A5068464851- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemistry and Bioactivity Studies
- Natural Compounds in Disease Treatment
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Bioactive Natural Diterpenoids Research
- Bioactive Compounds and Antitumor Agents
- Hormonal and reproductive studies
- Mesenchymal stem cell research
- Exercise and Physiological Responses
- Signaling Pathways in Disease
- Cell Adhesion Molecules Research
- Axon Guidance and Neuronal Signaling
- Pharmacological Effects of Natural Compounds
- Graphene and Nanomaterials Applications
- Histone Deacetylase Inhibitors Research
- Spinal Cord Injury Research
- Nanoparticle-Based Drug Delivery
- Electrochemical sensors and biosensors
- Extracellular vesicles in disease
- Sirtuins and Resveratrol in Medicine
- Cholinesterase and Neurodegenerative Diseases
- Cellular Mechanics and Interactions
Nantong University
2020-2024
Affiliated Hospital of Nantong University
2022-2023
Soochow University
2023
University of Cincinnati Medical Center
2019-2020
University of Cincinnati
2020
Glioblastoma (GBM) is one of the most challenging malignant brain tumors to treat. Herein, we describe a nanoenzyme hemostatic matrix strategy with tumor cavity in situ application that simultaneously serves as photothermal agent and induces immunogenic cell death after GBM surgical resection enhance antitumor immunity delay recurrence. The system (Surgiflo@PCN) contains Surgiflo, multispace structure can be used penetrate different shapes cavities prevent postoperative hemorrhage. As well,...
Abstract Chronic pain has attracted wide interest because it is a major obstacle affecting the quality of life. Consequently, safe, efficient, and low‐addictive drugs are highly desirable. Nanoparticles (NPs) with robust anti‐oxidative stress anti‐inflammatory properties possess therapeutic possibilities for inflammatory pain. Herein, bioactive zeolitic imidazolate framework (ZIF)‐8‐capped superoxide dismutase (SOD) Fe 3 O 4 NPs (SOD&Fe @ZIF‐8, SFZ) developed to achieve enhanced...
BackgroundTherapies are urgently required to ameliorate pathological cardiac hypertrophy and enhance function in heart failure. Our preliminary experiments have demonstrated that exogenous NADPH exhibits a positive inotropic effect on isolated heart. This study aims investigate the effects of failure, as well underlying mechanisms involved.MethodsEndogenous plasma contents were determined patients with chronic failure control adults. The investigated toad or rat isoproterenol (ISO)–induced...
Paclitaxel is a widely used and potent chemotherapeutic agent for the treatment of cancer. However, patients receiving paclitaxel often develop an acute pain syndrome which there are few options. Astrocytes play important role in pathogenesis multiple preclinical models, as well paclitaxel-treated rodents. it still unclear what exact contribution astrocytes may be paclitaxel-associated (P-APS).P-APS was modeled by single systemic or intrathecal injection astrocyte tested immunohistochemical,...
Histone lysine crotonylation (KCR), a novel epigenetic modification, is important in regulating broad spectrum of biological processes and various diseases. However, whether KCR involved neuropathic pain remains to be elucidated. We found occurs macrophages, sensory neurons, satellite glial cells trigeminal ganglia (TG), astrocytes, microglia the medulla oblongata. TG was detected mainly small medium lesser extent large neurons. Peripheral nerve injury elevated levels macrophages dorsal root...
Abstract Aims The current evidence demonstrates that mesenchymal stem cells (MSCs) hold therapeutic potential for ischemic stroke. However, it remains unclear how changes in the secretion of MSC cytokines following overexpression heme oxygenase‐1 (HO‐1) impact excessive inflammatory activation a mouse stroke model. This study investigated this aspect and provided further insights. Methods middle cerebral artery occlusion (MCAO) model was established, subsequent injections MSC, HO‐1 , or PBS...
Abstract Spinal microglia change their phenotype and proliferate after nerve injury, contributing to neuropathic pain. For the first time, we have characterized electrophysiological properties of potential role microglial potassium channels in spared injury (SNI) model We observed a strong increase inward currents restricted at 2 days associated with hyperpolarization resting membrane (RMP) cells compared later time‐points naive animals. identified pharmacologically genetically current as...
Neuropathic pain is a debilitating chronic condition that lacks effective treatment. The role of cytokine- and chemokine-mediated neuroinflammation in its pathogenesis has been well documented. Follistatin (FST) secreted protein known to antagonize the biological activity cytokines transforming growth factor–β (TGF-β) superfamily. involvement FST neuropathic underlying mechanism remain largely unknown. Here, we report was up-regulated A-fiber sensory neurons after spinal nerve ligation (SNL)...
Currently, medical treatment of inflammatory pain is limited by a lack safe and effective therapies. Triptonide (TPN), major component Tripterygium wilfordii Hook.f. with low toxicity, has been shown to have good anti-inflammatory neuroprotective effects. The present study aims investigate the effects TPN on chronic pain.Inflammatory was induced intraplantar injection complete Freund's adjuvant (CFA). TPN's three different doses were intravenously administered compare analgesic efficacy: 0.1...
Glioblastoma multiforme (GBM) is among the most challenging malignant brain tumors, making development of new treatment strategies highly necessary. Glioma stem cells (GSCs) markedly contribute to drug resistance, radiation and tumor recurrence in GBM. The therapeutic potential nanomaterials targeting GSCs GBM urgently needs be explored. A magnetic-responsive biomimetic nanosystem (FDPM), coated with glioma cell membranes (CMs), was designed for targeted eradication as well their associated...
Abstract Background: Triptonide (TPN) is a major component of Tripterygium wilfordii Hook.f., and reportedly has anti-inflammatory neuroprotective effects. Recent studies have demonstrated that the phosphatidylinositol 3-kinase (PI3K)/AKT pathway plays an important role in pathogenesis inflammatory pain. Here we investigated anti-nociceptive effect systemic treatment with TPN on mouse models chronic pain explored possible mechanisms. Results: Unilateral hind paw injection complete Freund’s...