A5055911803- Ferroptosis and cancer prognosis
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Electrospun Nanofibers in Biomedical Applications
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Advancements in Battery Materials
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
- Urologic and reproductive health conditions
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Fibroblast Growth Factor Research
- Urinary and Genital Oncology Studies
- vaccines and immunoinformatics approaches
- Kruppel-like factors research
- Immune cells in cancer
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Pediatric Urology and Nephrology Studies
- Mesenchymal stem cell research
Jiangsu University of Science and Technology
2024-2025
Anhui University of Traditional Chinese Medicine
2024-2025
Peking University
2019-2024
Peking University First Hospital
2019-2024
Hebei North University
2024
Hebei Medical University
2023
Third Hospital of Hebei Medical University
2023
Yangzhou University
2022
Beijing Chest Hospital
2021
ORCID
2021
To deal with the low conductivity and structural instability of silicon (Si)-based anode, a Ge–Si/C nanofiber (Ge–Si/CNF) composite is fabricated based on different starting reaction potentials for Si Ge lithium excellent Ge. Sucrose innovatively introduced as spinning aid to maintain carbon fiber structure derived from poly(vinyl alcohol) polymer. When Ge–Si/CNFs are investigated anode material lithium-ion batteries, it demonstrates cyclic stability rate capability. Specifically, can still...
Chronic heart failure (CHF) is a complex cardiovascular disease caused by different pathological mechanisms. Modern medicine has made advancements in CHF treatment; however, there are still many challenges. Ershen Zhenwu Decoction (ESZWD) Xin'an that been clinically applied for years and had good efficacy against CHF; its underlying mechanisms remain undetermined. Therefore, this study aims to investigate the primary molecular of ESZWD treatment elucidate multi-target multi-level mode...
Prolyl 4-hydroxylase, beta polypeptide (P4HB) protein has been found to be associated with tumorigenesis in many types of tumor, However, the relationship between P4HB and clear cell renal carcinoma (ccRCC) not clarified. In this study, we focus on correlation expression ccRCC. Through Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) our database immunohistochemical (IHC) staining. Compared adjacent normal tissues, both mRNA levels ccRCC tissues were enhanced. The...
In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared. Bacterial cellulose (BC) physically chemically modified by laser hole forming selective oxidation to obtain the (DMBC). The soybean (SPI) compounded on DMBC DMBC/SPI better biocompatibility. used repair damaged urethra in rabbits. results showed that beneficial heal did...
Urethral stricture and reconstruction are one of the thorny difficult problems in field urology. The continuous development tissue engineering biomaterials has given new therapeutic thinking to this problem. Bacterial cellulose (BC) is an excellent biomaterial due its accessibility strong plasticity. Moreover, adipose-derived stem cells (ADSCs) could enhance their wound healing ability through directional modification.
Colon adenocarcinoma (COAD), a frequently encountered and highly lethal malignancy of the digestive system, has been focus intensive research regarding its prognosis. The intricate immune microenvironment plays pivotal role in pathological progression COAD; nevertheless, underlying molecular mechanisms remain incompletely understood. This study aims to explore gene expression patterns COAD, construct robust prognostic model, delve into potential therapeutic targets for COAD liver metastasis,...
Abstract The high incidence and vulnerability to recurrence of bladder cancer (BLCA) is a challenge in the clinical. Recent studies have revealed that NFE2L3 plays vital role carcinogenesis progression different human tumors. However, BLCA has not been elucidated. In this study, expression was significantly increased samples. Its associated with advanced clinicopathological characteristics an independent prognostic factor for overall survival metastasis-free 106 patients BLCA. vitro vivo...
Background: Early detection and precise prognostic evaluation of clear cell renal carcinoma (ccRCC) are crucial for patient life expectancy. Ion channel-related genes (ICRGs) great diagnostic value as components that maintain the normal structure kidney. Therefore, we systematically explored diagnostic, prognostic, therapeutic ICRGs in ccRCC using multi-database. Methods: RNA transcriptome profiles clinical data patients were extracted integrated from public databases including The Cancer...
