A5082064190- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Ion Channels and Receptors
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Neuroscience and Neural Engineering
- Biochemical effects in animals
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Adenosine and Purinergic Signaling
- Plant Stress Responses and Tolerance
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neurobiology and Insect Physiology Research
- Advanced Sensor and Energy Harvesting Materials
- Nicotinic Acetylcholine Receptors Study
- Dermatology and Skin Diseases
- S100 Proteins and Annexins
- Exercise and Physiological Responses
- COVID-19 diagnosis using AI
- Neuroscience of respiration and sleep
- Angiogenesis and VEGF in Cancer
- Vagus Nerve Stimulation Research
- Lymphadenopathy Diagnosis and Analysis
University of Bucharest
2013-2024
The Graduate University for Advanced Studies, SOKENDAI
2011
The capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1), acts as a polymodal detector of pain-producing chemical and physical stimuli in sensory neurons. Hyperglycemia hypoxia are two main phenomena diabetes associated with several complications. Although many studies on streptozotocin-induced diabetic rats indicate that early neuropathy is potentiation TRPV1 activity dorsal root ganglion neurons, its underlying mechanism distinctive roles hyperglycemia have not been...
Resident macrophages from dorsal root ganglia are important for the development of traumatic-induced neuropathic pain. In first 5-7 days after a traumatic sciatic nerve injury (i.e., spinal ligation (SNL), spared (SNI), transection or and transection), Ionized binding adapter protein 1 (Iba1) (+) resident cluster around neurons, possibly contributing to injury-induced hypersensitivity. Since infiltrating gradually recruited lesion site peak at about 7 days, few post-lesion offer window...
Abstract Aim In this study, we aimed: (i) to obtain and functionally characterize the cultures of late endothelial progenitor cells ( EPC s) from animal blood; (ii) investigate potential beneficial effects circulating microparticles MP healthy origins on dysfunctionality in atherosclerosis as well involved mechanisms. Methods Late s were obtained expanded culture peripheral blood isolated two groups: hypertensive–hyperlipidaemic HH ) control (C) hamsters. parallel experiments, incubated with...
Abstract Spinal microglia change their phenotype and proliferate after nerve injury, contributing to neuropathic pain. For the first time, we have characterized electrophysiological properties of potential role microglial potassium channels in spared injury (SNI) model We observed a strong increase inward currents restricted at 2 days associated with hyperpolarization resting membrane (RMP) cells compared later time‐points naive animals. identified pharmacologically genetically current as...
(1) Background: As membrane channels contribute to different cell functions, understanding the underlying mechanisms becomes extremely important. A large number of neuronal have been investigated, however, less studied are expressed in glia population, particularly microglia. In present study, we focused on function Kv1.3, Kv1.5 and Kir2.1 potassium both BV2 cells primary microglia cultures, which may impact cellular migration process. (2) Methods: Using an immunocytochemical approach, were...
Transient receptor potential melastatin 8 (TRPM8), a membrane ion channel, is activated by thermal and chemical stimuli. In pancreatic ductal adenocarcinoma, TRPM8 required for cell migration, proliferation, senescence associated with tumor size adenocarcinoma stages. Although the underlying mechanisms of these processes have yet to be described, this cation-permeable channel has been proposed as an oncological target. study, glycosylation status was shown affect calcium uptake. expressed in...
This article presents experimental measurements performed in order to connect a neuronal cell culture an exoprosthesis. The experiments focused on the biosignals� acquisition from culture. A special gold-plated glass plate device was realized and several constructive variants were analyzed. Olympus microscope with fluorescence photo system used. of bio signals neuron is described paper. made sterile environment within laboratory Institute Cellular Biology Pathology. have been for pair...
The functioning of microglial cells inside the central nervous system depends on their ion channels expression. Microglia are capable synthesizing different cytokines and chemokines, including CXCL1, responding to action via specific receptors. In this study, we explore effect intrathecal injection CXCL1 potassium currents, expressed in CX3CR1-Green Fluorescent Protein labeled microglia transgenic mice. results showed that hyperpolarized by enhancing inward rectifying currents increasing...
The natural differences between human-made electronics and biological tissues constitute a huge challenge in materials the manufacturing of next-generation bioelectronics. As such, we performed series consecutive experiments for testing biofunctionality biocompatibility device implantation, by changing exterior chemical physical properties coating it with silicone or hydrogels. In this article, present comparison main characteristics an electronic coated either hydrogel (GelMa). was...
Voltage-gated sodium channels are critical for the initiation and propagation of action potentials regulation neuronal excitability. Hyperglycemia hypoxia two main changes in diabetes frequently associated with several complications. Although many studies on streptozotocin-induced diabetic rats indicate that early neuropathy is increased amplitude faster kinetics channels, distinctive roles high glucose have not been completely clarified. Here we show hypoxic conditions (overnight exposure)...
Cytokine proteins are involved in different signaling pathways throughout the central nervous system. To study efficacy of an inflammatory cytokine, macrophage migration inhibitory factor (MIF), which acts via several receptor molecules including CXCR2, male rats’ behaviors were determined after intracerebroventricular (ICV) administration MIF. There three treatments: One group received only a second MIF and CXCR2 antagonist (SB265610), third, control carrier medium saline. All rats...
CXCL1 and CXCL2 are homologous chemokines that can be upregulated in different pathological conditions, affecting among other targets, neuronal ionic channels or receptors. TRPV1 is a polymodal nociceptor expressed both dorsal root trigeminal ganglia neurons. According to existing data, short-term incubation with reduce desensitization, however, the long-term modulatory effect of on this receptor less known. In present study we investigated influence overnight 1.5 nM functioning receptors...
Background: To fill the knowledge gap regarding antiviral immunity in oncologic patients, we performed a comparative study on natural/vaccine-induced SARS-CoV-2 head and neck cancer (HNC) Romania. Methods: Blood was collected from HNC (n=49) controls (n=14), stratified as vaccinated (RNA/adenovirus-based vaccines), convalescent, hybrid immunity. Plasma IgG/IgA antibodies (Abs) against Spike (S1/S2), receptor binding domain (RBD), nucleocapsid (NC), cytokines were quantified using MILLIPLEX;...
Abstract Background and Aims Colony‐stimulating factor 1 (CSF1) is a growth secreted by dorsal root ganglia (DRG) neurons important for DRG macrophages spinal cord (SC) microglia injury‐induced proliferation activation, specifically released after spared nerve injury (SNI). In this study, we investigated if SNI‐induced CSF1 expression perineuronal rings of around mouse vary between L3‐L5 with the neuronal type, + projections at SC horns were associated an increased microglial number in...
Abstract The response of dorsal root ganglion (DRG) neurons to metabolic inhibition is known involve calcium‐activated K + channels; in most neuronal types ATP‐sensitive channels (K ATP ) also contribute, but this not yet established the DRG. We have investigated presence a current using whole‐cell recordings from rat DRG neurons, classifying functionally by their “current signature” (Petruska et al, J Neurophysiol 84: 2365–2379, 2000). clearly identified only 1 out 62 probably nociceptor....
Novel research results of an ongoing development a personalized forearm neuroprosthesis are being presented. A complete design process shows how the mechanical structure is developed from 3D scanning to printing. With individual DC motor for each finger and one palm, achieves 15 degrees freedom. Artificial skin cover fingers acting as resistive pressure sensors, giving linear full range readout voltage proportional applied pressure. Fabrication steps first-generation implantable electrodes...