A5101729229- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Protein purification and stability
- Electrospun Nanofibers in Biomedical Applications
- Polymer Surface Interaction Studies
- Bacteriophages and microbial interactions
- Membrane Separation Technologies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- SARS-CoV-2 detection and testing
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Influenza Virus Research Studies
- vaccines and immunoinformatics approaches
- MicroRNA in disease regulation
- Viral Infections and Immunology Research
- Advanced Sensor and Energy Harvesting Materials
- Vanadium and Halogenation Chemistry
- Inflammasome and immune disorders
- Cassava research and cyanide
- Gold and Silver Nanoparticles Synthesis and Applications
- Respiratory viral infections research
Langfang Normal University
2025
Northwest University
2024
Tianjin University of Science and Technology
2023-2024
China International Science and Technology Cooperation
2023-2024
State Key Laboratory of Digital Medical Engineering
2020-2024
Nankai University
2019-2024
Southeast University
2020-2024
Michigan Technological University
2013-2023
China Pharmaceutical University
2019-2023
Guangxi University
2021-2023
N6-methyladenosine (m6A) plays crucial roles in regulating RNA metabolisms. METTL16 identified as a single-component methyltransferase catalyzes m6A formation the nucleus; whether it regulates cytoplasmic fate remains unknown. Here, we detected dual localization of nucleus and cytoplasm. depletion attenuates protein synthesis, but activity is not required for its translation-promoting function. Mechanistically, an interactor METTL16, eIF4E2, which represses translation by acting competitor...
Adeno-associated virus (AAV) is showing promise as a therapy for diseases that contain single-gene deletion or mutation. One major scale-up challenge the removal of empty non-gene interest containing AAV capsids. Analytically, capsids can be separated from full using anion exchange chromatography. However, when scaled up to manufacturing, minute changes in conductivity are difficult consistently obtain. To better understand differences and capsids, we have developed single-particle atomic...
Virus colloidal behavior is governed by the interaction of viral surface and surrounding environment. One method to characterize virus charge isoelectric point (pI). Traditional determination pI has focused on bulk characterization a solution. However, capsids are extremely heterogeneous, single-particle may give more information range observed across population. measure chemical force microscopy (CFM). CFM technique that measures adhesion functionalized atomic microscope (AFM) probe and, in...
To mimic the bone matrix of mineralized collagen and to impart microporous structure facilitate cell migration regeneration, we developed a nanofibrous (NF) polymer scaffold with highly interconnected pores three-dimensional calcium phosphate coating utilizing an electrodeposition technique. The mineral content, morphology, crystal structure, chemical composition could be tailored by adjusting deposition temperature, voltage, duration. A higher voltage temperature led greater rate...
Abstract How to fully explore the personality characteristics of student users and implicit information in existing teaching resources, improve resources recommendation algorithm, alleviate problem overload learning disorientation brought by massive has become an important research topic modern smart education online education. In this paper, we first constructed a cognitive diagnosis model based on graph convolutional neural network (GCN), then resource joint probability matrix...
Complex coacervation shows promise as a strategy to improve the thermal stability of viruses for use in vaccine formulations.
Abstract Peptide-major histocompatibility complex I (MHC I) binding affinity prediction is crucial for vaccine development, but existing methods face limitations such as small datasets, model overfitting due to excessive parameters and suboptimal performance. Here, we present STMHCPan (STAR-MHCPan), an open-source package based on the Star-Transformer model, MHC peptide prediction. Our approach introduces attention mechanism improve deep learning network architecture performance in antigen...
Since the outbreak caused by a porcine epidemic diarrhea virus (PEDV) variant in 2010, current of PEDV genotype 2 (G2) has huge economic losses to pig industry China. In order better understand biological characteristics and pathogenicity field strains, 12 isolates were collected plaque purified during 2017 2018 Guangxi, The neutralizing epitopes spike proteins ORF3 analyzed evaluate genetic variations, they compared with reported G2a G2b strains. Phylogenetic analysis S protein showed that...
Coinfection caused by various genotypes of porcine epidemic diarrhea virus (PEDV) is a new disease situation. We previously reported the coexistence PEDV strains containing different ORF3 in China. In this study, 17GXCZ-1ORF3d and 17GXCZ-1ORF3c were isolated plaque-purified from same piglet, which had natural large deletion at 172-554 bp position gene or possessed complete gene, respectively. Meanwhile, >99% nt identity with 5'UTR, ORF1a/1b, S, E, M, N 3'UTR regions but only demonstrated low...
Adipogenesis is mediated by the complex gene expression networks involving posttranscriptional modifications. The natural compound rhein has been linked to regulation of adipogenesis, but underlying regulatory mechanisms remain elusive. Herein, we systematically analyzed effects on adipogenesis at both transcriptional and levels. Rhein remarkably suppresses in stage-specific dose-dependent manners. identified inhibit fat mass obesity-associated (FTO) demethylase activity. Surprisingly,...
Addition of osmolytes causes viruses-coated AuNPs to aggregate and not protein-coated AuNPs. Ligand-free detection virus was developed without the need for prior knowledge specific target.
Evidence has shown that microRNA (miRNAs) are involved in molecular pathways responsible for aging and age-related cognitive decline. However, there is a lack of research linked plasma exosome-derived miRNAs changes with function older people aging, which might prove new insight on the transformation clinical applications decline people.