The coagulation system is closely related to the physiological status and immune response of body. Recent years, studies focusing on association between abnormalities tumor progression have been widely reported. In clear cell renal carcinoma (ccRCC), poor prognosis often occurs in patients with venous thrombosis abnormalities, there a lack research fields. Significant differences function were also demonstrated our clinical sample high ccRCC stage or grade. Therefore, this study, we analyzed...
Clear cell renal carcinoma (ccRCC) is characterized by the accumulation of lipid-reactive oxygen species. Ferroptosis, due to lipid peroxidation, has been reported be strongly correlated with tumorigenesis and progression. However, functions ferroptosis process in ccRCC remain unclear.After sample cleaning, data integration, batch effect removal, we used Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases screen out expression prognostic value ferroptosis-related lncRNAs...
Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in tumorigenesis progression numerous cancers. However, relationship between RBPs ccRCC is still unclear. Exploring potential biological functions establishing prognostic signature predict survival probability remains meaningful. In this study, transcriptome profiling corresponding clinical...
Background: Therapy-related neuroendocrine prostate cancer (NEPC) is a lethal castration-resistant (CRPC) subtype that, at present, lacks well-characterized molecular biomarkers. The clinical diagnosis of this disease dependent on biopsy and histological assessment: methods that are experience-based easily misdiagnosed due to tumor heterogeneity. development robust diagnostic tools for NEPC may assist clinicians in making medical decisions the choice continuing anti-androgen receptor therapy...
Clear cell renal carcinoma (ccRCC) is among the most common malignant tumors worldwide, with a high incidence rate and poor prognosis. Currently, there are no biomarkers that can accurately guide prognostic evaluation therapeutic strategy for ccRCC. The value potential biological function of claudin-8 (CLDN8), critical component tight junctions in ccRCC, remain unclear.Sequencing data were obtained from Cancer Genome Atlas, International Consortium, Gene Expression Omnibus databases. R...
In bladder and breast cancer, the claudin-low subtype is widely identified, revealing a distinct tumor microenvironment (TME) immunological feature. Although we have previously identified individual claudin members as prognostic biomarkers in clear cell renal carcinoma (ccRCC), existence of an intrinsic its interplay with TME clinical outcomes remains unclear.Transcriptomic data from The Cancer Genome Atlas (TCGA)- kidney (KIRC) cohort E-MTAB-1980 were derived training validation cohorts,...
Clear cell renal carcinoma (ccRCC) is one of the most common types malignant tumors and early detection contributes to a better prognosis. Finding new biomarkers for diagnosis or treatment remains meaningful. DEF6 guanine nucleotide exchange factor (DEF6) upregulated in ccRCC compared normal controls, but relationship between expression prognosis unclear. Moreover, potential biological functions In present study, Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), TISIDB clinical...
To explore the clinical value of three-dimensional image reconstruction technology (3DIT) on preoperative surgical planning and perioperative outcomes in laparoscopic pyeloplasty (LP).Data 25 patients with ureteropelvic junction obstruction (UPJO) admitted to our hospital from January 2018 2019 was analyzed retrospectively. All underwent enhanced computed tomography (CT) scanning. In 12 cases 3DIT group, involved use virtual operation morphometry based CT data into (3D) images. Surgery other...
To develop an original and standardized ureteral stricture disease (USD) score classification system for quantifying ureter characteristics, assessing complexity of the minimally invasive upper urinary tract reconstructive (UUTR) surgical procedure, formulating preoperative plans, offering objective comparisons techniques between different institutions surgeons.We retrospectively reviewed a test set 64 patients validation 170 who underwent UUTR surgery from January 2018 to 2021. Three...
Purpose: At present, how early screening for ccRCC is still a thorny issue urologists. Probing the mechanisms underlying development of and finding relevant prognostic biomarkers remains crucial. Therefore, we systematically analyzed APOBEC family in this study identified APOBEC3D as biomarker. Methods: In study, based on TCGA database, assessed expression prognosis potential bioinformatic pathways. We then constructed nomograms to predict patients better. Afterward, further focused our data...