A5073829669- Animal Virus Infections Studies
- Pain Mechanisms and Treatments
- Virus-based gene therapy research
- Anesthesia and Pain Management
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Nausea and vomiting management
- Pain Management and Opioid Use
- Dermatology and Skin Diseases
- Pediatric Pain Management Techniques
- Caveolin-1 and cellular processes
- Neuropeptides and Animal Physiology
- Exercise and Physiological Responses
- Mosquito-borne diseases and control
- Tryptophan and brain disorders
- Ion channel regulation and function
- Animal Disease Management and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Cancer, Stress, Anesthesia, and Immune Response
- Influenza Virus Research Studies
- Histone Deacetylase Inhibitors Research
- Probiotics and Fermented Foods
- Hormonal and reproductive studies
- Inflammatory Biomarkers in Disease Prognosis
Affiliated Hospital of Nantong University
2012-2025
Nantong University
2012-2025
Guangxi Veterinary Research Institute
2015-2024
Guangxi University
2024
Harbin Veterinary Research Institute
2022
Chinese Academy of Agricultural Sciences
2022
The Ohio State University
2017
Abstact Direct induction of macrophage ramification has been shown to promote an alternative (M2) polarization, suggesting that the ramified morphology may determine function immune cells. The ketone body metabolite β‐hydroxybutyrate (BHB) elevated in conditions including fasting and low‐carbohydrate ketogenic diet (KD) can reduce neuroinflammation. However, how exactly BHB impacts microglia remains unclear. We report as well its producing stimuli KD induced obvious ramifications murine...
ABSTRACT We previously isolated a porcine epidemic diarrhea virus (PEDV) strain, PC177, by blind serial passaging of the intestinal contents diarrheic piglet in Vero cell culture. Compared with highly virulent U.S. PEDV strain PC21A, tissue culture-adapted PC177 (TC-PC177) contains 197-amino-acid (aa) deletion N-terminal domain spike (S) protein. orally inoculated neonatal, conventional suckling piglets TC-PC177 or PC21A to compare their pathogenicities. Within 7 days postinoculation, caused...
Z-guggulsterone, an active compound extracted from the gum resin of tree Commiphora mukul, has been shown to improve animal memory deficits via activating brain-derived neurotrophic factor signaling pathway. Here, we investigated antidepressant-like effect Z-guggulsterone in a chronic unpredictable stress mouse model depression. The effects were assessed mice with tail suspension test and forced swimming test. was also depression fluoxetine as positive control. Changes hippocampal...
Influenza A viruses (IAVs) pose a persistent potential threat to human health because of the spillover from avian and swine infections. Extensive surveillance was performed in 12 cities Guangxi, China, during 2018 2023. total 2540 samples (including 2353 nasal swabs 187 lung tissues) were collected 18 pig farms with outbreaks respiratory disease. From these, 192 IAV-positive 19 genomic sequences obtained. We found that H1 H3 influenza (swIAVs) multiple lineages genotypes have continued...
Newcastle disease is an important poultry that also affects Columbiform birds. The viruses adapted to pigeons and doves are referred as pigeon paramyxoviruses 1 (PPMV-1). PPMV-1 frequently isolated from worldwide have the potential cause in chickens. complete genomes of 18 China during 2012–2018 were sequenced by next-generation sequencing (NGS). Comprehensive phylogenetic analyses showed five belong sub-genotype VI1.2.1.1.2.1 13 isolates VI.2.1.1.2.2. results demonstrate these sub-genotypes...
Coinfection caused by various genotypes of porcine epidemic diarrhea virus (PEDV) is a new disease situation. We previously reported the coexistence PEDV strains containing different ORF3 in China. In this study, 17GXCZ-1ORF3d and 17GXCZ-1ORF3c were isolated plaque-purified from same piglet, which had natural large deletion at 172-554 bp position gene or possessed complete gene, respectively. Meanwhile, >99% nt identity with 5'UTR, ORF1a/1b, S, E, M, N 3'UTR regions but only demonstrated low...
Abstract Background We aimed to determine whether systemic immune-inflammation index (SII) combined with prealbumin can provide better predictive power for postoperative pneumonia in patients undergoing lung resection surgery. Methods identified eligible surgery at the Affiliated Hospital of Nantong University from March 2021 2022. Demographic characteristics, clinical data, and laboratory information were collected reviewed electronic medical records patients. To test effect detection SII...
