Ionela Cristina Nica

ORCID: 0000-0003-4883-3346
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About
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Research Areas
  • Bone Tissue Engineering Materials
  • Nanoparticles: synthesis and applications
  • Advanced Nanomaterials in Catalysis
  • Graphene and Nanomaterials Applications
  • Nanoparticle-Based Drug Delivery
  • Dental Implant Techniques and Outcomes
  • Orthopaedic implants and arthroplasty
  • Dental materials and restorations
  • Biosensors and Analytical Detection
  • Electrospun Nanofibers in Biomedical Applications
  • Laser-Ablation Synthesis of Nanoparticles
  • Polymer Surface Interaction Studies
  • Hydrogels: synthesis, properties, applications
  • Bacterial biofilms and quorum sensing
  • Advanced Drug Delivery Systems
  • TiO2 Photocatalysis and Solar Cells
  • Corrosion Behavior and Inhibition
  • Cystic Fibrosis Research Advances
  • Skin Protection and Aging
  • Magnesium Alloys: Properties and Applications
  • Cancer Treatment and Pharmacology
  • Dyeing and Modifying Textile Fibers
  • Nigella sativa pharmacological applications
  • Titanium Alloys Microstructure and Properties
  • Medical and Biological Ozone Research

University of Bucharest
2015-2025

Consejo Nacional de Investigaciones Científicas y Técnicas
2022

Universidad Nacional de Córdoba
2022

Academy of Romanian Scientists
2021

Annual Reviews
2018

Textile materials can be easily used as a support for the nano-decoration with active particles in order to gain new features such self-cleaning, antimicrobial efficiency, water repellency, mechanical strength, color change and protection against ultraviolet radiations. In this context, our present research reports fabrication characterization (physico-chemical analysis surface morphology) of cotton fabrics treated reduced graphene oxide decorated two types TiO 2 nanoparticles co-doped 1%...

10.1177/1528083718779447 article EN Journal of Industrial Textiles 2018-05-24

Inflammatory bowel disease (IBD) represents a group of chronic autoimmune and idiopathic disorders that are characteristic industrialized countries. In contrast to drug therapies, which exert several side effects, herbal remedies have constantly attracted the attention researchers. Therefore, in present study, mother tincture (MT) from fresh, young, non-woody Thuja occidentalis L. branches with leaves was obtained using distillation-based techniques. Further, this used assess its vitro vivo...

10.3390/antiox8090416 article EN cc-by Antioxidants 2019-09-19

In the context of inefficient antibiotics, antibacterial alternatives are urgently needed to stop increasing resistance rates in pathogens. This study reports fabrication and characterization four promising magnetite-based antibiotic delivery systems for ENT (ear, nose throat) applications. Magnetite nanoparticles were functionalized with streptomycin neomycin some entrapped polymeric spheres. The obtained nanomaterials stable, spherical morphology, their size ranging from ~2.8 ~4.7 nm...

10.3390/antibiotics11050623 article EN cc-by Antibiotics 2022-05-05

Due to its excellent bone-like mechanical properties and non-toxicity, magnesium (Mg) alloys have attracted great interest as biomaterials for orthopaedic applications. However, their fast degradation rate in physiological environments leads an acute inflammatory response, restricting use biodegradable metallic implants. Endowing Mg-based with immunomodulatory can help trigger a desired immune response capable of supporting favorable healing process. In this study, electrospun...

10.3390/ijms22020909 article EN International Journal of Molecular Sciences 2021-01-18

Globally, cancer is the second most common cause of death, and Europe accounts for almost 25% global burden, although its people make up only 10% world’s population. Conventional systemically administered anti-cancer drugs come with important drawbacks such as inefficiency due to poor bioavailability improper biodistribution, severe side effects associated low therapeutic indices, development multidrug resistance. Therefore, smart nano-engineered targeted drug-delivery systems tailored...

10.3390/pharmaceutics13091356 article EN cc-by Pharmaceutics 2021-08-28

The recurrence of bone cancer poses severe complications, particularly after orthopedic surgery, necessitating advanced biomaterials with dual functionality. This study develops nanostructured coatings composed hydroxyapatite, carboplatin, and quercetin, designed to enhance regeneration while delivering localized therapy. These present a promising solution for hip endoprostheses, addressing osteointegration tumor prevention simultaneously. Hydroxyapatite was synthesized characterized using...

