A5048345240- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- RNA modifications and cancer
- Dysphagia Assessment and Management
- Trauma Management and Diagnosis
- Pulmonary Hypertension Research and Treatments
- Gastroesophageal reflux and treatments
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Ultrasound in Clinical Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Medical Imaging and Pathology Studies
- Aortic Disease and Treatment Approaches
- Mechanical Circulatory Support Devices
East Carolina University
2014-2025
Society of Thoracic Surgeons
2015-2022
North Carolina State University
2022
University of Iowa
2007-2019
American College of Radiology
2016
American College of Financial Services
2016
University of Iowa Hospitals and Clinics
2005-2012
Sarcoma Oncology Center
2011
Michigan Medicine
2001-2005
University of Michigan
1995-2004
PURPOSE: A pilot study of 43 patients with potentially resectable esophageal carcinoma treated an intensive regimen preoperative chemoradiation cisplatin, fluorouracil, and vinblastine before surgery showed a median survival 29 months in comparison the 12-month 100 historical controls alone at same institution. We designed randomized trial to compare for this versus alone. MATERIALS AND METHODS: One hundred were receive either (arm I) or II) cisplatin 20 mg/m 2 /d on days 1 through 5 17 21,...
The relationship between gene expression measured at the mRNA level and corresponding protein is not well characterized in human cancer. In this study, we compared for a cohort of genes same lung adenocarcinomas. abundance 165 spots representing 98 individual was analyzed 76 adenocarcinomas nine non-neoplastic tissues using two-dimensional polyacrylamide gel electrophoresis. Specific polypeptides were identified matrix-assisted laser desorption/ionization mass spectrometry. For 85 samples,...
To review the authors' clinical experience with transhiatal esophagectomy (THE) and refinements in this procedure that have evolved.Increased use of THE during past two decades has generated controversy about merits safety approach compared transthoracic esophageal resection. The large provides a valuable basis for benchmarking data regarding procedure.The results were analyzed retrospectively using prospectively established resection database follow-up information on these patients.From...
Idiopathic pulmonary fibrosis (IPF) is a chronic and often fatal disorder. Fibroplasia deposition of extracellular matrix are dependent, in part, on angiogenesis. We postulated that an imbalance exists the expression angiogenic (IL-8) vs angiostatic (IFN-gamma-inducible protein (IP-10)) CXC chemokines, which favors net angiogenesis IPF. To test this hypothesis, we obtained open lung biopsies either from normal patients undergoing thoracic surgery for reasons other than interstitial disease...
The success of solid tumor growth and metastasis is dependent upon angiogenesis. Neovascularization within the regulated, in part, by a dual opposing system angiogenic angiostatic factors. We now report that IP-10, recently described factor, as potent factor regulates non-small cell lung cancer (NSCLC)-derived angiogenesis, growth, spontaneous metastasis. initially found significantly elevated levels IP-10 freshly isolated human NSCLC samples squamous carcinoma (SCCA). In contrast, were...
Morphologic assessment of lung tumors is informative but insufficient to adequately predict patient outcome. We previously identified transcriptional profiles that survival, and here we identify proteins associated with survival in adenocarcinoma. A total 682 individual protein spots were quantified 90 adenocarcinomas by using quantitative two-dimensional polyacrylamide gel electrophoresis analysis. leave-one-out cross-validation procedure the top 20 survival-associated Cox modeling...
We report here the role of CXC chemokine, epithelial neutrophil activating peptide (ENA-78), as an angiogenic factor in human non-small cell lung cancer (NSCLC). In freshly isolated specimens NSCLC, elevated levels ENA-78 were found that strongly correlated with vascularity tumors. a SCID mouse model NSCLC tumorigenesis, expression developing tumors tumor growth two different lines. Furthermore, passive immunization tumor-bearing mice neutralizing anti-ENA-78 antibodies reduced growth,...
Obliterative bronchiolitis (OB) is a devastating complication in lung transplantation. We postulated that the pathogenesis of OB mediated, part, by neutrophils. serially collected bronchoalveolar lavage (BAL) fluid from transplant recipients. Patients were divided into two groups depending on presence or absence OB. Samples patients who never developed further according to whether rejection was present. These samples labeled healthy rejection. sample obtained before (future OB) at time...
To determine the frequency of single lung metastasis, primary cancer, and benign lesions in patients with a solitary nodule extrapulmonary neoplasm.The authors evaluated electronic charts 149 an malignant neoplasm pulmonary nodule. The histologic characteristics were correlated those patient age smoking history.Patients carcinomas head neck, bladder, breast, cervix, bile ducts, esophagus, ovary, prostate, or stomach more likely to have bronchogenic carcinoma than metastasis (ratio, 25:3 for...
Angiogenesis is an absolute requirement for tumor growth beyond 2 mm 3 in size. The balance expression between opposing angiogenic and angiostatic factors controls the process. CXC chemokines are a group of chemotactic cytokines that possess disparate activity regulation angiogenesis. Nonsmall cell lung carcinoma (NSCLC) has imbalance ELR+ (angiogenic) compared with ELR- (angiostatic) favors angiogenesis progressive growth. We found level chemokine MIG (monokine induced by interferon gamma)...