Depression is a neurological disorder characterized by persistent low mood. A number of studies have suggested that the use type 1 cannabinoid receptor (CB1R) agonists can reduce depressive behavior, but its effect on behavior and nerve damage rats exposed to chronic unpredictable mild stress (CUMS) has not been reported.Rats were CUMS for 4 weeks induce behavior. Male Sprague-Dawley (SD) aged 6-8 randomly divided into six groups: control group (control), depression (CUMS), + fluoxetine...
Neuropathic pain is a debilitating chronic condition that lacks effective treatment. The role of cytokine- and chemokine-mediated neuroinflammation in its pathogenesis has been well documented. Follistatin (FST) secreted protein known to antagonize the biological activity cytokines transforming growth factor–β (TGF-β) superfamily. involvement FST neuropathic underlying mechanism remain largely unknown. Here, we report was up-regulated A-fiber sensory neurons after spinal nerve ligation (SNL)...
Chronic postsurgical pain (CPSP) is a chronic state that difficult to be treated clinically. A series of complicated changes have been produced from nociceptive stimulation the occurrence and development pain. Many mechanisms remain unclear. In order study role intercellular gap junctions in inducing inflammatory microenvironment at beginning nociceptor after operation, model skin/muscle incision retraction (SMIR) was established. We observed expression exchange proteins directly activated...
Chronic postsurgical pain (CPSP) has a high incidence, but the underlying mechanism is not well understood. Accumulating evidence suggested that central sensitization main of pain. To study role p120 in CPSP, skin/muscle incision and retraction (SMIR) model was established, immunofluorescence staining western blotting were performed to analyze expression spinal cord dorsal root ganglion (DRG). The results demonstrated SMIR increased DRG compared with naive group. Furthermore, it mainly...
Farmers involved in the lucrative pork trading business between China and Southeast Asian countries should be aware of a recently discovered novel porcine deltacoronavirus (PDCoV) Guangxi province, China. A PDCoV strain, CHN/GX/1468B/2017, was isolated from small intestinal contents piglets with diarrhea this region, titer 1 × 10 8.0 TCID 50 /mL on LLC-PK cells. The full-length genome sequence consists 25,399 nt as determined by next-generation sequencing deposited GenBank (accession number...
We report here the complete genomic sequence of Japanese encephalitis virus (JEV) strain FC792, isolated from aborted fetuses sows which were unimmunized with JEV vaccines in Guangxi Province, southern China. The genome FC792 had highest nucleotide homology (99.7%) and amino acid identity (99.4%) SA14-14-2 (GenBank accession number AF315119). Phylogenetic analysis showed that closest phylogenetic relationship to YUNNAN0901 JQ086762). This study will help us understand molecular pathogenesis...
Caveolae (CAV) are an invaginated microcapsule with the shape of Ω on surface cell membrane. Caveolin-1 (CAV-1) is involved in neuropathic pain, and adenosine monophosphate (AMP)-exchange protein directly activated by cAMP1 (EPAC-1) a potential therapeutic target for chronic pain. However, whether EPAC-1 promotes postsurgical pain (CPSP) through CAV-1 has not been reported. Here, we aim to investigate underlying mechanism CAV CPSP.All rats were divided into 9 groups, including Naive group,...
ABSTRACT We report here the complete genomic sequence of porcine parvovirus (PPV) N strain, isolated in 1989 from viscera a stillborn fetus farrowed by gilt Guangxi, southern China. Phylogenetic analyses suggest that PPV-N strain is closely related to attenuated PPV NADL-2 strains. The has good immunogenicity, genetic stability, and safety.
Porcine circovirus type 3 (PCV3) was first described in 2016 U.S. swine herds as a pathogenic agent for pigs. To date, PCV3 has been reported to be widely circulating the United States, China, South Korea, Brazil, Italy, and Poland. Here, we report genome sequence of strain (CH/GX/1776D/2017) isolated from Guangxi Province southern China. The data presented this study will help us better understand molecular characteristics genetic diversity
Postoperative delirium (POD) is a serious complication in elderly patients after major surgery, associated with high morbidity and mortality. Treatment prevention methods are limited. Repetitive transcranial magnetic stimulation (rTMS) shows potential enhancing cognitive function improving consciousness. To evaluate whether early postoperative rTMS has protective effect against POD to explore its mechanisms. Patients aged 60 years or older, scheduled for abdominal were randomly assigned...
Butorphanol is a synthetic selective opioid receptor antagonist that exhibits substantial analgesic effects. The present study aimed to explore the effects of butorphanol on neurodegenerative disease cell model and investigate its specific regulatory mechanism. Cell viability PC12 cells was assessed using Counting Kit‑8 assay. Oxidative stress levels were measured by corresponding kits western blotting protein markers. Apoptosis determined terminal‑deoxynucleoitidyl transferase mediated nick...