A5002262000- Chemical Reactions and Isotopes
- Ginger and Zingiberaceae research
- Essential Oils and Antimicrobial Activity
- Supramolecular Self-Assembly in Materials
- Cardiovascular Disease and Adiposity
- Air Quality and Health Impacts
- Treatment of Major Depression
- Piperaceae Chemical and Biological Studies
- Toxin Mechanisms and Immunotoxins
- Polysaccharides Composition and Applications
- Click Chemistry and Applications
- biodegradable polymer synthesis and properties
- Postharvest Quality and Shelf Life Management
- Mangiferin and Mango Extracts
- Polymer composites and self-healing
- Biomarkers in Disease Mechanisms
- Nutritional Studies and Diet
- Pharmacological Receptor Mechanisms and Effects
- Blood Pressure and Hypertension Studies
- Botanical Research and Chemistry
- Hormonal Regulation and Hypertension
- Phytochemical compounds biological activities
- Cholinesterase and Neurodegenerative Diseases
- Garlic and Onion Studies
- Tryptophan and brain disorders
Victor Babeș University of Medicine and Pharmacy Timișoara
2016-2025
Faculty (United Kingdom)
2015
Background: The volatile compounds present in rose extracts exhibit significant potential applications medicine and cosmetics due to their capacity enhance skin hydration barrier function, two factors that are crucial for anti-aging protection. antimicrobial, anti-inflammatory, analgesic properties of these also suggest utility oral health applications. aim the current study was obtain a new type polyurethane delivery system based on polyaddition process presence surfactant. Methods:...
Background and aim: The extract of ginger, obtained from the rhizome Zingiber officinale , contains 6-gingerol, 6-shogaol, 8-gingerol, 10-gingerol. It has many therapeutic effects such as being chemopreventive against stroke heart diseases, malabsorption, bacterial infections, indigestion, nausea, which have been observed since ancient times. main aim this study is to evaluate polyurethane (PU) a proper material for hollow nanoparticles' preparation. Methods: PU nanoparticles were by...
Background: Alzheimer's disease (AD) therapy is based on several natural and synthetic compounds that act as acetylcholinesterase (AChE) N-methyl-D-aspartate receptor (NMDA) ligands have limited efficiency in relieving AD symptoms. Recent studies show inhibitors isolated from Mentha spicata L. subsp. are promising for therapy. Objective: We aimed to identify novel more potent phytopharmaceutical treatment by taking into account the essential oil. Method: generated structure-activity...
Red chili peppers have been highly valued in gastronomy and traditional medicine since ancient times; it seems that is not just an ingredient for food but also a good remedy various medical conditions such as increased blood pressure high levels of serum triglycerides cholesterol, myocardial infarction, arthritis, migraines. The objective this study the characterization new carrier used encapsulated extract.Chili pepper extract was obtained physically entrapped inside polyurethane...
Background: Melanoma is known as the most dangerous form of skin cancer; whereas malignant choroidal melanoma an orphan disease common primary intraocular malignancy in adults. Literature suggests that consumption garlic and mistletoe leads to a reduced risk developing cancer. Objective: The aim this study was obtaining characterization polymer structures containing or extract. Methods: were obtained polyaddition process combined with spontaneous emulsification; they characterized by pH,...
The phytotherapy is based on the consume of fruits, vegetables and medicinal plants; they contain mixtures bioactive chemical substances (carotenoids, phenolic acids, flavonoids, coumarins, tannins, organosulfur compounds) with synergic effects treatment diseases. Nano- micro-carriers are very useful drug delivery systems which can improve transmembrane transfer natural extracts. In present study, betulin two birch bark extracts were encapsulated inside polyurethane microstructures....
Calcium channel blockers (CCB) are widely used in cardiovascular medicine expressing high hopes upon decreasing risk, morbidity and mortality. Here, the potency of CCBs on 58 Romanian asymptomatic hypertensive patients, with no atherothrombotic disease, was studied by clinical silico methods. In our study, arterial elasticity/stiffness assessed; anthropometric, metabolic (lipidic) parameters were quantified. We concluded that lercanidipine 10 mg once daily, during three weeks, is able to...
Background: Risk factors represented by genetic, environmental or social stress induce severe psychiatric disorders such as depression, schizophrenia neurodegenerative processes. Antipsychotics are required for the pharmacological treatments of these disorders, but their molecular mechanisms and especially those involved in protecting nervous system, still unclear. The latest strategies neuroscience field consider very important discovery new applications, promoting neurite growth...
Background: Few HIV-1fusion and replication inhibitors were developed, with limited clinical applications because of their short half-life, drug resistance cross-reactivity preexisting antibodies in HIV-infected patients. Objective: These limitations call for new strategies the development next anti-HIV-1 drugs. Among anti-gp41HIV-1 inhibitors, short-peptides exhibit high antiviral activity but mechanism action at molecular level has not been sufficiently addressed. Method: We report potent...
The monoclonal antibody bevacizumab, which neutralizes vascular endothelial growth factor, significantly affects the migration, survival, and proliferation of cells - all are critical for spread tumors. current study s objective was to create polyurethane structures that more soluble in water so they may be employed as this active agent transmembrane carrier. A polymer drug delivery system created using an aliphatic isocyanate a combination ether ester polyols, resulting suitable release...
Background: Depression associated with asthma enhances asthma-related morbidity and mortality. While antidepressants (AD) are prescribed in depression, β2-adrenergic agonists (BAA) xanthines used asthma. Asthma treatment side effects include depression suicidal ideation. Objective: Here, we identified a possible mechanism of BAA to induce depressant or antidepressant responses by advanced methods computational pharmacology correlated clinical studies. Methods: Based on 18 AD, 7 two...
Background: At the cellular level, normal chromosome segregation is ensured by intrinsic mechanics of mitosis and proper functioning error-checking spindle assembly checkpoint (SAC). Protein Mad1 (the mitotic arrest-deficient), an important SAC component, plays a crucial role in avoiding aneupoidy, state leading to genetic diseases such as cancer or bipolar disorder. Objective: To clarify aneuploidy diseases, number wild type (wt) mutant proteins have been studied, but till now process not...
Abstract Hydrogen sulphide, a highly toxic gas, can be used in crenotherapy to balance all metabolic processes (minerals, fats and proteins). The main aims of this study were correlate the weather characteristics with atmospheric H 2 S level evaluate antidote activity B12 Vitamin case prolonged exposure compound. 46 volunteers, people from medical staff an important Romanian thermal water spring spa, professional at S, enrolled study; numerical data about their blood pressure, concentration...