A5109375276- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders Research
- IgG4-Related and Inflammatory Diseases
- Eosinophilic Disorders and Syndromes
- Neuroendocrine Tumor Research Advances
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Musculoskeletal synovial abnormalities and treatments
- Viral Infections and Immunology Research
- Renal Diseases and Glomerulopathies
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Inflammatory Myopathies and Dermatomyositis
- Salivary Gland Disorders and Functions
- T-cell and B-cell Immunology
- Sarcoidosis and Beryllium Toxicity Research
- Atherosclerosis and Cardiovascular Diseases
- Exercise and Physiological Responses
- Lymphoma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bone and Joint Diseases
Nagasaki University
2016-2025
Center for Rheumatology
2018
Creative Commons
2016-2018
Nagasaki Medical Center
2016-2017
Sasebo City General Hospital
2013-2016
Kurume University
2011-2016
Ministry of Health Labour and Welfare
2009-2016
Nagasaki University Hospital
2001-2016
Japanese Red Cross Society, Japan
2009-2016
Christie's
2016
<h3>Background:</h3> Mikulicz's disease (MD) has been considered as one manifestation of Sjögren's syndrome (SS). Recently, it also an IgG<sub>4</sub>-related disorder. <h3>Objective:</h3> To determine the differences between disorders including MD and SS. <h3>Methods:</h3> A study was undertaken to investigate patients with registered in Japan set up provisional criteria for new clinical entity IgG<sub>4</sub>-positive multiorgan lymphoproliferative (IgG<sub>4</sub>+MOLPS). The preliminary...
Objective. Interstitial lung disease (ILD), especially rapidly progressive ILD (RPILD), is a major poor prognostic factor in patients with DM. We investigated the association of anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab) clinical characteristics and mortality Japanese
We investigated the relationships among M1 monocytes, M2 osteoclast (OC) differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (RA).Peripheral blood mononuclear cells (PBMCs) were isolated from RA healthy donors, we then number of monocytes or by fluorescence-activated cell sorting. also obtained cultured CD14-positive PBMCs donors to investigate OC vitro.Forty 20 included. Twenty-two (55%) anticitrullinated protein antibody (ACPA) positive. The median...
IgG4-related disease is a new classification established in Japan the 21st century. Patients with display hyper-IgG4-gammaglobulinemia, massive infiltration of IgG4+ plasma cells into tissue, and good response to glucocorticoids. Since IgG4 overexpression also observed other disorders, it necessary diagnose carefully correctly. We therefore sought determine cutoff values for serum IgG4/IgG IgG4+/IgG+ tissue diagnostic disease. Methods . retrospectively analyzed concentrations ratio cell...
Objective Takayasu arteritis (TAK) is a systemic vasculitis affecting large arteries and branches of the aorta. Ulcerative colitis (UC) prevalent autoimmune colitis. Since TAK UC share HLA–B*52:01 IL12B as genetic determinants, since there are case reports co‐occurrence these diseases, we hypothesized that common complication TAK. We undertook this study to perform large‐scale analysis TAK, both evaluate prevalence concurrent cases identify estimate susceptibility genes shared between 2...
<h3>Abstract</h3> <h3>Background</h3> The COVID-19 pandemic has caused interruptions to chronic disease and non-emergency treatment. purpose of this study is examine which socioeconomic status groups are most at risk treatment interruption. <h3>Methods</h3> This cross-sectional internet monitor was conducted on December 22–26, 2020, when Japan experienced its third wave infection. Out a total 33,302 participants in the survey, 9510 (5392 males 4118 females) who responded that they required...
To evaluate whether magnetic resonance imaging (MRI) of the wrists and finger joints an analysis serologic autoantibodies are clinically meaningful for subsequent development rheumatoid arthritis (RA) in patients with undifferentiated (UA).A total 129 UA, a disease status formally confirmed by rheumatologist over period at least 1 year, were included. Gadolinium-diethylenetriamine-enhanced MRI both variables examined upon admission to our Early Arthritis Clinic Nagasaki University. After...
To investigate whether the frequency of peripheral blood (PB) regulatory T cells (Treg) correlates with clinical disease activity rheumatoid arthritis (RA).PB Treg cells, defined as CD4+CD25(high)CD127(low/-) population, were examined by flow cytometry in 48 patients RA, including 13 who had never received disease-modifying antirheumatic drugs (DMARD), 19 active receiving (n = 14) or 5) DMARD, and 16 DMARD whose was remission. The 28-joint Disease Activity Score (DAS28). association DAS28,...
