A5053202166- Obesity, Physical Activity, Diet
- Thyroid Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Nutritional Studies and Diet
- Birth, Development, and Health
- Neuroendocrine Tumor Research Advances
- Thyroid Disorders and Treatments
- Sexual Differentiation and Disorders
- Body Composition Measurement Techniques
- Child Nutrition and Water Access
- Human Health and Disease
- Thyroid and Parathyroid Surgery
- Genetic Syndromes and Imprinting
- Head and Neck Anomalies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Frailty in Older Adults
- Bone health and osteoporosis research
- Adipokines, Inflammation, and Metabolic Diseases
- Genomic variations and chromosomal abnormalities
- Bone health and treatments
- Hip and Femur Fractures
- Neuroblastoma Research and Treatments
- Erythrocyte Function and Pathophysiology
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș
2016-2025
Spitalul Clinic Judetean Mures
2016-2020
Spitalul Clinic Judetean de Urgenta Târgu Mureş
2020
Spitalul Clinic de Recuperare
2020
<b><i>Aim: </i></b>High-quality national representative data on obesity in Romanian children are needed to shape public health policies. To provide<b> </b>a unified landscape prevalence, trends and other factors associated with underweight, overweight, aged 6-19 years, across the last decade (2006-2015). <b><i>Methods:</i></b> Using a common protocol, we selected published unpublished studies that measured schools between 2006 2015....
Differentiated thyroid cancer (DTC) is the most common endocrine malignancy, with genetic factors playing an important role in its development and progression. This study investigated association between nitric oxide synthase 3 (NOS3) gene polymorphisms (-786T>C or rs2070744 Glu298Asp c.894T>G rs1799983) clinical characteristics outcomes of DTC, aiming to evaluate their potential as biomarkers for prognosis. A case-control was conducted, enrolling 172 individuals from Endocrinology Clinics...
Abstract Objective Heterozygous germline loss-of-function variants in AIP are associated with young-onset growth hormone and/or prolactin-secreting pituitary tumours. However, the pathogenic role of c.911G&gt;A; p.(Arg304Gln) (R304Q) variant has been controversial. Recent data from public exome/genome databases show this is not infrequent. The objective work was to reassess pathogenicity R304Q based on clinical, genomic and functional assay data. Design, materials methods Data were...
There are no new national growth references for the Romanian population and current recommendations short stature evaluation is use of Swiss charts developed based on a longitudinal study.The aim present paper to synthetic children.We used local data from 9 studies with information height weight obtained between 1999 2016. Based their plausibility methodology six were selected generating National Synthetic Growth References Children specific described previously. The included 8407 subjects...
The need for parathyroidectomy remains high in the group of patients on long-term dialysis with medically refractory secondary hyperparathyroidism (sHPT). We aim to compare results after subtotal parathyroidectomies (sPtx) and total autotransplant (tPtx + AT) performed sHPT at a single referral centre.This prospective study comparatively analysed sPtx tPtx AT our department between February 2010 December 2014. followed-up both surgical techniques, respect main clinical symptoms, laboratory...
Background: Pediatric obesity continues to remain a serious health concern which has significantly increased the morbidity risk in adulthood. Recent studies have analyzed impact of two adipokines, RBP4 (retinol binding protein 4) and STRA6 (stimulated by retinoic acid 6) pediatric obese subjects with contradictory results. Methods: An observational study was conducted Endocrinology Departments, Targu-Mures, Romania, including 213 children between 5– 17 years age, divided into groups...
Resistance to first-generation somatostatin receptor ligand (fgSRL) treatment in acromegaly is common, making the identification of biomarkers that predict fgSRL response a desired goal. We conducted retrospective analysis on 21 patients with who underwent surgery and subsequent pharmacological treatment. Through immunohistochemistry (IHC), we assessed expression subtypes SSTR2 SSTR5, E-Cadherin, cytokeratin granulation pattern (sparsely or densely). Patients were divided into responders...
Abstract Sarcopenia, or age-related muscle loss is emerging as a major public health concern. A reduced quality of life (QoL) due to impaired physical performance associated with this disease has been evidenced in these individuals. Generic instruments, such Short Form 36 questionnaire (SF-36), do not accurately assess the impact sarcopenia on QoL. SarQol (Sarcopenia Quality Life) questionnaire, was first disease-specific addressing patients and recently designed for providing global picture...
Differences in sex development (DSD) are often correlated with a genetic etiology. This study aimed to assess the etiology of DSD patients following protocol testing.This prospectively investigated total 267 who presented Clinical Emergency Hospital for Children Cluj-Napoca between January 2012 and December 2019. Each patient was clinically, biochemically, morphologically evaluated. As first intervention, test included karyotype + SRY testing. A high value 17-hydroxyprogesterone found 39...
Parental history of osteoporosis is associated with an increased risk fracture. However, there are not many data on the mechanism action.Our objective was to determine if heredity influences fracture rate: independently or through bone mineral density; identify also strongest independent factors osteoporotic fractures among our study population.We processed 541 women outpatients average age 55 years, participating in screening program.Our results confirm that presence family significantly...
Abstract Background : Conflictual results regarding the relationship between plasmatic level of visfatin and obesity could be explained by influence gene variants involved in synthesis or action these hormones. Objectives The present study examined potential implication single nucleotide polymorphisms (SNPs) nicotinamide phosphoribosyltransferase (NAMPT) that encodes visfatin, obesity, a Romanian pediatric population. Method A case-control was conducted on group 213 children, divided into...
Abstract Background: Papillary thyroid microcarcinoma (PTMC) defines a group of papillary carcinomas, incidentally discovered, measuring 1 cm or less. The aim our study was to evaluate the incidence and pathological characteristics PTMCs in institution last 25 years, with special emphasis on prognostic factors related PTMCs. Material methods: We performed retrospective, cohort 255 PTMCs, registered Department Pathology, Tîrgu-Mureş Emergency County Hospital between 1990 2014. Results: A...