10.3390/coatings15040489 article EN Coatings 2025-04-20

This study presents the preparation of hybrid iron oxide nanocomposites through a two-step process combining microfluidic-assisted synthesis and post-synthetic surface modification. Fe3O4 nanoparticles were synthesized simultaneously functionalized with salicylic acid using three-dimensional vortex-type microfluidic chip, enabling rapid uniform particle formation. The resulting Fe3O4/SA nanostructures further modified either silver or copper to form enhanced antimicrobial functionality....

10.3390/nano15090637 article EN cc-by Nanomaterials 2025-04-22

Implant-associated infections represent challenging complications following orthopedic surgeries, with spinal fixation procedures being particularly linked increased risks. Thus, urgent research is required to develop enhanced solutions avoid bacterial colonization, associated implant failure, and severe issues. Our study based on the laser coating of surfaces a composite mixture PLA/Fe3O4@CEF that can fight against infectious agents preserve their activity for prolonged time. In present...

10.3390/coatings15050584 article EN Coatings 2025-05-14

TiO2-based photocatalysts were obtained during previous years in order to limit pollution and ease human daily living conditions due their special properties. However, obtaining biocompatible is still a key problem, the mechanism of toxicity recently received increased attention. Two types TiO2 nanoparticles co-doped with 1% iron nitrogen (TiO2-1% Fe–N) atoms synthesized hydrothermal at pH 8.5 (HT1) 5.5 (HT2), antimicrobial activity cytotoxic effects exerted on pulmonary dermal fibroblasts...

10.3390/ijms18020249 article EN International Journal of Molecular Sciences 2017-01-25

Our research was focused on the evaluation of photocatalytic and antimicrobial properties, as well biocompatibility cotton fabrics coated with fresh reused dispersions nanoscaled TiO2-1% Fe-N particles prepared by hydrothermal method post-annealed at 400 °C. The powders were characterized X-ray diffraction (XRD), Mössbauer spectroscopy photoelectron spectroscopy. textiles doped TiO2 scanning electron microscopy energy dispersive analyses, their effect trichromatic coordinates materials...

10.3390/ma9090789 article EN Materials 2016-09-21

The implant-related infection as a consequence of bacterial adherence and biofilm formation remains one the main causes implant failure. Grace to recent advances in materials science, their great mechanical properties biocompatibility (both vitro vivo), antibacterial coatings have gradually become primary component global strategy for preventing microbial colonization. In present work, novel containing hydroxyapatite nanoparticles doped with two different concentrations samarium (5SmHAp...

10.3390/coatings11101185 article EN Coatings 2021-09-29

With the increasing use of invasive, interventional, indwelling, and implanted medical devices, healthcare-associated infections caused by pathogenic biofilms have become a major cause morbidity mortality. Herein, we present fabrication, characterization, in vitro evaluation biocompatibility anti-biofilm properties new coatings based on Fe3O4 nanoparticles (NPs) loaded with usnic acid (UA) ceftriaxone (CEF). Sodium lauryl sulfate (SLS) was employed as stabilizer modulator polarity,...

10.3390/antibiotics13070631 article EN cc-by Antibiotics 2024-07-07

The development of innovative technologies to modify natural textiles holds an important impact for medical applications, including the prevention contamination with microorganisms, particularly in hospital environment. In our study, Fe and N co-doped TiO2 nanoparticles have been obtained via hydrothermal route, at moderate temperature, followed by short thermal annealing 400 °C. These particles were used impregnate polyester (PES) materials which evaluated their morphology, photocatalytic...

10.3390/nano6110214 article EN cc-by Nanomaterials 2016-11-15

The occurrence of opportunistic local infections and improper integration metallic implants results in severe health conditions. Protective tunable coatings represent an attractive challenging selection for improving the devices’ biofunctional performances to restore or replace bone tissue. Composite materials based on hydroxyapatite (HAp), Kanamycin (KAN), fibroblast growth factor 2 (FGF2) are herein proposed as multifunctional hard tissue implants. superior cytocompatibility obtained...

10.3390/antibiotics10020160 article EN Antibiotics 2021-02-05

Biofilms represent a common and increasingly challenging problem in healthcare practices worldwide, producing persistent difficult to manage infections. Researchers have started developing antibiotic-free treatment alternatives order decrease the risk of resistant microbial strain selection for efficient management antibiotic tolerant biofilm The present study reports fabrication characterization magnetite-based nanostructured coatings biofilm-resistant surfaces. Specifically, magnetite...

