injury induced by cardiotoxin. Inhibition C2C12 myoblast cells using RNA interference resulted proliferation, myotube formation, and myogenin compared with control cells. While the HO-1 was silencing cells, formation not rescued...
Nobiletin and tangeretin (NoT) are flavonoids derived from the peel of Citrus depressa, they have been found to modulate circadian rhythms. Because nocturia can be considered a rhythm disorder, we investigated efficacy NoT for treating nocturia. A randomized, placebo-controlled, double-blind, crossover study was conducted. The trial registered with Japan Registry Clinical Trials (jRCTs051180071). Nocturia patients aged ≥50 years who presented more than 2 times on frequency–volume chart were...
This study aimed to analyse the radiological characteristics and clinical diversity of Japanese patients with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome, a heterogeneous disorder.
Objective To report the outcomes of repeat biopsies, metastasis and survival in Prostate Cancer Research International: Active Surveillance (PRIAS)‐JAPAN study, a prospective observational study for Japanese patients, initiated 2010. Patients Methods At beginning, inclusion criteria were initially low‐risk prostate‐specific antigen (PSA) density (PSAD) <0.2, ≤2 positive biopsy cores. As from 2014, GS3+4 has also been allowed patients aged 70 years over. Since January 2021, age limit...
Background. Previously, we developed a new organ preserving solution, ET-Kyoto solution (ETKS), and showed that it is effective for lung skin cold storage. Our high sodium–low potassium containing trehalose gluconate chemically stable at room temperature. In this study, the efficacy of ETKS renal storage compared with Euro-Collins (ECS) University Wisconsin (UWS) was investigated. Methods. A preflush Krebs-Henseleit buffer used before because ECS UWS, but not ETKS, failed to be distributed...