Objective. We have tried to clarify the clinical importance of measurement serum type-I interferon (IFN) in patients with anti-melanoma differentiation-associated gene 5 Ab (MDA5 Ab)-positive dermatomyositis (DM). Methods. studied 30 DM: 10 were anti-MDA5 Ab-positive and 20 Ab-negative. At each patient's initial visit, IFN-α, IFN-β, interleukin 18 (IL-18), ferritin, titer measured using enzyme-linked immunosorbent assays (ELISAs). The associations between IFNs other variables examined....
Although glucocorticoids are effective for patients with IgG4-related disease, the treatment has not yet been standardized. Therefore, strategy should be established.Patients who fulfilled comprehensive diagnostic criteria definite disease were started on prednisolone (0.6 mg/kg body weight) dose reduced every two weeks. The subsequent maintenance and need determined individual patients. primary endpoint was complete remission (CR) rate at one year. Secondary endpoints included overall...
Takayasu arteritis (TAK) is a systemic vasculitis with severe complications that affects the aorta and its large branches. HLA-B*52 an established susceptibility locus to TAK. To date, there are still only limited number of reports concerning non-HLA loci We conducted genome-wide association study (GWAS) follow-up in total 633 TAK cases 5,928 controls. A 510,879 SNPs were genotyped, 5,875,450 imputed together HLA-B*52. Functional annotation significant loci, enhancer enrichment, pathway...
The precise cytokine networks in the serum of individuals with familial Mediterranean fever (FMF) that are associated its pathogenesis have been unknown. Here, we attempted to identify specific biomarkers diagnose or assess disease activity FMF patients. We measured levels 45 cytokines 75 patients and 40 age-matched controls by multisuspension array. "attack" "remission" was classified Japan College Rheumatology-certified rheumatologists according Tel Hashomer criteria. Cytokines were ranked...
To clarify the significance of immunometabolism in systemic lupus erythematosus (SLE), and to determine effect calcium/calmodulin-dependent protein kinase 4 (CaMK4) on T cell metabolism.Metabolomic profiling was performed using capillary electrophoresis mass spectrometry naive cells from MRL/lpr mice treated with anti-CD3/CD28 antibodies absence or presence a CaMK4 inhibitor (KN-93). The expression GLUT1 CD4+ healthy controls (n = 16), patients inactive SLE 13), active 14) examined by flow...
To compare the efficacy and safety of tofacitinib baricitinib in patients with RA a real-world setting. A total 242 who were treated (n = 161) or 81) enrolled. We evaluated between using multivariable analyses to avoid confounding. Their clinical disease activity AEs for 24 weeks. The mean (SD) DAS28-ESR change from baseline weeks was 1.57 (1.55) (tofacitinib) 1.46 (1.36) (baricitinib). There no significant difference response two groups (adjusted difference, 0.04; 95% CI, -0.35 0.28). not...
Low‐level laser (LLL) irradiation promotes proliferation of muscle satellite cells, angiogenesis and expression growth factors. Satellite factors play important roles in the regeneration muscle. The objective this study was to examine effect LLL on rat gastrocnemius recovering from disuse atrophy. Eight‐week‐old rats were subjected hindlimb suspension for 2 weeks, after which they released recovered. During recovery period, underwent daily (Ga–Al–As laser; 830 nm; 60 mW; total, 180 s) right...
Objective: To determine the association of distinct clinical subsets with myositis‐specific autoantibodies (MSAs) towards anti‐155/140‐kDa polypeptides [anti‐155/140 antibodies (Abs)], anti‐140‐kDa (anti‐140 Abs), and anti‐aminoacyl tRNA synthetases (ARS Abs) in Japanese patients dermatomyositis (DM).Methods: We compared features short‐term prognoses 30 DM whose serological status included these MSAs. The MSAs were determined by immunoprecipitation.Results: Anti‐155/140 Abs (n = 5), anti‐140...
Objective. We evaluated the significance of power Doppler ultrasonography (PDUS) score by comparing it with serum biomarkers and clinical disease activity.
Objective. The aim of this study was to investigate the characteristics power Doppler (PD) subclinical synovitis in patients with RA who achieve clinical remission free from physical synovitis.
Kidney podocytes and their slit diaphragms prevent urinary protein loss. T cells from patients with systemic lupus erythematosus display increased expression of calcium/calmodulin-dependent kinase IV (CaMKIV). The present study was undertaken to investigate the role CaMKIV in podocyte function nephritis (LN).We treated kidney IgG derived healthy individuals or LN then analyzed gene using a DNA microarray. localization by immunofluorescence staining, without silencing neonatal Fc receptor...
The purpose of this study was to examine the time-dependent changes in development joint capsule fibrosis and number myofibroblasts after immobilization, using a rat knee contracture model. Both joints were fixed full flexion for 1, 2, 4 weeks (immobilization group). Untreated rats bred each immobilization period (control Histological analysis performed evaluate amount density collagen capsule. type I III mRNA examined by situ hybridization. assessed immunohistochemical methods. In group,...