A5035859888- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Disorders and Syndromes
- Musculoskeletal synovial abnormalities and treatments
- Chronic Lymphocytic Leukemia Research
- Viral Infections and Immunology Research
- Renal Diseases and Glomerulopathies
- Salivary Gland Disorders and Functions
- Bone and Joint Diseases
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Immunodeficiency and Autoimmune Disorders
- Spondyloarthritis Studies and Treatments
- IgG4-Related and Inflammatory Diseases
- Peripheral Neuropathies and Disorders
- Nutrition and Health in Aging
- Lymphoma Diagnosis and Treatment
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Sarcoidosis and Beryllium Toxicity Research
- T-cell and B-cell Immunology
Nagasaki University
2016-2025
Nagasaki University Hospital
2009-2024
Center for Rheumatology
2015-2020
Creative Commons
2016-2018
Yale University
2018
American College of Rheumatology
2018
Nagasaki Medical Center
2016-2017
Sasebo City General Hospital
2013-2016
Kurume University
1997-2016
Christie's
2016
Objective. Interstitial lung disease (ILD), especially rapidly progressive ILD (RPILD), is a major poor prognostic factor in patients with DM. We investigated the association of anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab) clinical characteristics and mortality Japanese
We investigated the relationships among M1 monocytes, M2 osteoclast (OC) differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (RA).Peripheral blood mononuclear cells (PBMCs) were isolated from RA healthy donors, we then number of monocytes or by fluorescence-activated cell sorting. also obtained cultured CD14-positive PBMCs donors to investigate OC vitro.Forty 20 included. Twenty-two (55%) anticitrullinated protein antibody (ACPA) positive. The median...
<h3>Abstract</h3> <h3>Background</h3> The COVID-19 pandemic has caused interruptions to chronic disease and non-emergency treatment. purpose of this study is examine which socioeconomic status groups are most at risk treatment interruption. <h3>Methods</h3> This cross-sectional internet monitor was conducted on December 22–26, 2020, when Japan experienced its third wave infection. Out a total 33,302 participants in the survey, 9510 (5392 males 4118 females) who responded that they required...
To evaluate whether magnetic resonance imaging (MRI) of the wrists and finger joints an analysis serologic autoantibodies are clinically meaningful for subsequent development rheumatoid arthritis (RA) in patients with undifferentiated (UA).A total 129 UA, a disease status formally confirmed by rheumatologist over period at least 1 year, were included. Gadolinium-diethylenetriamine-enhanced MRI both variables examined upon admission to our Early Arthritis Clinic Nagasaki University. After...
To investigate whether the frequency of peripheral blood (PB) regulatory T cells (Treg) correlates with clinical disease activity rheumatoid arthritis (RA).PB Treg cells, defined as CD4+CD25(high)CD127(low/-) population, were examined by flow cytometry in 48 patients RA, including 13 who had never received disease-modifying antirheumatic drugs (DMARD), 19 active receiving (n = 14) or 5) DMARD, and 16 DMARD whose was remission. The 28-joint Disease Activity Score (DAS28). association DAS28,...
Objective. We have tried to clarify the clinical importance of measurement serum type-I interferon (IFN) in patients with anti-melanoma differentiation-associated gene 5 Ab (MDA5 Ab)-positive dermatomyositis (DM). Methods. studied 30 DM: 10 were anti-MDA5 Ab-positive and 20 Ab-negative. At each patient's initial visit, IFN-α, IFN-β, interleukin 18 (IL-18), ferritin, titer measured using enzyme-linked immunosorbent assays (ELISAs). The associations between IFNs other variables examined....
To clarify the significance of immunometabolism in systemic lupus erythematosus (SLE), and to determine effect calcium/calmodulin-dependent protein kinase 4 (CaMK4) on T cell metabolism.Metabolomic profiling was performed using capillary electrophoresis mass spectrometry naive cells from MRL/lpr mice treated with anti-CD3/CD28 antibodies absence or presence a CaMK4 inhibitor (KN-93). The expression GLUT1 CD4+ healthy controls (n = 16), patients inactive SLE 13), active 14) examined by flow...
The precise cytokine networks in the serum of individuals with familial Mediterranean fever (FMF) that are associated its pathogenesis have been unknown. Here, we attempted to identify specific biomarkers diagnose or assess disease activity FMF patients. We measured levels 45 cytokines 75 patients and 40 age-matched controls by multisuspension array. "attack" "remission" was classified Japan College Rheumatology-certified rheumatologists according Tel Hashomer criteria. Cytokines were ranked...
The autoimmune response in rheumatoid arthritis (RA) is marked by the presence of anti-citrullinated protein antibodies (ACPAs). A notable feature IgG ACPA abundant expression N-linked glycans variable domain. However, domain glycosylation (VDG) across disease stages, and its to therapy, are poorly described. To understand dynamics, we investigated abundance VDG 1,498 samples from individuals different clinical stages.Using liquid chromatography, analyzed profiles 7 cohorts Japan, Canada,...
