A5101728890- Testicular diseases and treatments
- Prostate Cancer Treatment and Research
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Circadian rhythm and melatonin
- Telomeres, Telomerase, and Senescence
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- DNA Repair Mechanisms
- Renal cell carcinoma treatment
- Ovarian cancer diagnosis and treatment
- Urologic and reproductive health conditions
- Renal and related cancers
- Epigenetics and DNA Methylation
- Surgical site infection prevention
- Cancer therapeutics and mechanisms
- Urinary and Genital Oncology Studies
- Diagnosis and treatment of tuberculosis
- Renal and Vascular Pathologies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Metastasis and carcinoma case studies
- Appendicitis Diagnosis and Management
Kyoto Medical Center
2013-2023
National Hospital Organization Mito Medical Center
2006
Akita University
2001-2005
Kyoto University
1991-2001
Shiga University of Medical Science
2001
Background: Telomeres are specific structures located at the ends of chromosomes that help maintain chromosome stability. In most tissues, telomeres become shorter as cells divide, a phenomenon thought to be associated with limitations on normal cell proliferation. Almost all types cancer cells, including bladder express enzyme telomerase, which can or extend telomere length. Purpose: We examined telomerase activity in tumor specimens from cohort patients and determined whether could...
To investigate the possible role of genomic aberrations chromosome 9p21‐22 in tumorigenesis human renal cell carcinoma (RCC), 10 RCC lines, 55 primary RCCs and 5 metastatic lesions were studied by Southern blotting polymerase chain reaction‐based analysis. Nine lines showed a homozygous deletion MTS1/CDKN2/(p16) , while only 1 tumors had this deletion. Loss heterozygosity on was observed informative from patients with metastasis, but 4 31 (13%) without metastasis ( P = 0.025). Furthermore, 3...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 May 2001EXPRESSION PATTERNS OF CANCER TESTIS ANTIGENS IN TESTICULAR GERM CELL TUMORS AND ADJACENT TISSUE TAKESHI YUASA, KEISEI OKAMOTO, TAKAHIRO KAWAKAMI, MUTSUKI MISHINA, OSAMU OGAWA, and YUSAKU OKADA YUASATAKESHI YUASA , OKAMOTOKEISEI OKAMOTO KAWAKAMITAKAHIRO KAWAKAMI MISHINAMUTSUKI MISHINA OGAWAOSAMU OGAWA OKADAYUSAKU View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66415-4AboutFull TextPDF ToolsAdd to favoritesDownload...
Nobiletin and tangeretin (NoT) are flavonoids derived from the peel of Citrus depressa, they have been found to modulate circadian rhythms. Because nocturia can be considered a rhythm disorder, we investigated efficacy NoT for treating nocturia. A randomized, placebo-controlled, double-blind, crossover study was conducted. The trial registered with Japan Registry Clinical Trials (jRCTs051180071). Nocturia patients aged ≥50 years who presented more than 2 times on frequency–volume chart were...
The classic testicular tumor marker alpha-fetoprotein (AFP) is associated with nonseminomatous germ cell tumors, including embryonal carcinoma, yolk sac tumor, and teratoma. AFP not considered to be produced by pure seminoma. However, postmortem studies have demonstrated that 30 45% of patients who died seminoma initially diagnosed harbored metastases had an elevated serum AFP. We analyzed expression immunohistochemistry nested reverse transcription-polymerase chain reaction (RT-PCR) in 10...
It is known that many genomic and genetic alterations caused by aging or environmental factors are responsible for cancer development progression. XRCC1 involved in the repair of DNA single-strand breaks formed exposure to ionizing radiation alkylating agents. The objective this study was investigate association susceptibility testicular germ cell tumors with polymorphisms. Two polymorphisms XRCC1, Arg194Trp Arg399Gln, were genotyped 83 patients (TGCT) 87 male controls. Allelic imbalances...
Epigenetic alterations such as genomic imprinting might play an important role in human tumorigenesis, addition to specific genetic alterations. To clarify the of and/or epigenetic tumorigenesis testicular germ cell tumors (GCTs), we analyzed 40 primary and 3 metastatic GCTs with regard chromosomal losses their parental origin. A high incidence loss heterozygosity (LOH) was demonstrated on chromosomes 1p, 3p, 11p, 17p: 9/19 (47%), 18/39 (46%), 13/40 (33%) 20/36 (56%), respectively. However,...
Although excess production of androgens and glucocorticoids has often been observed in adrenocortical carcinomas, adenoma with such hormonal activity is rare. Herein, we report a 41-year-old woman who presented hyperandrogenemia mild autonomous cortisol secretion an undetectable level adrenocorticotropic hormone. Imaging demonstrated 6 cm left adrenal tumor. Histologic diagnosis the resected tumor was adenoma. Pre- post-operative serum samples were used for steroid profiling liquid...
Abstract Aldosterone-producing adenoma (APA) is 1 of the major subtypes primary aldosteronism (PA). Although most APA occurs unilaterally, bilateral APAs have rarely been documented. Because its rarity, optimal management patients with has not established. Here, we report a case that was successfully treated simultaneous cortical-sparing surgery. A 44-year-old Japanese woman referred to us for evaluation PA. She had typical clinical characteristics PA, including hypertension, hypokalemia,...
Background: Peritoneal tuberculosis (TB) is a relatively uncommon presentation of extrapulmonary TB. Early diagnosis peritoneal TB difficult because its nonspecific clinical manifestation such as abdominal pain, fever, or ascites. Especially early after surgery abdomen pelvis, these symptoms can be misdiagnosed septic peritonitis. There are few reports postoperative complication laparoscopic surgery. Here, we describe first case robot-assisted prostatectomy (RALP) with extended lymph node...
Purpose This retrospective study aimed to identify predictive factors and imaging features of adrenohepatic adhesion found during laparoscopic right adrenalectomy. Materials methods Altogether, 77 patients underwent adrenalectomy between January 2005 December 2018. Adrenohepatic was defined as strict that required either partial with coagulation residual tissue or hepatectomy accomplish complete resection. We assessed their surgical video records determine if present. Age, sex, body mass...
You have accessJournal of UrologyProstate Cancer: Detection & Screening (II)1 Apr 20131467 USEFULNESS OF MRI PRIOR TO PROSTATE NEEDLE BIOPSY IN PSA GRAY ZONE PATIENTS Norihiko Masuda, Yuma Sakura, Haruyuki Ohsugi, Yuki Kitamura, Yumi Manabe, Haruki Itoh, Mutsuki Mishina, and Hiroshi Okuno MasudaNorihiko Masuda Kyoto, Japan More articles by this author , SakuraYuma Sakura OhsugiHaruyuki Ohsugi KitamuraYuki Kitamura ManabeYumi Manabe Koto, ItohHaruki Itoh MishinaMutsuki Mishina OkunoHiroshi...