A5056184471- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Nutritional Studies and Diet
- Genomic variations and chromosomal abnormalities
- Birth, Development, and Health
- Genomics and Rare Diseases
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Congenital heart defects research
- Blood Pressure and Hypertension Studies
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Glutathione Transferases and Polymorphisms
- Child Nutrition and Water Access
- Diet, Metabolism, and Disease
- Body Composition Measurement Techniques
- RNA Interference and Gene Delivery
- Prostate Cancer Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Cardiomyopathy and Myosin Studies
- Pharmacogenetics and Drug Metabolism
Victor Babeș University of Medicine and Pharmacy Timișoara
2016-2025
Durham University
2025
National Institute for Research and Development in Informatics - ICI Bucharest
2025
UK Research and Innovation
2024
Innovate UK
2024
Camera de Comerț Industrie și Agricultură Timișoara
2017-2024
Medical Research Council
2024
Research England
2024
Imperial College London
2024
University of Zurich
2024
Few high-performance liquid chromatography–tandem mass spectrometry (LC-MS/MS) methods have been developed for the full quantitation of fatty acids from human plasma without derivatization. Therefore, we propose a method that requires fewer sample preparation steps, which can be used several polyunsaturated in plasma. The offers rapid, accurate, sensitive, and simultaneous quantification omega 3 (α-linolenic, eicosapentaenoic, docosahexaenoic acids) 6 (arachidonic linoleic using LC-MS/MS....
<b><i>Aim: </i></b>High-quality national representative data on obesity in Romanian children are needed to shape public health policies. To provide<b> </b>a unified landscape prevalence, trends and other factors associated with underweight, overweight, aged 6-19 years, across the last decade (2006-2015). <b><i>Methods:</i></b> Using a common protocol, we selected published unpublished studies that measured schools between 2006 2015....
Background: Nephrogenic diabetes insipidus (NDI) is defined as the inability of kidney to concentrate urine owing insensitivity distal nephron antidiuretic hormone, arginine vasopressin. NDI a heterogeneous rare autosomal dominant or X-linked disease. Objective: We present family with nephrogenic affecting three males in two generations. Methods: report boys NDI: 4-month-old infant who was treated for fever, vomiting, and failure thrive, his 10-year-old uncle (the mother’s brother), admitted...
Advancements in personalized medicine have revolutionized drug delivery, enabling tailored treatments based on genetic and molecular profiles. Non-viral vectors, such as polyurethane (PU)-based systems, offer promising alternatives for gene therapy. This study develops mathematical models to analyze PU degradation, DNA/RNA release kinetics, cellular interactions, optimizing their application theoretical utilized modeling numerical simulations PU-based focusing diffusion, uptake. Implemented...
Background/Objectives: Advancements in personalized medicine have revolutionized drug delivery, enabling tailored treatments based on genetic and molecular profiles. Non-viral vectors, such as polyurethane (PU)-based systems, offer promising alternatives for gene therapy. This study develops mathematical models to analyze PU degradation, DNA/RNA release kinetics, cellular interactions, optimizing their application Methods: theoretical utilized modeling numerical simulations PU-based focusing...
BREX ( B acte r iophage Ex clusion) systems, identified through shared identity with Pgl P hage G rowth L imitation) are a widespread, highly diverse group of phage defence systems found throughout bacteria and archaea. The varied Types harbour multiple protein subunits (between four eight) all encode conserved putative phosphatase (PglZ aka BrxZ) an equally conserved, ATPase (BrxC). Almost also contain site-specific methyltransferase (PglX BrxX). Despite having determined the structure...
Abstract Background Mutations in EFTUD2 were proven to cause a very distinct mandibulofacial dysostosis type Guion-Almeida (MFDGA, OMIM #610536). Recently, gross deletions and mutations determined syndromic esophageal atresia (EA), as well. We set forth find further conditions caused by the gene (OMIM *603892). Methods results performed exome sequencing two familial cases with clinical features overlapping MFDGA EA, but which previously assumed represent entities, syndrome atresia,...
Background In Romania (latitude 48°15'N to 43°40'N), vitamin D supplementation is common practice mostly in infants 0-1 year old. No published information available regarding epidemiological data on status the Romanian population for a wide age range and geographical territory. this context, we aimed evaluate seasonal variation of large population. Methods 6631 individuals from across had performed 7544 assessments (2012-2014) chain private laboratories. Vitamin (25-hydroxyvitamin D2...
