A5019566792- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Occupational and environmental lung diseases
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Pharmacological Effects of Natural Compounds
- Ion channel regulation and function
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Cellular Mechanics and Interactions
- Vascular Tumors and Angiosarcomas
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Peripheral Neuropathies and Disorders
University of Lausanne
2016-2024
The immune system is involved in the development of neuropathic pain. In particular, infiltration T-lymphocytes into spinal cord following peripheral nerve injury has been described as a contributor to sensory hypersensitivity. We used spared (SNI) model pain Sprague Dawley adult male rats assess proliferation, and/or protein/gene expression levels for microglia (Iba1), (CD2) and cytotoxic (CD8). dorsal horn ipsilateral SNI, Iba1 BrdU stainings revealed microglial reactivity respectively,...
Abstract Spinal microglia change their phenotype and proliferate after nerve injury, contributing to neuropathic pain. For the first time, we have characterized electrophysiological properties of potential role microglial potassium channels in spared injury (SNI) model We observed a strong increase inward currents restricted at 2 days associated with hyperpolarization resting membrane (RMP) cells compared later time‐points naive animals. identified pharmacologically genetically current as...
(1) Background: As membrane channels contribute to different cell functions, understanding the underlying mechanisms becomes extremely important. A large number of neuronal have been investigated, however, less studied are expressed in glia population, particularly microglia. In present study, we focused on function Kv1.3, Kv1.5 and Kir2.1 potassium both BV2 cells primary microglia cultures, which may impact cellular migration process. (2) Methods: Using an immunocytochemical approach, were...
ObjectiveMalignant pleural mesothelioma is a fatal disease and clinical challenge, as few effective treatment modalities are available. Previous evidence links the gut microbiome to host immunoreactivity tumors. We thus evaluated impact of novel modulator compound (MMC) on microbiota composition, tumor immune microenvironment, cancer control in model malignant mesothelioma.MethodsAge- weight-matched immunocompetent (n = 23) or athymic BALB/c mice 15) were randomly assigned MMC no (control)...
Abstract Objective Malignant pleural mesothelioma (MPM) is a deadly disease with limited treatment options. Recently, dual immune checkpoint inhibition therapy (ICI) showed improved patient survival. However, only fraction of patients were responsive to immunotherapy. One potential mechanism MPM resistance ICIs could be their endothelial anergy that hampers leukocyte trafficking the tumor bulk. Here, we hypothesized vascular-targeted low dose photodynamic (L-PDT), relieve and improve...
Abstract Objective Immune checkpoint inhibition (ICI) therapy has revolutionized the outcome of certain cancers such as malignant pleural mesothelioma (MPM). However, patient responsiveness to this treatment remains unpredictable. Recently, a role for gut microbiota composition emerged patients generate robust immune response against their tumors, following immunotherapy. Here, we studied impact Prembion®, pre-biotic and modulator microbiota, on tumor control lymphocyte infiltration in...
Abstract Objective Malignant pleural mesothelioma (MPM) is a deadly disease with dismal prognosis. Prior studies combining surgery intrapleural hyperthermic chemotherapy (IPHC) have shown improved survivals in selected patients MPM. However, the mechanisms by which IPHC acts on MPM and its microenvironment remains unknown. Here we focus tumor endothelial adhesion molecule expression patterns. Methods First, determined impact of vascular compartments vitro using novel bioincubater for cell...