A5041865248- Spectroscopy and Quantum Chemical Studies
- Terahertz technology and applications
- Protein Structure and Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Lipid Membrane Structure and Behavior
- Glycosylation and Glycoproteins Research
- Antimicrobial Peptides and Activities
- Computational Drug Discovery Methods
- Advanced Biosensing Techniques and Applications
- Ion Channels and Receptors
- Nanoparticles: synthesis and applications
- Microplastics and Plastic Pollution
- Nuclear physics research studies
- Biochemical Analysis and Sensing Techniques
- Synthesis and biological activity
- Analytical Chemistry and Chromatography
- T-cell and Retrovirus Studies
- Quantum Chromodynamics and Particle Interactions
- Quantum Dots Synthesis And Properties
- Plant Stress Responses and Tolerance
- Curcumin's Biomedical Applications
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Microtubule and mitosis dynamics
- Molecular spectroscopy and chirality
University of Bucharest
2016-2025
Cook County Health and Hospitals System
2025
Spitalul Clinic de Psihiatrie Alexandru Obregia
2022-2024
Institutul Oncologic Bucuresti
2023
Universitatea Națională de Știință și Tehnologie Politehnica București
2015
Victor Babeș University of Medicine and Pharmacy Timișoara
2015
Alexandru Ioan Cuza University
2000-2012
University of Illinois Chicago
2010
German Cancer Research Center
2002-2004
Heidelberg University
1999-2004
Biofilms formed by bacterial cells are associated with drastically enhanced resistance against most antimicrobial agents, contributing to the persistence and chronicization of microbial infections therapy failure. The purpose this study was combine unique properties magnetic nanoparticles activity three essential oils obtain novel nanobiosystems that could be used as coatings for catheter pieces an improved Staphylococcus aureus Klebsiella pneumoniae clinical strains adherence biofilm...
Microplastics (plastic particles < 5 mm) are ubiquitous pollutants that have the ability to carry microbiota, including pathogens. Microbial adhesion is usually a sign of pathogenicity; thus, we investigated adherent microbiota found on 4 mm nylon strips, which were ingested and excreted by wild fish specimens. Retention times recorded polymer analysis samples was performed, showed no signs degradation, nor did their controls, represented strips submerged in same water tanks. Both...
Glycosylation is a critical post-translational modification that influences protein folding, stability and function. While extensively studied in extracellular intracellular regions, glycosylation within transmembrane (TM) regions at membrane interfaces remains poorly understood. This study aimed to map O- N-glycosylation sites these using comprehensive database search structural validation where possible. Extensive searches revealed range of proteins. Only the falling TM interface...
Abstract Context Sleep health is multidimensional. While studies have shown associations between certain sleep dimensions and in type 1 diabetes (T1D), global has rarely been considered. Objective To examine the individual multidimensional (MSH) on glycemic control self-reported outcomes T1D. Methods Data from 116 adults with T1D participating a study (NCT04506151) were analyzed. satisfaction alertness assessed by questionnaires. timing, efficiency, duration, regularity derived 7-day...
During an Antarctic expedition that took place in December 2010–January 2011 the East coastal region, soil samples were collected aseptic conditions and stored for over a decade freezers at −20 °C. Due to shortly afterward passing of researcher charge, Teodor Negoiță, remained unintentionally frozen long period made available research 13 years later. A chemical analysis as well screening viable microbial presence was performed; conducted via inductively coupled plasma atomic emission...
This is the first study, to our knowledge, performed on a significant number of strains (79 carbapenem-resistant Enterobacteriaceae and 84 non-fermenting Gram-negative rods, GNRs) isolated from tissue samples taken patients in intensive care units two large hospitals Bucharest, Romania, between 2011 2012. The results revealed high prevalence great diversity carbapenemase genes (CRG), both fermenting strains. molecular screening GNRs presence worldwide-distributed CRGs (i.e. blaOXA-48...
Abstract Due to their outstanding properties, quantum dots (QDs) received a growing interest in the biomedical field, but it is of major importance investigate and understand interaction with biomolecules. We examined stability silicon QDs time evolution – protein corona formation various biological media (bovine serum albumin, cell culture medium without or supplemented 10% fetal bovine serum-FBS). Changes secondary structure BSA were also investigated over time. Hydrodynamic size zeta...
Energy and angular distributions of electron beams with different energies were simulated by Monte Carlo calculations. These generated the NOVAC7® system (Hitesys, Italy), a mobile accelerator specifically dedicated to intra-operative radiation therapy (IORT). The beam simulations verified comparing measured dose corresponding calculated distributions. As expected, considerable difference was observed in energy between IORT studied present work produced conventional accelerators for non-IORT...
Abstract The transient receptor potential ankyrin type 1 (TRPA1) channel belongs to the TRP superfamily of ion channels. TRPA1 is a membrane protein with multiple functions able respond noxious stimuli, reactive oxygen species, inflammatory cytokines or pungent substances, and it participates in pain signalling, taste, inflammation various steps tumorigenic process. To date, no reports have addressed expression function pancreatic ductal adenocarcinoma (PDAC) cells. This work endogenous...
The enhancement of seed germination by using nanoparticles (NPs) holds the potential to elicit synthesis more desired compounds with important biomedical applications, such as preventing protein glycation, which occurs in diabetes. Here, we used 7 nm and 100 ZnO 4.5 16.7 Fe
Background: Alzheimer's disease (AD) therapy is based on several natural and synthetic compounds that act as acetylcholinesterase (AChE) N-methyl-D-aspartate receptor (NMDA) ligands have limited efficiency in relieving AD symptoms. Recent studies show inhibitors isolated from Mentha spicata L. subsp. are promising for therapy. Objective: We aimed to identify novel more potent phytopharmaceutical treatment by taking into account the essential oil. Method: generated structure-activity...
Plastic debris is considered an emerging aquatic pollutant as alarming number of reports are indicating the environmental contamination with such agents. Ichthyofauna has been subjected to increasing plastic pollution over past years, which led detrimental effects in food chain, and consequently general health ecosystems. In this study, we exposed juvenile specimens Oreochromis niloticus polyvinyl chloride (PVC) powder form. Specimens water parameters were closely monitored for 40 days...
Antidepressants are psychiatric agents used for the treatment of different types depression, being at present amongst most commonly prescribed drugs, while their effectiveness and adverse effects still subject many studies. To reduce inefficiency known antidepressants caused by side-effects, research efforts have recently focused on development improved strategies new drug design. For this reason it is necessary to apply very fast precise techniques, such as QSAR (Quantitative...
Transient receptor potential melastatin 8 (TRPM8), a membrane ion channel, is activated by thermal and chemical stimuli. In pancreatic ductal adenocarcinoma, TRPM8 required for cell migration, proliferation, senescence associated with tumor size adenocarcinoma stages. Although the underlying mechanisms of these processes have yet to be described, this cation-permeable channel has been proposed as an oncological target. study, glycosylation status was shown affect calcium uptake. expressed in...