A5100396035- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Tryptophan and brain disorders
- Esophageal Cancer Research and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Genomics and Diagnostics
- Diverticular Disease and Complications
- Cancer Cells and Metastasis
- Neuroendocrine Tumor Research Advances
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects of Medicinal Plants
- Bone Metabolism and Diseases
- Pancreatic function and diabetes
- Cancer, Stress, Anesthesia, and Immune Response
- Neutropenia and Cancer Infections
- Gastrointestinal Tumor Research and Treatment
- Single-cell and spatial transcriptomics
- Metastasis and carcinoma case studies
Nantong University
2016-2025
Wuxi No.2 People's Hospital
2025
Hebei North University
2023-2024
Weifang People's Hospital
2023
Bioscience (China)
2023
Taizhou People's Hospital
2018-2022
Qilu Hospital of Shandong University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2019
Sichuan Agricultural University
2019
Affiliated Hospital of Nantong University
2017-2018
Abstact Direct induction of macrophage ramification has been shown to promote an alternative (M2) polarization, suggesting that the ramified morphology may determine function immune cells. The ketone body metabolite β‐hydroxybutyrate (BHB) elevated in conditions including fasting and low‐carbohydrate ketogenic diet (KD) can reduce neuroinflammation. However, how exactly BHB impacts microglia remains unclear. We report as well its producing stimuli KD induced obvious ramifications murine...
Depression is a common psychiatric disorder with heavy economic and social burdens. Searching new agents better antidepressant-like activities of great significance for depression therapy. Tauroursodeoxycholic acid (TUDCA), clinical drug gallstone treatment, possesses neuroprotective effects in different brain disorders. However, whether it affects remains unclear. We addressed this issue by evaluating the effect TUDCA on induced chronic unpredictable stress (CUS). Results showed that...
Z-guggulsterone, an active compound extracted from the gum resin of tree Commiphora mukul, has been shown to improve animal memory deficits via activating brain-derived neurotrophic factor signaling pathway. Here, we investigated antidepressant-like effect Z-guggulsterone in a chronic unpredictable stress mouse model depression. The effects were assessed mice with tail suspension test and forced swimming test. was also depression fluoxetine as positive control. Changes hippocampal...
For esophageal cancer patients with a clinical complete response (cCR) after standard-dose radiotherapy concurrent chemotherapy, data on the survival outcomes and recurrence patterns remain scarce. To evaluate impact of dose escalation overall for this subset patients, we carried out current investigation.Medical records 80 cCR chemotherapy at our center from 2010 to 2014 were allocated into group (50.4 Gy, observation group) or radiation dose-escalation (59.4 control group). In cohort...
Cholestasis of pregnancy endangers fetal and neonatal survival, yet systematic knowledge the cause effect disrupted bile acid (BA) homeostasis in is limited. Here we show that gestation stage-associated BA dysregulation swine correlated with death resulting from compromised capacity for secretion increased alternative systemic efflux. The balance input output developing uterus suggested little uptake metabolism maternal by placenta-fetus unit, implying a protection role placenta preventing...
// Yang Chen 1, * , Weishuai Liu 2, Peng Wang 3 Hailing Hou 1 Ningbo Linlin Gong Youyou Kai Ji 2 Lujun Zhao Ping Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center Cancer, Key Laboratory Prevention Therapy, 300060, China Pain Management, Research, Peking International Beijing 102206, These authors have contributed equally to this work Correspondence to: Zhao, email: zhaolujun@tjmuch.com Keywords:...
Abstract Background and objective Intra-corporeal delta-shaped anastomosis (IDA) is an important development in laparoscopic digestive-tract reconstruction. We applied it right hemicolectomy for colon cancer compared the short-term outcomes between patients treated with IDA conventional extracorporeal (EA). Methods Between 1 January 2016 October 2017, 36 50 who underwent EA, respectively, were included. Data on clinicopathological characteristics, surgical outcomes, post-operative recovery...
To investigate whether the response to induction chemotherapy (IC) would impact timing of thoracic radiotherapy (TRT) in limited-stage small-cell lung cancer (LS-SCLC).A total 146 patients with LS-SCLC who had received two six cycles IC followed by TRT from January 2009 December 2011 at our hospital were included this study. Patients divided into groups based on time was administered: early (administered after 2-3 chemotherapy) or late 4-6 cycles). Overall survival (OS) and progression-free...
