A5022422208- Sulfur Compounds in Biology
- Nitric Oxide and Endothelin Effects
- Redox biology and oxidative stress
- Neuroscience of respiration and sleep
- Ion Channels and Receptors
- Electron Spin Resonance Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced Glycation End Products research
- Heme Oxygenase-1 and Carbon Monoxide
- Neurobiology and Insect Physiology Research
- Metal-Catalyzed Oxygenation Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Renin-Angiotensin System Studies
- Genomics, phytochemicals, and oxidative stress
- Graphene and Nanomaterials Applications
- Hemoglobin structure and function
- Trace Elements in Health
- Folate and B Vitamins Research
- Graphene research and applications
- Industrial Gas Emission Control
- Postharvest Quality and Shelf Life Management
- RNA and protein synthesis mechanisms
Leibniz Institute for Analytical Sciences - ISAS
2020-2025
University of Glasgow
2025
Université Libre de Bruxelles
2023
Kirchhoff (Germany)
2021-2023
Leibniz Institute for Neurobiology
2021
Université de Bordeaux
2016-2020
Friedrich-Alexander-Universität Erlangen-Nürnberg
2010-2020
Institut de Biochimie et Génétique Cellulaires
2016-2020
Centre National de la Recherche Scientifique
2016-2019
University of Prishtina
2015
Abstract Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways with pharmacological endpoints high significance in the treatment heart failure. Beneficial HNO effects depend, part, on its ability to release calcitonin gene-related peptide (CGRP) through an unidentified mechanism. Here we propose generated as result reaction two gasotransmitters NO and H 2 S. We show S production colocalizes transient receptor potential channel A1 (TRPA1), activates...
Dihydrogen sulfide recently emerged as a biological signaling molecule with important physiological roles and significant pharmacological potential. Chemically plausible explanations for its mechanisms of action have remained elusive, however. Here, we report that H2S reacts S-nitrosothiols to form thionitrous acid (HSNO), the smallest S-nitrosothiol. These results demonstrate that, at cellular level, HSNO can be metabolized afford NO+, NO, NO– species, all which distinct consequences their...
Abstract Protein S‐sulfhydration (forming ‐S‐SH adducts from cysteine residues) is a newly defined oxidative posttranslational modification and plays an important role in H 2 S‐mediated signaling pathways. In this study we report the first selective, “tag‐switch” method which can directly label protein S‐sulfhydrated residues by forming stable thioether conjugates. Furthermore demonstrate that S alone cannot lead to two possible physiological mechanisms include reaction with sulfenic acids...
Hydrogen sulfide (H2S) elicits pleiotropic physiological effects ranging from modulation of cardiovascular to CNS functions. A dominant method for transmission sulfide-based signals is via posttranslational modification reactive cysteine thiols persulfides. However, the source persulfide donor and whether its relationship H2S as a product or precursor controversial. The transsulfuration pathway enzymes can synthesize (Cys-SSH) cystine and/or homocysteine. Recently, Cys-SSH was proposed...
H<sub>2</sub>S signals<italic>via</italic>protein persulfidation. To be regulatory the modification will have to reversible. Using a new method for persulfide detection, we discover this missing link and show that thioredoxin system acts as depersulfidase<italic>in vivo</italic>.
Alzheimer's disease (AD), the most common cause of dementia and neurodegeneration in elderly, is characterized by deterioration memory executive motor functions. Neuropathologic hallmarks AD include neurofibrillary tangles (NFTs), paired helical filaments, amyloid plaques. Mutations microtubule-associated protein Tau, a major component NFTs, its hyperphosphorylation AD. We have shown that signaling gaseous molecule hydrogen sulfide (H2S) dysregulated during aging. H2S signals via...
Abstract Inhibition of the master growth regulator mTORC1 (mechanistic target rapamycin complex 1) slows ageing across phyla, in part by reducing protein synthesis. Various stresses globally suppress synthesis through integrated stress response (ISR), resulting preferential translation transcription factor ATF-4. Here we show C. elegans that inhibition or increases ATF-4 expression, and mediates longevity under these conditions independently ISR signalling. promotes activating canonical...
Abstract Small, gaseous molecules such as nitric oxide, carbon monoxide and hydrogen sulfide are produced signalling in mammalian cells. Here, we show that low concentrations of cyanide generated endogenously various tissues We detect several cellular compartments human cells the blood mice. Cyanide production is stimulated by glycine, occurs at pH lysosomes requires peroxidase activity. When a specific rate, exerts stimulatory effects on mitochondrial bioenergetics, cell metabolism...
Enzymes in the sulfur network generate signaling molecule, hydrogen sulfide (H2S), from amino acids cysteine and homocysteine. Since it is toxic at elevated concentrations, cells are equipped to clear H2S. A canonical oxidation pathway operates mitochondria, converting H2S thiosulfate sulfate. We have recently discovered ability of ferric hemoglobin oxidize iron-bound hydropolysulfides. In this study, we report that myoglobin exhibits a similar capacity for oxidation. trapped characterized...
Taking NO for an answer: A mechanistic study has shown that a heme-iron-catalyzed pathway (see scheme) could lead to the nitrite-/sulfide-induced formation of and HNO within mitochondria, suggests H2S may be elusive thiol responsible reduction nitrite. This offers answer decades-old question on role nitrite in treatment poisoning. As service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed re-organized online delivery,...
Abstract Thermosensitive Transient Receptor Potential (TRP) channels are believed to respond either cold or heat. In the case of TRP subtype A1 (TRPA1), there seems be a species-dependent divergence in temperature sensation as non-mammalian TRPA1 is heat-sensitive whereas mammalian sensitive cold. It has been speculated but never experimentally proven that and other temperature-sensitive ion have inherent capability responding both Here we show redox modification ligands affect human...
Hydrogen sulfide (H2S) has been increasingly recognized as an important signaling molecule that regulates both blood pressure and neuronal activity. Attention drawn to its interactions with another gasotransmitter, nitric oxide (NO). Here, we provide evidence the physiological effects observed upon application of sodium nitroprusside (SNP) H2S can be ascribed generation nitroxyl (HNO), which is a direct product reaction between SNP H2S, not consequence released NO subsequently reacting H2S....
Hydrogen sulfide (H
The gasotransmitter hydrogen sulfide (H