A5009970107- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Stroke Rehabilitation and Recovery
- Nutrition and Health in Aging
- Lung Cancer Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Cerebral Palsy and Movement Disorders
- Monoclonal and Polyclonal Antibodies Research
- Food Allergy and Anaphylaxis Research
- Dysphagia Assessment and Management
- Gastrointestinal Tumor Research and Treatment
- Frailty in Older Adults
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Dermatology and Skin Diseases
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Balance, Gait, and Falls Prevention
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- Cutaneous Melanoma Detection and Management
- Bacterial Infections and Vaccines
- Redox biology and oxidative stress
- Bone health and treatments
Tokai University
1994-2025
Yamato Municipal Hospital
2023-2024
Hebei Rehabilitation Hospital
2023-2024
Kio University
2021-2023
Itami City Hospital
2016-2022
Otsuka (Japan)
1999-2022
Otsuka Pharmaceutical (Spain)
2022
National Center for Geriatrics and Gerontology
2021
Kyoto Prefectural University of Medicine
2020-2021
Gifu Pharmaceutical University
2017-2019
<h3>Background:</h3> Mikulicz's disease (MD) has been considered as one manifestation of Sjögren's syndrome (SS). Recently, it also an IgG<sub>4</sub>-related disorder. <h3>Objective:</h3> To determine the differences between disorders including MD and SS. <h3>Methods:</h3> A study was undertaken to investigate patients with registered in Japan set up provisional criteria for new clinical entity IgG<sub>4</sub>-positive multiorgan lymphoproliferative (IgG<sub>4</sub>+MOLPS). The preliminary...
We have characterized a nontoxic mutant of cholera toxin (CT) as mucosal adjuvant in mice. The CT was made by substitution serine with phenylalanine at position 61 the A subunit (S61F), which resulted loss ADP ribosyltransferase activity and toxicity. Mice were intranasally immunized ovalbumin, tetanus toxoid, or influenza virus either alone together S61F, native CT, recombinant CT-B. these proteins plus S61F showed high serum titers protein-specific IgG IgA antibodies that comparable to...
We have assessed regulatory Th cell and cytokine responses in mice after oral immunization with recombinant Salmonella (BRD 847) expressing fragment C of tetanus toxoid, since little information is available to explain how these vectors induce mucosal IgA responses. A single dose BRD 847 elicited serum IgG2a anti-tetanus toxoid Ab To assess Th1-and Th2-type responses, CD4+ T cells from Peyer's patches spleen were restimulated vitro, cytokine-specific ELISPOT, ELISA, reverse transcriptase-PCR...
Cholera toxin (CT), the most commonly used mucosal adjuvant in experimental animals, is unsuitable for humans because of potent diarrhea-inducing properties. We have constructed two CT-A subunit mutants, e.g., serine→ phenylalanine at position 61 (S61F), and glutamic acid→ lysine 112 (E112K) by site-directed mutagenesis. Neither mutant CT (mCT), contrast to native (nCT), induced adenosine diphosphate-ribosylation, cyclic monophosphate formation, or fluid accumulation ligated mouse ileal...
Immune checkpoint inhibitor therapy has dramatically improved patient prognosis, and thereby transformed the treatment in various cancer types including esophageal squamous cell carcinoma (ESCC) past decade. Monoclonal antibodies that selectively inhibit programmed death-1 (PD-1) activity now become standard of care ESCC metastatic settings, a high expectation to provide clinical benefit during perioperative period. Further, anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)...
356 Background: We previously reported that postoperative complications after esophagectomy were significantly associated with poor long-term prognosis in the prospective randomized trial JCOG9907 (Ann Surg, 2017). JCOG1109 evaluated efficacy and safety of neoadjuvant docetaxel plus cisplatin 5-FU (DCF), radiation 5-fluorouracil (CF-RT) compared (CF) for locally advanced esophageal squamous cell carcinoma, demonstrated superiority DCF CF improving overall survival (OS). In this exploratory...
Streptococcus pneumoniae is a major respiratory mucosal pathogen affecting infants and children. Although polysaccharide-based vaccine has been useful in adult populations, it does not elicit protective immunity young Pneumococcal surface protein A (PspA) highly immunogenic produced by all strains of pneumoniae. Previous studies have shown that systemic immunization mice with PspA can against fatal pneumococcal infection. In this study, we demonstrated oral could immune responses When were...
In this study, we describe the interaction between cytokine and receptor (R) for activation proliferation of gamma delta T-cell receptor-positive T cells (gamma cells). isolated from murine intestinal intraepithelial lymphocytes (IELs) were separated into (Dim) (Bright) fractions according to intensity expression. The express low levels IL-2R IL-7R as shown by flow cytometry reverse transcriptase-PCR analysis, whereas did not either receptor. Our study also revealed that recombinant marine...
Seventy-nine adult patients with primary open-angle glaucoma (POAG) were randomly assigned to treatment by modified trabeculotomy ab externo (TAB) (n = 44) and trabeculectomy adjunctive mitomycin C (TMC) 35), the postoperative outcomes achieved these two techniques compared. With TAB, probability of successful intraocular pressure control 1 year postoperatively was .8644; TMC, .8432; difference is not significant (P .7956). However, complications such as corneal epithelial damage, bleb...
Nononcological prognostic factors in superficial esophageal squamous cell carcinoma (SESCC) patients remain unclear. The aim of this study is to evaluate the relationship between sarcopenia and surgical outcome with SESCC who had undergone definitive surgery. A total 194 thoracic esophagectomy three-field lymphadenectomy without neoadjuvant therapy at Tokai University Hospital January 2006 December 2015 were analyzed retrospectively. Manual tracing using CT imaging was used measure...
Abstract Background Subcortical ischemic vascular dementia, one of the major subtypes is characterized by lacunar infarcts and white matter lesions caused chronic cerebral hypoperfusion. In this study, we used a mouse model bilateral common carotid artery stenosis (BCAS) to investigate role B-cell translocation gene 2 (BTG2), an antiproliferation gene, in glial response Methods Btg2 −/− mice littermate wild-type control underwent BCAS or sham operation. Behavior phenotypes were assessed...
SARC-F is a screening tool for sarcopenia; however, it has not yet been established whether scores predict functional outcomes. Therefore, we herein investigated the relationship between and outcomes in stroke patients. The primary outcome present study was modified Rankin Scale (mRS) 3 months after stroke. poor examined using logistic regression analysis. Furthermore, applicability of to assessment analyzed based on area under receiver operating curve (ROC). Eighty-one out 324 patients...