This study was aimed at exploring the mechanism of serine threonine protein kinase 11 (STK11)/Adenosine 5 ′ ‐monophosphate‐activated (AMPK) signaling pathway after immunotherapy for esophageal squamous cell carcinoma (ESCC), providing basic information clinical treatment ESCC. In this study, tissue specimens from 100 patients with ESCC who underwent surgical in Taizhou People’s Hospital (group A) and 20 recurrent or metastatic received second‐line B) were collected. The real‐time fluorescent...
<title>Abstract</title> Colorectal cancer is among the most common malignant tumors globally, and distinct treatment requirements for colon rectal cancers underscore necessity to identify specific molecules each type. Although EIF4A1 plays a crucial role in translational initiation, its therapeutic potential remains unclear. This study utilized TCGA database reveal that expression upregulated both types associated with poorer survival outcomes. KEGG GO analyses indicate primarily...
<title>Abstract</title> The aim of this study was to investigate the relationship between fibroblast growth factor 19 (FGF19) and prognosis immune infiltration colorectal cancer (CRC), find related genes pathways affecting occurrence development CRC, providing an important molecular basis for early diagnosis immunotherapy CRC. We performed Venn overlap analysis on prognosis-related CRC up-regulated differentially expressed (DEGs) immune-related gene sets obtain final DEGs. investigated...
e15567 Background: Both regorafenib and TAS-102 have shown significant, but limited survival benefits for metastatic colorectal cancer (mCRC) patients who progressed after standard treatments. Due to their unique mechanisms of action non-overlapping toxicities, a preliminary phase I study (REMETY) has demonstrated that combined with in four-week schedule was feasible safe, at the cost recommended II dose being 25 mg/m 2 BD. This aimed evaluate efficacy safety biweekly plus refractory mCRC....
We detected PD-L1 and intra-tumoral CD8+ T lymphocytes (CD8+ TIL) in 19 patients with esophageal carcinosarcoma (ECS). The median follow-up period of these was 43 months, the three- five-year survival rates were 78.9 63.2%, respectively. No statistically significant correlation observed between TIL sarcomatous components(SC) (r = -0.262, p 0.279) epithelial carcinomatous (EC) 0.055, 0.824). This study examined immunological markers ECS for first time. is highly expressed SC associated a...
Lung squamous cell cancer (SCC) and accounts for approximately 20%-30% of all lung cancers. Surgery, chemotherapy radiotherapy are the main treatments SCC patients. A case with patient who was treated using iodine 125 seeds (I-125) because location tumor adjacent to great vessels. I-125 is an ideal brachytherapy patients large masses lost chance operation. adjuvant therapy, combined molecular targeting therapy might serve improve prognosis
Advanced non-small-cell lung cancer (NSCLC) patients with EGFR exon 19 deletion often get benefits from the treatment of tyrosine kinase inhibitors (TKI). In same way, NSCLC mesenchymal-to-epithelial transition (MET) amplification crizotinib. The becomes extremely difficult for both and MET amplification, after failure first-line TKI. An advanced patient was treated However, disease recurred four months. found biopsy again. combination crizotinib, while eight by pembrolizumab pemetrexed +...
Cancer of unknown primary (CUP) is metastatic at diagnosis with an site, indicating a high degree malignancy poor prognosis. The development and application targeted therapy immunotherapy are current research hotspots, which provide additional treatment options for CUP.A 36-year-old male presented pain on the right hip in April 2018. After various examinations, he was diagnosed CUP. This patient received chemotherapy, immunotherapy, local radiotherapy our department. However, use after...
Objective We aimed to investigate whether the standard approach of concurrent chemotherapy and radiation is an appropriate choice for elderly patients with limited-stage small-cell lung cancer ( LS-SCLC). Methods A total 168 LS-SCLC who had received thoracic radiotherapy from January 2006 December 2011 at our institution were included in this retrospective study. Patients aged 65 years or older defined as elder, we compare chemoradiotherapy CCRT) sequential SCRT) group (53 patients)...