A5101969583- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Molecular Junctions and Nanostructures
- Advanced biosensing and bioanalysis techniques
- Electrospun Nanofibers in Biomedical Applications
- Force Microscopy Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Quantum Dots Synthesis And Properties
- Nanofabrication and Lithography Techniques
- Chalcogenide Semiconductor Thin Films
- biodegradable polymer synthesis and properties
- Immunotherapy and Immune Responses
- Polymer Surface Interaction Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Graphene and Nanomaterials Applications
- Nanowire Synthesis and Applications
- Conducting polymers and applications
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- CRISPR and Genetic Engineering
- Telomeres, Telomerase, and Senescence
State Key Laboratory of Digital Medical Engineering
2016-2025
Southeast University
2016-2025
Jilin Normal University
2025
Xi'an University of Science and Technology
2024
Ipsen (United States)
2023
City Of Hope National Medical Center
2017
BioElectronics (United States)
2011-2016
Guangdong General Hospital
2015
University of Houston
2001-2011
Nanjing University
1998-2006
5-Fluorouracil (5-FU) has been commonly prescribed for patients with colorectal cancer (CRC), but resistance to 5-FU is one of the main reasons failure in CRC. Recently, microRNAs (miRNAs) have established as a means reversing dilemma by regulating signaling pathways involved initiation and progression However, how safely effectively deliver miRNA target cells becomes challenge.In this study, Engineered exosomes were exploited simultaneously an anticancer drug miR-21 inhibitor...
Cells release exosomes to transfer various molecules other cells. Exosomes are involved in a number of physiological and pathological processes. They emerging great potential utility for diseases diagnosis treatment recently. However, the internalization intracellular trafficking have not been described clearly. In this work, were isolated from culture medium PC12 cells, labeled by lipophilic dye amino-reactive fluorophore, incubated with resting The results live-cell microscopy indicated...
Among a variety of polymers, poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), microbial polyester, with biodegradable, nonantigenic, and biocompatible properties, is attracting more attention in tissue engineering. Hydroxyapatite (HA), similar to the mineral component natural bone, known be osteoconductive, nontoxic, noninflammatory. In this study, aligned random-oriented PHBV nanofibrous scaffolds loaded HA nanoparticles were fabricated through electrospinning technique. Mesenchymal...
Abstract Micro RNA s (mi s), a class of small s, are important molecules that influence several developmental processes and regulate interference ( i), abundant in animals, plants, plant tissues traditionally consumed the diet. The survival from diet however, remains unclear, persistence mi dietary plants animal gastrointestinal GI ) tract is still under debate. In this study, ICR mice were fed total quantities 10–50 μ g, extracted Brassica oleracea . Serum, feces, various collected after...
Programmed cell death ligand-1 (PD-L1) overexpressed on cancer cells has emerged as a key inhibitor that maintains the immunosuppressive microenvironment through its interaction with PD-1 receptor in cancer. Here, we demonstrated miR-424-5p delivery via extracellular vesicles (EVs) derived from adipose tissue-mesenchymal stromal (AT-MSCs) partly promotes proinflammation and enhances antitumor cytotoxicity vitro vivo. Triple negative breast (TNBC) exhibits increased expression of PD-L1, PD-L1...
Abstract Background Ovarian cancer (OC) is distinguished by its aggressive nature and the limited efficacy of current treatment strategies. Recent studies have emphasized significant role cancer-associated fibroblasts (CAFs) in OC development progression. Methods Employing sophisticated machine learning techniques on bulk transcriptomic datasets, we identified fibroblast growth factor 7 (FGF7), derived from CAFs, as a potential oncogenic factor. We investigated relationship between FGF7...
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a biodegradable polyester, has been good candidate of biomaterial employed in tissue engineering. However, the PHBV film is hydrophobic and no recognition sites for cell attachment. In this study, films are activated by ammonia plasma treatment to produce amino groups on surface, followed sequential reactions with heterobifunctional cross-linker containing segment poly(ethylene glycol) (PEG) further RGD-containing peptides. XPS analyses...
Abstract Background Sorafenib resistance poses therapeutic challenges in HCC treatment, which cancer stem cells (CSCs) plays a crucial role. CRISPR/Cas9 can be utilized as potential technique to overcome the drug resistance. However, safe, efficient and target specific delivery of this platform remains challenging. Extracellular vesicles (EVs), active components cell communication, hold promising benefits platform. Results Herein we report normal epithelial –derived EVs engineered with...
Stem cells used for clinical tissue regeneration therapy should have the capacity of self-renewal, high proliferation, and differentiation be able to transplanted in large numbers. Although concentrations epidermal growth factor (EGF) basic fibroblast (bFGF) may induce stem cells, these factors been widely enhance propagation including adipose-derived mesenchymal (ASCs). However, effects low EGF bFGF on need evaluated carefully. This study illustrates that (5 ng/mL) (10 increase...
A novel approach of using denatured bovine serum albumin (dBSA) to modify hydrophobic nanocrystals is reported. The dBSA layer outside can adsorb water insoluble drugs excellently via interactions. Further PEGylation the engineered greatly improves their aqueous stability. PEGylated modified upconversion nanoparticles, as a model for construction integrating imaging and drug delivery platform, were also studied. results demonstrated nanoparticles not only maintain unique up-conversion...
Abstract Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and a major cause death. However, molecular mechanisms underlying CRC initiation, growth metastasis are poorly understood. In this study, based on our previous work for comprehensively analyzing miRNA sequencing data, we examined series colorectal microRNAs expression profiles data. Results show that all these samples share same four pathways including TGF-beta signaling pathway, which important in carcinogenesis....
DNA methylation is one mechanism of epigenetic regulation in plants. Small interfering RNAs (siRNAs) targeted endogenous genes and caused the promoters to be hypermethylated, namely RNA-directed (RdDM). Repressor silencing 1 (ROS1) an active demethylase involved methylation. This study indicates that ROS1-mediated demethylation plays important roles regulating expression these stress response biotic stresses. Further experiments confirmed level ROS1 gene was significantly upregulated A....
Microenvironments in which cells live play an important role the attachment, growth and interactions of cells. To mimic natural structure extracellular matrices, electrospinning was applied to fabricate biomaterials into ultrafine fibers. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a biocompatible biodegradable polyester, has been shown be excellent biomaterial candidate for tissue engineering. In this study, five types PHBV fibrous scaffolds with different diameters orientations...
ABSTRACT Exosomes, the natural vehicles of intercellular communication, transfer proteins, mRNAs, and microRNAs (miRNAs) mediate many physiological pathological processes. It is not clear that whether exosomal miRNAs could regulate gene expression across species, though some studies suggest interactions between cells. In this report, we have isolated exosomes from rat PC12 cells assessed their internalization by human cancer Hela The internalized were located in lysosomes. Human PTEN was...