A5057780062- Ion Channels and Receptors
- Gastrointestinal motility and disorders
- Herbal Medicine Research Studies
- Adipose Tissue and Metabolism
- Respiratory and Cough-Related Research
- Diet, Metabolism, and Disease
- Advances in Cucurbitaceae Research
- SARS-CoV-2 and COVID-19 Research
- High Altitude and Hypoxia
- Analytical Chemistry and Chromatography
- Inflammatory Bowel Disease
- Cervical Cancer and HPV Research
- Trace Elements in Health
- Natural Antidiabetic Agents Studies
- Antibiotic Use and Resistance
- Selenium in Biological Systems
- Crop Yield and Soil Fertility
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Neuropeptides and Animal Physiology
- Pharmacological Effects and Assays
- Sperm and Testicular Function
- Cardiac Fibrosis and Remodeling
- Algorithms and Data Compression
- Poxvirus research and outbreaks
Friedrich-Alexander-Universität Erlangen-Nürnberg
2011-2023
King Fahd Medical City
2012-2023
Mackay Base Hospital
2023
University College Dublin
2021
Technical University of Munich
2021
Universitätsklinikum Erlangen
2015-2020
Sandia National Laboratories California
2016
North South University
2015
King Saud bin Abdulaziz University for Health Sciences
2012-2014
University of Sargodha
2014
This study was performed to investigate the protective and therapeutic effects of resveratrol (RES) against CdCl2-induced toxicity in rat testes. Seven experimental groups adult male rats were formulated as follows: A) controls+NS, B) control+vehicle (saline solution hydroxypropyl cyclodextrin), C) RES treated, D) CdCl2+NS, E) CdCl2+vehicle, F) followed by CdCl2 M) RES. At end protocol, serum levels FSH, LH testosterone measured all groups, testicular TBARS superoxide dismutase (SOD)...
We demonstrate a novel dual strategy against inflammation and pain through body-wide desensitization of nociceptors via TRPA1. Attenuation experimental colitis by capsazepine (CPZ) has long been attributed to its antagonistic action on TRPV1 associated inhibition neurogenic inflammation. In contrast, we found that CPZ exerts anti-inflammatory effects profound Micromolar induced calcium influx in isolated dorsal root ganglion (DRG) neurons from wild-type (WT) but not TRPA1-deficient mice....
Background and aims The recent monkeypox (Mpox) outbreak confirmed by the World Health Organization (WHO) underscores importance of evaluating knowledge attitude medical students toward emerging diseases, given their potential roles as healthcare professionals sources public information during outbreaks. This study aimed to assess students’ about Mpox identify factors affecting level in low-income high-income countries. Methods A cross-sectional was conducted on 11,919 from 27...
The adipose tissue is not only an inert storage depot for lipids, but also it secretes a variety of bioactive molecules, known as adipokines, which affect whole-body homeostasis. Adiponectin the most abundant these adipocytokines and to have regulatory effect on metabolism glucose lipid. main objectives this study were evaluate serum levels adiponectin establish correlation between degree insulin resistance in type 2 diabetic patients. Eighty participants enrolled study; 61 patients 19...
Background Various transient receptor potential (TRP) channels in sensory neurons contribute to the transduction of mechanical stimuli colon. Recently, even cold-sensing menthol TRPM(melastatin)8 was suggested be involved murine colonic mechano-nociception. Methods To analyze roles TRPM8, TRPA1 and TRPV4 distension-induced nociception pain, TRP-deficient mice selective pharmacological blockers wild-type (WT) were used. Visceromotor responses (VMR) colorectal distension (CRD) vivo recorded...
Problem statement: Cadmium is one of the most dangerous occupational and environmental toxins. It found in drinking water, atmospheric air even food. reported to be very toxic biological systems. Until now treating intoxication with this metal, chelating Compounds have been used, burdened numerous undesirable symptoms. For reason, many researches are carried out countries find natural-made compounds that help protection against cadmium induced toxicity fewer or no side effects. This study...
In 2020, the World Health Organization has characterized COVID-19, a disease caused by infection with SARS-CoV-2 virus, as pandemic. Although few vaccines and drugs have been approved to, respectively, prevent or treat disease, several clinical trials are still ongoing to test new mitigate burden of Few studies shown role host genetics in prognosis drug response highlighting importance diverse participation COVID-19 trials. The goal this study is assess public attitudes Egypt, Saudi Arabia,...
Cervical cancer is a highly prevalent disease among women worldwide. However, the advent of vaccine against HPV, main cause disease, has prevented its spread. The acceptability HPV to different sectors Saudi community yet be clarified. Since parents and teachers are major influencers in decision-making process vaccination for this study aimed assess knowledge attitudes toward cervical cancer, vaccine, unraveled factors that would influence recommending vaccine.
This study compared the effect of low-fat diet (LFD) and high-fat rich in corn oil (HFD-CO) on left ventricular (LV) fibrosis rats examined their angiotensin II (ANG II), JAK/STAT, TGF-1β/smad3 pathways. As to LFD which didn't affect any measured parameters, HFD-CO-induced type 2 diabetes phenotype increased LV collagen synthesis. Mechanistically, it levels ROS, ANG II, ACE, IL-6, s-IL-6Rα, TGF-β1, Smad-3, activities JAK1/2 STAT1/3. AG490, a JAK2 inhibitor, partially ameliorated these while...
Purpose: To determine the major reasons, sources, diseases and drugs responsible for increasing trend of self-medication.Method: A community-based cross-sectional survey was carried out in district Faisalabad Pakistan. Respondents (1488) were classified on basis age, sex, education, lifestyle their economical level. questionnaire distributed among sample population to collect data.Results: Majority respondents involved self-medication aged between 15 20 years. Family members (N = 717, 48 %)...
Diabetic metabolism causes changes of the chemical milieu including accumulation reactive carbonyl species, for example, methylglyoxal (MGO). MGO activates chemosensitive TRPA1 on nociceptors, but contribution to neuronal pathophysiology causing pain and hyperalgesia in diabetic neuropathy is not fully understood.We employed single-nerve-fiber recordings type 2 diabetes patients with (spDN) without cutaneous (DN) streptozotocin-diabetic healthy mice. In mice, we measured Ca++ transients...
Background Citrullus colocynthis pulp seedless extract has been demonstrated to have antihyperglycemic and insulinotropic effects. Problem statement: The mechanism(s) underlying the effects not investigated date. Approach: influence of administered orally was studied in alloxan diabetic white albino rats. Rats were divided into four groups, first group normal non rats given saline named control group, second treated-diabetic rats, third fourth treated with or glybenclamide (a positive...
Problem statement: The goal of the current investigation was to clarify effects Citrullus colocynthis pulp extract on structure liver diabetic rats at both light and scanning electron microscopic levels. Approach: Forty-eight adult male albino were equally allocated into four groups: Group1: control, Group 2: colocynthis-treated, 3: Group4: treated with colocynthis. All treatments administered via an intragastric tube. Diabetes induced in groups 3 4 by intraperitoneal injection alloxan....
In Saudi Arabia, the HPV vaccine is administered to young females through school-based immunization programs; however, program's efficacy depends on parental consent, with physicians acting as primary determinants in decision-making regarding vaccination.