Background: The plasma level of antipsychotics and their metabolites depends on the activity cytochrome P450 (CYP) system in liver. This research aims to test individual response variability atypical antipsychotic drugs, depending CYP2D6 enzyme. Methods: In a prospective, noninterventional study, we included 56 adolescents, 51.79% male, diagnosed with schizophrenia. patients underwent DNA sampling for genotyping SNP by RT-PCR CYP* allelic variants using Applied Bio-systems™ TaqMan® Assays...
Background and aim: The extract of ginger, obtained from the rhizome Zingiber officinale , contains 6-gingerol, 6-shogaol, 8-gingerol, 10-gingerol. It has many therapeutic effects such as being chemopreventive against stroke heart diseases, malabsorption, bacterial infections, indigestion, nausea, which have been observed since ancient times. main aim this study is to evaluate polyurethane (PU) a proper material for hollow nanoparticles' preparation. Methods: PU nanoparticles were by...
Prostate cancer (PCa) represents the most commonly diagnosed type of malignancy among men in Western European countries and second cause cancer-related deaths worldwide. Methylation CpG island has an important role prostate carcinogenesis progression. The purpose study was to analyse diagnostic value aberrant promoter hypermethylation gene for glutathione S-transferase P1 (GSTP1) plasma DNA discriminate between benign prostatic hyperplasia (BPH) patients by minimally invasive...
The benefit of reporting unsolicited findings in Next Generation Sequencing (NGS) related to cancer genes children may have implications for family members, nevertheless, could also cause distress. We aimed retrospectively investigate germline variants 94 implicated oncogenesis, patients referred NGS testing various rare genetic diseases and reevaluate the utility different classes pathogenicity. used silico prediction software classify conducted manual review examine frequencies 145 with...
Dilated cardiomyopathy (DCM) represents a group of disorders affecting the structure and function heart muscle, leading to high risk failure sudden cardiac death (SCD). DCM frequently involves an underlying genetic etiology. Genetic testing is valuable for stratification, treatment decisions, family screening. Romanian population data on etiology are lacking. We aimed investigate causes among adult patients at tertiary referral centers across country. Clinical investigations were performed...
Introduction Lifestyle factors, including inadequate eating patterns, emerge as a critical determinant of chronic disease. Apart from caring for patients, nurses should also take an active role in monitoring and managing their own health. Understanding the intricate relationship between nurses’ behavior health is crucial fostering holistic approach to healthcare, therefore our study aimed evaluate demographic factors influencing disease prevalence sample community Romania. Methods Between...
Background: Cardiomyopathies (CMs) represent a heterogeneous group of primary myocardial diseases characterized by structural and functional abnormalities. They one the leading causes cardiac transplantations death in young individuals. Clinically they vary from asymptomatic to symptomatic heart failure, with high risk sudden due malignant arrhythmias. With increasing availability genetic testing, significant number affected people are found have an underlying etiology. However, awareness...
Background and purpose Hypomyelinating leukodystrophies are a heterogeneous group of genetic disorders with wide spectrum phenotypes high rate genetically unsolved cases. Bi‐allelic mutations in NKX6‐2 were recently linked to spastic ataxia 8 hypomyelinating leukodystrophy. Methods Using combination homozygosity mapping, exome sequencing, detailed clinical neuroimaging assessment series new multicentre setting is described. Then, all reported those identified this study combined an in‐depth...
We aimed to assess the macular anatomy using spectral domain optical coherence tomography (SD-OCT), in children born preterm who had laser-treated retinopathy of prematurity (ROP), and investigate relationship between structural changes macula visual function.Thirty-seven 3-8 years old were included study two groups: 20 [(<34 weeks gestation, birthweight (BW) <2000 g)] ROP Neonatology Department, Municipal Clinical Emergency Hospital Timisoara, Romania; 17 controls (children at term, without...
Over the past decade, matrix-assisted laser desorption/ionization time‑of‑flight mass spectrometry (MALDI‑TOF MS) has been established as a valuable platform for microbial identification, and it is also frequently applied in biology clinical studies to identify new markers expressed pathological conditions. The aim of present study was assess potential using this approach classification cancer cell lines quantifiable method proteomic profiling cellular organelles. Intact protein extracts...