10.3390/antibiotics10101269 article EN cc-by Antibiotics 2021-10-19

The present paper aims atincreasing the bioperformance of implantable Ti50Zr alloy using zwitterionic cysteine drug coating. Aspects such as stability, biocompatibility, and antibacterial effects were investigated with help various methods infrared spectroscopy (FT-IR), scanning electronic microscopy (SEM), electrochemical methods, contact angle determinations cell response. experimental data coating indicate existence a hydration layer due to hydrophilic groups evidenced in FT-IR which is...

10.3390/pharmaceutics10040220 article EN cc-by Pharmaceutics 2018-11-08

Dextran coated cerium doped hydroxyapatite (Ca10-xCex(PO4)6(OH)2), with x = 0.05 (5CeHAp-D) and 0.1 (10CeHAp-D) were deposited on Si substrates by radio frequency magnetron sputtering technique for the first time. The morphology, composition, structure of resulting coatings examined scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDX), atomic force (AFM), metallographic (MM), Fourier transform infrared (FTIR), glow discharge optical emission (GDOES), respectively....

10.3390/polym14091826 article EN Polymers 2022-04-29

Graphene is widely used in nanotechnologies to amplify the photocatalytic activity of TiO2, but development TiO2/graphene composites imposes assessment their risk human and environmental health. Therefore, reduced graphene oxide was decorated with two types TiO2 particles co-doped 1% iron nitrogen, one them being obtained by a simultaneous precipitation Ti3+ Fe3+ ions achieve uniform distribution, other after sequential these cations for higher concentration on surface. Physico-chemical...

10.3390/nano7090279 article EN cc-by Nanomaterials 2017-09-19

The primary focus of the paper is fabrication nanotubes via a two steps anodizing procedure on TiZr substrate followed subsequent annealing treatments and their effect surface biocompatibility. step process optimized for obtaining uniform ordered nanotubular structures, that are then annealed in air or reduced an Ar/H2 environment. high aspect ratio structures (diameter 160 nm, length 9.4 μm) maintained morphology after reduction. While thermal burned-off fluoride, they converted tubes to...

10.1016/j.jmrt.2019.09.049 article EN cc-by-nc-nd Journal of Materials Research and Technology 2019-10-10

TiO 2 nanowires are fabricated by electrospinning on Ti50Zr alloy, changing the elaboration conditions. The surface covered with is characterized performing scanning electronic microscopy and contact angle measurements. best from point of view organization chosen based experimental electrochemical stability tested in Fusayama saliva. response HGF‐1 gingival fibroblasts cells established discussed. Cellular evaluated cell viability, lactate dehydrogenase test, nitric oxide level interleukines...

10.1002/maco.201810317 article EN Materials and Corrosion 2018-07-19

The advancement of nanotechnology in the last decade has developed an abundance novel and intriguing TiO2-based nanomaterials that are widely used many sectors, including industry (as a food additive colorant cosmetics, paints, plastics, toothpaste) biomedicine (photoelectrochemical biosensing, implant coatings, drug delivery, new emerging antimicrobial agents). Therefore, increased use engineered raised serious concern about human exposure their unexpected cytotoxic effects. Since...

10.3390/ijms22179627 article EN International Journal of Molecular Sciences 2021-09-06

Fish are able to accumulate by ingestion various contaminants of aquatic environment, with negative consequences on their intestine, being continuously threatened worldwide heavy metals, pesticides and antibiotics resulted from the human activities. Consequently, health other species can be affected eating contaminated fish meat. In this context, our study aimed perform a comparison between changes in intestine samples Carassius gibelio individuals collected different artificial lakes...

10.3390/ijerph19127510 article EN International Journal of Environmental Research and Public Health 2022-06-19

The paper studies the electrochemical stability in physiological serum and cell response of nanostrucures obtained on Zr by anodizing electrolytes containing fluorinated ethylene glycol various amounts K 2 CO 3 . SEM analysis revealed that porous nanostructure formation is greatly influenced concentrations electrolyte tipping balance between oxide dissolution during process. porosities samples were evaluated from polarization resistances recorded serum. Chronoamperometric measurements...

10.1002/maco.201710017 article EN Materials and Corrosion 2018-02-27

Over the past decades, nanotechnology has increasingly developed and reached to monopolize almost all of human activity areas.Materials with nanoscaled dimensions are not only for technological or medical purposes, but also, they can be found in daily commercial products.So, nanoparticles' applications a welldefined place our modern life.Almost 70% global pigment production is based on titanium dioxide (TiO 2 ), which represents also one top five nanoparticles used consumer products.TiO...

10.31178/rbbs.2019.2.1.1 article EN Reviews in Biological and Biomedical Sciences 2018-08-22
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