A5059423888- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Ion Channels and Receptors
- Lipid Membrane Structure and Behavior
- Cardiac electrophysiology and arrhythmias
- Neurobiology and Insect Physiology Research
- stochastic dynamics and bifurcation
- Ion Transport and Channel Regulation
- Quantum chaos and dynamical systems
- Neuroscience and Neuropharmacology Research
- Click Chemistry and Applications
- Neural dynamics and brain function
- Advancements in Transdermal Drug Delivery
- HIV/AIDS drug development and treatment
- Biochemical effects in animals
- Neuroscience and Neural Engineering
- Spectroscopy and Quantum Chemical Studies
- Heart Rate Variability and Autonomic Control
- Photoreceptor and optogenetics research
- HIV Research and Treatment
- Nitric Oxide and Endothelin Effects
- Computational Drug Discovery Methods
- Biochemical Analysis and Sensing Techniques
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
University of Bucharest
2004-2017
Ludwig-Maximilians-Universität München
1988
The capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1), acts as a polymodal detector of pain-producing chemical and physical stimuli in sensory neurons. Hyperglycemia hypoxia are two main phenomena diabetes associated with several complications. Although many studies on streptozotocin-induced diabetic rats indicate that early neuropathy is potentiation TRPV1 activity dorsal root ganglion neurons, its underlying mechanism distinctive roles hyperglycemia have not been...
In this short note we propose a simple and rapid procedure to calculate the net quantity of metabolites absorbed by hepatocytes from blood plasma. The movement through sinusoids determines an opposed circulation plasma space Disse. Hydrodynamic considerations lead conclusion that absorb for their own synthesis processes in volume flow order 10-12 nl s-1 sieve plate surface with area 1 µm2. At pathological temperature (40 °C), excess entire sinusoidal mammalian liver may be as high 1.9 s-1....
Nebivolol is a highly selective beta(1)-adrenoceptor antagonist with vasodilator properties involving the vascular endothelium, but its effect on smooth muscle cells (SMC) still unclear. In this paper, we tested of nebivolol renal artery and investigated cellular mechanism involved. To purpose, denuded arteries isolated from mice were studied in vitro using myograph nitric oxide (NO) sensor techniques, while SMC culture analyzed by patch-clamp technique. The technique was used to assay...
Analgesia induced by certain tricyclic antidepressants has been largely used for decades, yet the mechanisms involved are incompletely understood. Starting from previously reported dual effects of amitriptyline on wild-type ENaC (Pena F, et al. J Pharm Pharmacol 54:1393-8: 2002), we extended our study to ASIC1a performing a series whole cell and single-channel recordings proton-activated currents in HEK293 cells. Acid pulses were applied at 2 or 5 min intervals, (1-500 μM) was holding pH 7.4...
Abstract The predicted inhibition constant (Ki) and the inhibitor concentration (IC90) of HIV‐1 protease (HIV‐1 PR) inhibitors: symmetric nonsymmetric ‐ benzyl, ketone, oxime, pyrazole, imidazole, triazole cyclic urea derivatives, were obtained by 3D‐CoMFA (Comparative Molecular Field Analysis) method. CoMFA statistical parameters: cross‐validate correlation coefficient (q2), higher than 0.5, fitted (r2), 0.90 validated biological activities. best predictions found for trifluoromethyl...