- Bone Tissue Engineering Materials
- Nanoparticles: synthesis and applications
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Biosensors and Analytical Detection
- Electrospun Nanofibers in Biomedical Applications
- Laser-Ablation Synthesis of Nanoparticles
- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- Bacterial biofilms and quorum sensing
- Advanced Drug Delivery Systems
- TiO2 Photocatalysis and Solar Cells
- Corrosion Behavior and Inhibition
- Cystic Fibrosis Research Advances
- Skin Protection and Aging
- Magnesium Alloys: Properties and Applications
- Cancer Treatment and Pharmacology
- Dyeing and Modifying Textile Fibers
- Nigella sativa pharmacological applications
- Titanium Alloys Microstructure and Properties
- Medical and Biological Ozone Research
University of Bucharest
2015-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2022
Universidad Nacional de Córdoba
2022
Academy of Romanian Scientists
2021
Annual Reviews
2018
Textile materials can be easily used as a support for the nano-decoration with active particles in order to gain new features such self-cleaning, antimicrobial efficiency, water repellency, mechanical strength, color change and protection against ultraviolet radiations. In this context, our present research reports fabrication characterization (physico-chemical analysis surface morphology) of cotton fabrics treated reduced graphene oxide decorated two types TiO 2 nanoparticles co-doped 1%...
Inflammatory bowel disease (IBD) represents a group of chronic autoimmune and idiopathic disorders that are characteristic industrialized countries. In contrast to drug therapies, which exert several side effects, herbal remedies have constantly attracted the attention researchers. Therefore, in present study, mother tincture (MT) from fresh, young, non-woody Thuja occidentalis L. branches with leaves was obtained using distillation-based techniques. Further, this used assess its vitro vivo...
In the context of inefficient antibiotics, antibacterial alternatives are urgently needed to stop increasing resistance rates in pathogens. This study reports fabrication and characterization four promising magnetite-based antibiotic delivery systems for ENT (ear, nose throat) applications. Magnetite nanoparticles were functionalized with streptomycin neomycin some entrapped polymeric spheres. The obtained nanomaterials stable, spherical morphology, their size ranging from ~2.8 ~4.7 nm...
Due to its excellent bone-like mechanical properties and non-toxicity, magnesium (Mg) alloys have attracted great interest as biomaterials for orthopaedic applications. However, their fast degradation rate in physiological environments leads an acute inflammatory response, restricting use biodegradable metallic implants. Endowing Mg-based with immunomodulatory can help trigger a desired immune response capable of supporting favorable healing process. In this study, electrospun...
Globally, cancer is the second most common cause of death, and Europe accounts for almost 25% global burden, although its people make up only 10% world’s population. Conventional systemically administered anti-cancer drugs come with important drawbacks such as inefficiency due to poor bioavailability improper biodistribution, severe side effects associated low therapeutic indices, development multidrug resistance. Therefore, smart nano-engineered targeted drug-delivery systems tailored...
The recurrence of bone cancer poses severe complications, particularly after orthopedic surgery, necessitating advanced biomaterials with dual functionality. This study develops nanostructured coatings composed hydroxyapatite, carboplatin, and quercetin, designed to enhance regeneration while delivering localized therapy. These present a promising solution for hip endoprostheses, addressing osteointegration tumor prevention simultaneously. Hydroxyapatite was synthesized characterized using...
This study presents the preparation of hybrid iron oxide nanocomposites through a two-step process combining microfluidic-assisted synthesis and post-synthetic surface modification. Fe3O4 nanoparticles were synthesized simultaneously functionalized with salicylic acid using three-dimensional vortex-type microfluidic chip, enabling rapid uniform particle formation. The resulting Fe3O4/SA nanostructures further modified either silver or copper to form enhanced antimicrobial functionality....
Implant-associated infections represent challenging complications following orthopedic surgeries, with spinal fixation procedures being particularly linked increased risks. Thus, urgent research is required to develop enhanced solutions avoid bacterial colonization, associated implant failure, and severe issues. Our study based on the laser coating of surfaces a composite mixture PLA/Fe3O4@CEF that can fight against infectious agents preserve their activity for prolonged time. In present...
TiO2-based photocatalysts were obtained during previous years in order to limit pollution and ease human daily living conditions due their special properties. However, obtaining biocompatible is still a key problem, the mechanism of toxicity recently received increased attention. Two types TiO2 nanoparticles co-doped with 1% iron nitrogen (TiO2-1% Fe–N) atoms synthesized hydrothermal at pH 8.5 (HT1) 5.5 (HT2), antimicrobial activity cytotoxic effects exerted on pulmonary dermal fibroblasts...
Our research was focused on the evaluation of photocatalytic and antimicrobial properties, as well biocompatibility cotton fabrics coated with fresh reused dispersions nanoscaled TiO2-1% Fe-N particles prepared by hydrothermal method post-annealed at 400 °C. The powders were characterized X-ray diffraction (XRD), Mössbauer spectroscopy photoelectron spectroscopy. textiles doped TiO2 scanning electron microscopy energy dispersive analyses, their effect trichromatic coordinates materials...
The implant-related infection as a consequence of bacterial adherence and biofilm formation remains one the main causes implant failure. Grace to recent advances in materials science, their great mechanical properties biocompatibility (both vitro vivo), antibacterial coatings have gradually become primary component global strategy for preventing microbial colonization. In present work, novel containing hydroxyapatite nanoparticles doped with two different concentrations samarium (5SmHAp...