Objective: To determine the association of distinct clinical subsets with myositis‐specific autoantibodies (MSAs) towards anti‐155/140‐kDa polypeptides [anti‐155/140 antibodies (Abs)], anti‐140‐kDa (anti‐140 Abs), and anti‐aminoacyl tRNA synthetases (ARS Abs) in Japanese patients dermatomyositis (DM).Methods: We compared features short‐term prognoses 30 DM whose serological status included these MSAs. The MSAs were determined by immunoprecipitation.Results: Anti‐155/140 Abs (n = 5), anti‐140...
Objective. We evaluated the significance of power Doppler ultrasonography (PDUS) score by comparing it with serum biomarkers and clinical disease activity.
Analysis of circulating immune complexes (CICs) produced during an response may be useful in elucidating some aspects this process. Identification antigens incorporated into CICs provides information that helpful developing diagnostic and treatment strategies for autoimmune diseases, infection, cancer, transplantation therapy, such might more relevant than on free antigens. Because contain many antigens, comprehensive identification profiling is effective immunoblotting detection.We...
Objective. The aim of this study was to investigate the characteristics power Doppler (PD) subclinical synovitis in patients with RA who achieve clinical remission free from physical synovitis.
Kidney podocytes and their slit diaphragms prevent urinary protein loss. T cells from patients with systemic lupus erythematosus display increased expression of calcium/calmodulin-dependent kinase IV (CaMKIV). The present study was undertaken to investigate the role CaMKIV in podocyte function nephritis (LN).We treated kidney IgG derived healthy individuals or LN then analyzed gene using a DNA microarray. localization by immunofluorescence staining, without silencing neonatal Fc receptor...
Polymyositis/dermatomyositis (PM/DM) is an autoimmune disease that sometimes complicated with rapidly progressive interstitial lung (RPILD). However, serum and biomarkers can predict RPILD development remain unclear.To determine potential in patients PM/DM-ILD.In total, 49 PM/DM-ILD were enrolled. We measured the levels of 41 cytokines/chemokines, ferritin anti-MDA5 antibody, compared them between (n = 23) non-RPILD 26) groups, ranked by their importance through random forest analysis. To...
To compare the efficacy and safety of tofacitinib baricitinib in patients with RA a real-world setting. A total 242 who were treated (n = 161) or 81) enrolled. We evaluated between using multivariable analyses to avoid confounding. Their clinical disease activity AEs for 24 weeks. The mean (SD) DAS28-ESR change from baseline weeks was 1.57 (1.55) (tofacitinib) 1.46 (1.36) (baricitinib). There no significant difference response two groups (adjusted difference, 0.04; 95% CI, -0.35 0.28). not...
We have experienced a Takayasu arteritis (TA) patient, successfully treated with infliximab, who did not respond well to conventional therapy glucocosteroid and methotrexate. had developed in 24yearold woman (March 2003) been glucocorticoid including methylprednisolone pulse methotrexate; however, she relapsed during the tapering of dosage oral prednisolone. Nineteen months after first administration glucocorticoid, 3 mg/kg infliximab was introduced patient. The therapeutic efficacy markedly...
SUMMARY We examined the role of osteoprotegerin (OPG) on tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in rheumatoid fibroblast-like synovial cells (FLS). OPG protein concentrations fluid from patients with arthritis (RA) correlated those interleukin (IL)-1β or IL-6. A similar correlation was present between IL-1β and IL-6 concentrations. Rheumatoid FLS vitro expressed both death domain-containing receptors [death receptor 4 (DR4) DR5] decoy [decoy 1...
To elucidate the characterization of peripheral natural killer (NK) cells in patients with rheumatoid arthritis (RA), we investigated NK cell activity, expression activating receptors and intracellular molecules. The activity was analyzed 27 RA patients, 22 primary Sjögren's syndrome (SS) 15 healthy individuals using (51)Chrominium release assay. (NKG2D, CD244, CD2, CD16) molecules (granzyme B, perforin, TCR zeta chain) CD3-CD56+ were characterized by flow cytometry. serum cytokine levels...
We investigated whether musculoskeletal ultrasonography (MSKUS) assists the diagnostic performance of 2010 rheumatoid arthritis (RA) classification criteria.Sixty-nine early patients were consecutively enrolled. None had been treated. In MSKUS bilateral wrist and finger joints from 22 sites, findings obtained by gray-scale power Doppler (PD) assessment graded on a semiquantitative scale 0 to 3. Plain magnetic resonance imaging (MRI) both was also examined. Diagnosis RA defined initiation...