A5010622580- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- CRISPR and Genetic Engineering
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Single-cell and spatial transcriptomics
- Genetic Neurodegenerative Diseases
- Pain Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Animal Genetics and Reproduction
- Advanced Biosensing Techniques and Applications
- Folate and B Vitamins Research
- Nerve injury and regeneration
- Genetics, Aging, and Longevity in Model Organisms
- Immune cells in cancer
- Tissue Engineering and Regenerative Medicine
- Genomics and Rare Diseases
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nuclear Structure and Function
- Fish Biology and Ecology Studies
- Protein Degradation and Inhibitors
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Calpain Protease Function and Regulation
- Advanced biosensing and bioanalysis techniques
Institutul National Victor Babes
2019-2024
Carol Davila University of Medicine and Pharmacy
2024
University of Bucharest
2010-2023
Abstract Alterations in RNA-splicing are a molecular hallmark of several neurological diseases, including muscular dystrophies, where mutations genes involved RNA metabolism or characterized by alterations splicing have been described. Here, we present five patients from two unrelated families with limb-girdle dystrophy (LGMD) phenotype carrying biallelic variant SNUPN gene. Snurportin-1, the protein encoded SNUPN, plays an important role nuclear transport small ribonucleoproteins (snRNPs),...
Resident macrophages from dorsal root ganglia are important for the development of traumatic-induced neuropathic pain. In first 5-7 days after a traumatic sciatic nerve injury (i.e., spinal ligation (SNL), spared (SNI), transection or and transection), Ionized binding adapter protein 1 (Iba1) (+) resident cluster around neurons, possibly contributing to injury-induced hypersensitivity. Since infiltrating gradually recruited lesion site peak at about 7 days, few post-lesion offer window...
Despite recent advances in targeted cancer therapies, drug resistance remains an important setback tumor control. Understanding the complex mechanisms involved both innate and acquired represents first step discovering novel therapeutic agents. Because of its importance tumorigenesis, progression, metastasis, lipid metabolism is increasingly garnering attention. CD36 a membrane receptor at top signaling cascade that transports lipids. Its expression has been repeatedly presented as...
In aged muscle, satellite cells’ symmetric and asymmetric divisions are impaired, intrinsic extrinsic complex mechanisms govern these processes. This review presents many updated aspects regarding muscle stem fate in normal aging conditions. The balance between self-renewal commitment contributes to regeneration, homeostasis, aging, disease. Stimulating regeneration could be a therapeutic target, but there is still need understand the that influence each other cells their niche. We highlight...
Cell identity, a fundamental concept in biology, emerges from the interplay of gene expressions, cellular functions, and genomic fingerprints. Chimerism refers to presence two genetically distinct types cells within an individual. Monitoring chimerism is important tool evaluate evolution engraftment after transplant detect relapse underlying hematological neoplasm or occurrence graft rejection. Also, continuous monitoring essential that can provide guidance for early therapeutic...
Parkinson's Disease (PD) is a prevalent and escalating neurodegenerative disorder with significant societal implications. Despite being considered proteinopathy, in which the aggregation of α-synuclein main pathological change, intricacies PD initiation remain elusive. Recent evidence suggests potential link between gut microbiota initiation, emphasizing need to explore effects microbiota-derived molecules on neuronal cells. In this study, we exposed dopaminergic-differentiated SH-SY5Y cells...
Duchenne and Becker muscular dystrophy are X-linked recessive inherited disorders characterized by progressive weakness due to skeletal muscle degeneration. Different mutations in the DMD gene, which encodes for dystrophin protein, responsible these disorders. The aim of our study was investigate relationship between type, size, location mutation that occurs gene their effect on protein expression a cohort 40 male dystrophinopathy patients nine females, possible carriers. We evaluated...
The scope of this study is to investigate the expression dmrt1 , foxl2 ar star and sox9 genes in context gonad development stage 21 month‐old Best Beluga individuals. No significant difference was observed between males females but cyp17a1 gene showed higher male than female gonads. results suggest that during sampling were perinucleolar early spermatogenesis which led specific patterns for investigated genes.