With the increasing use of invasive, interventional, indwelling, and implanted medical devices, healthcare-associated infections caused by pathogenic biofilms have become a major cause morbidity mortality. Herein, we present fabrication, characterization, in vitro evaluation biocompatibility anti-biofilm properties new coatings based on Fe3O4 nanoparticles (NPs) loaded with usnic acid (UA) ceftriaxone (CEF). Sodium lauryl sulfate (SLS) was employed as stabilizer modulator polarity,...
The development of innovative technologies to modify natural textiles holds an important impact for medical applications, including the prevention contamination with microorganisms, particularly in hospital environment. In our study, Fe and N co-doped TiO2 nanoparticles have been obtained via hydrothermal route, at moderate temperature, followed by short thermal annealing 400 °C. These particles were used impregnate polyester (PES) materials which evaluated their morphology, photocatalytic...
The occurrence of opportunistic local infections and improper integration metallic implants results in severe health conditions. Protective tunable coatings represent an attractive challenging selection for improving the devices’ biofunctional performances to restore or replace bone tissue. Composite materials based on hydroxyapatite (HAp), Kanamycin (KAN), fibroblast growth factor 2 (FGF2) are herein proposed as multifunctional hard tissue implants. superior cytocompatibility obtained...
Biofilms represent a common and increasingly challenging problem in healthcare practices worldwide, producing persistent difficult to manage infections. Researchers have started developing antibiotic-free treatment alternatives order decrease the risk of resistant microbial strain selection for efficient management antibiotic tolerant biofilm The present study reports fabrication characterization magnetite-based nanostructured coatings biofilm-resistant surfaces. Specifically, magnetite...
The present paper aims atincreasing the bioperformance of implantable Ti50Zr alloy using zwitterionic cysteine drug coating. Aspects such as stability, biocompatibility, and antibacterial effects were investigated with help various methods infrared spectroscopy (FT-IR), scanning electronic microscopy (SEM), electrochemical methods, contact angle determinations cell response. experimental data coating indicate existence a hydration layer due to hydrophilic groups evidenced in FT-IR which is...
Dextran coated cerium doped hydroxyapatite (Ca10-xCex(PO4)6(OH)2), with x = 0.05 (5CeHAp-D) and 0.1 (10CeHAp-D) were deposited on Si substrates by radio frequency magnetron sputtering technique for the first time. The morphology, composition, structure of resulting coatings examined scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDX), atomic force (AFM), metallographic (MM), Fourier transform infrared (FTIR), glow discharge optical emission (GDOES), respectively....
Graphene is widely used in nanotechnologies to amplify the photocatalytic activity of TiO2, but development TiO2/graphene composites imposes assessment their risk human and environmental health. Therefore, reduced graphene oxide was decorated with two types TiO2 particles co-doped 1% iron nitrogen, one them being obtained by a simultaneous precipitation Ti3+ Fe3+ ions achieve uniform distribution, other after sequential these cations for higher concentration on surface. Physico-chemical...
The primary focus of the paper is fabrication nanotubes via a two steps anodizing procedure on TiZr substrate followed subsequent annealing treatments and their effect surface biocompatibility. step process optimized for obtaining uniform ordered nanotubular structures, that are then annealed in air or reduced an Ar/H2 environment. high aspect ratio structures (diameter 160 nm, length 9.4 μm) maintained morphology after reduction. While thermal burned-off fluoride, they converted tubes to...
TiO 2 nanowires are fabricated by electrospinning on Ti50Zr alloy, changing the elaboration conditions. The surface covered with is characterized performing scanning electronic microscopy and contact angle measurements. best from point of view organization chosen based experimental electrochemical stability tested in Fusayama saliva. response HGF‐1 gingival fibroblasts cells established discussed. Cellular evaluated cell viability, lactate dehydrogenase test, nitric oxide level interleukines...
The advancement of nanotechnology in the last decade has developed an abundance novel and intriguing TiO2-based nanomaterials that are widely used many sectors, including industry (as a food additive colorant cosmetics, paints, plastics, toothpaste) biomedicine (photoelectrochemical biosensing, implant coatings, drug delivery, new emerging antimicrobial agents). Therefore, increased use engineered raised serious concern about human exposure their unexpected cytotoxic effects. Since...
Fish are able to accumulate by ingestion various contaminants of aquatic environment, with negative consequences on their intestine, being continuously threatened worldwide heavy metals, pesticides and antibiotics resulted from the human activities. Consequently, health other species can be affected eating contaminated fish meat. In this context, our study aimed perform a comparison between changes in intestine samples Carassius gibelio individuals collected different artificial lakes...
The paper studies the electrochemical stability in physiological serum and cell response of nanostrucures obtained on Zr by anodizing electrolytes containing fluorinated ethylene glycol various amounts K 2 CO 3 . SEM analysis revealed that porous nanostructure formation is greatly influenced concentrations electrolyte tipping balance between oxide dissolution during process. porosities samples were evaluated from polarization resistances recorded serum. Chronoamperometric measurements...
Over the past decades, nanotechnology has increasingly developed and reached to monopolize almost all of human activity areas.Materials with nanoscaled dimensions are not only for technological or medical purposes, but also, they can be found in daily commercial products.So, nanoparticles' applications a welldefined place our modern life.Almost 70% global pigment production is based on titanium dioxide (TiO 2 ), which represents also one top five nanoparticles used consumer products.TiO...