A5079398505- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Metabolism, Diabetes, and Cancer
- Vitamin C and Antioxidants Research
- Inflammatory mediators and NSAID effects
- Adipokines, Inflammation, and Metabolic Diseases
- Liver physiology and pathology
- Vanadium and Halogenation Chemistry
- Advanced Glycation End Products research
- Mesenchymal stem cell research
- Liver Disease and Transplantation
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Apelin-related biomedical research
- Natural Antidiabetic Agents Studies
- Organ Transplantation Techniques and Outcomes
- Folate and B Vitamins Research
- Bone Metabolism and Diseases
- Antioxidant Activity and Oxidative Stress
- Diabetes Management and Research
- High Altitude and Hypoxia
- Chronic Kidney Disease and Diabetes
- Esophageal and GI Pathology
Cairo University
2014-2024
Al-Azhar University
2022
Laboratoire National de Référence
2021
King Khalid University
2009-2020
University of Bamako
2020
Czech Academy of Sciences, Institute of Physiology
2016
Pharmacochimie et Pharmacologie pour le Développement
2015
King Saud University
2003
This study was performed to investigate the protective and therapeutic effects of resveratrol (RES) against CdCl2-induced toxicity in rat testes. Seven experimental groups adult male rats were formulated as follows: A) controls+NS, B) control+vehicle (saline solution hydroxypropyl cyclodextrin), C) RES treated, D) CdCl2+NS, E) CdCl2+vehicle, F) followed by CdCl2 M) RES. At end protocol, serum levels FSH, LH testosterone measured all groups, testicular TBARS superoxide dismutase (SOD)...
Progress in the study of Covid-19 disease rodents has been hampered by lack angiotensin-converting enzyme 2 (ACE2; virus entry route to target cell) affinities for spike proteins across species. Therefore, we sought determine whether a modified protocol lipopolysaccharide (LPS)-induced acute respiratory distress syndrome rats can mimic both cell signalling pathways as well severe phenotypes disease. Rats were injected via intratracheal (IT) instillation with either 15 mg/kg LPS (model group)...
Abstract The potential inhibitory effect of the antidiabetic and anti‐inflammatory drug, metformin on thioacetamide (TAA)‐induced hepatotoxicity associated with inhibition mammalian target rapamycin (mTOR)–hypoxia‐inducible factor‐1α (HIF‐1α) axis has not been investigated before. Therefore, we tested whether can protect against liver injuries including fibrosis induced by TAA possibly via downregulation mTOR–HIF‐1α profibrogenic inflammatory biomarkers. Rats either injected (200 mg/kg;...
Diabetes is the most common cause of end-stage renal disease, also called kidney failure. The link between artery receptor angiotensin II type I (AT1R) and endothelin-1 (ET-1), involved in vasoconstriction, oxidative stress, inflammation fibrosis (collagen) diabetes-induced nephropathy with without metformin incorporation has not been previously studied. (type 2) was induced rats another group started (200 mg/kg) treatment 2 weeks prior to induction diabetes continued on until being culled...
The intermediate filament protein desmin is essential for maintaining the structural integrity of sarcomeres, fundamental unit cardiac muscle. Diabetes mellitus (DM) can cause to become dysregulated, following episodes nitrosative stress, through activation iNOS/mTOR/TIMP-1 pathway, thereby stimulating collagen deposition in myocardium. In this study, type 2 diabetes (T2DM) was induced rats. One group animals pre-treated with metformin (200 mg/kg) prior induction and subsequently kept on...
Food additives such as nitrates and nitrites, monosodium glutamate (MSG) used in the food industry increase risk of certain cancers inflict damage to vital organs. We sought determine whether antioxidant vitamin E can protect against liver injuries induced by a toxic dose MSG rat model MSG-induced acute injury. The group rats received daily (4 gm/kg) for 7 days, whereas protective groups were either 100 mg/kg plus or 300 days. Rats then sacrificed at day 8. Transmission light microscopy...
Acute renal failure induced by a toxic dose of acetaminophen (also known as paracetamol, or APAP) is common in both humans and experimental animal models. Glomerular ultrastructural alterations APAP overdose associated with the suppression biomarkers kidney injury have not been investigated before. Also, we whether combined polyphenolic antioxidants anti-inflammatory compounds, resveratrol (RES) quercetin (QUR) can protect against APAP-induced nephrotoxicity. Rats either received single (2...
Ankyloblepharon filiform adnatum is a rare congenital condition. We report the case of premature eutrophic neonate delivered vaginally at 32 weeks' gestation, weighing 1250 g, female, from an unattended twin pregnancy. The eyelids were partially connected by membrane on outer 1/3 right eye and almost completely left eye. second newborn died 24 hours after delivery. examined without any particularities. There no associated malformations. received two months birth. Management was surgical...
Abstract:Aim: To investigate the possible role of oxidative stress as a common mediator apoptosis and cardiac damage in diabetes. Materials Methods: This experimental work was conducted on 5 groups Wistar rats. Group I control group. Diabetes type 1 induced other (by streptozotocin) animals received insulin or vitamin E (300 mg /kg body weight), both E, no treatment for 4 weeks according to their At end study, serum tissues were examined biochemical parameters function, apoptosis. Electron...
Objective: Diabetic complications such as cardiovascular disease and osteoarthritis (OA) are among the common public health problems. The effect of insulin on OA secondary to diabetes has not been investigated before in animal models. Therefore, we sought determine whether insulin-mimicking agent, vanadium can protect from developing diabetic rats. Methods: Type 1 mellitus (T1DM) was induced Sprague–Dawley rats treated with and/or vanadium. Tissues harvested articular cartilage knee joint...
Amiodarone (AMD) is one of the highly effective antiarrhythmic agents used for treating refractory arrhythmias. It well known to have long-term administration side effects such as nephrotoxicity. The possible ameliorative antioxidant grape seed extract; on extent tissue damage in AMD-induced nephrotoxicity has not been investigated before. Twenty-four albino rats were this study and divided into four groups (n = 6). 1st group served an untreated control group, under same laboratory...
Liver fibrosis is a hallmark of thioacetamide (TAA) intoxications. MicroRNAs (miRs), such as miR-155, have been implied in the pathogenesis liver disease, and regulated by antioxidant anti-inflammatory compound resveratrol (RES). The link between reactive oxygen species (ROS), tumour suppressor p53 (p53), fibrosis-during TAA-induced injury-associated with miR-155 dysregulation without RES incorporation has not previously studied. Therefore, one group rats received TAA injections 200 mg/kg;...
Background Citrullus colocynthis pulp seedless extract has been demonstrated to have antihyperglycemic and insulinotropic effects. Problem statement: The mechanism(s) underlying the effects not investigated date. Approach: influence of administered orally was studied in alloxan diabetic white albino rats. Rats were divided into four groups, first group normal non rats given saline named control group, second treated-diabetic rats, third fourth treated with or glybenclamide (a positive...
The potential protective effects of resveratrol (RES) on the modulation hepatic biomarkers apoptosis and survival, p53-Bax axis, B-cell lymphoma 2 (Bcl-2) in an animal model paracetamol-induced acute liver injury have not been investigated before.The group rats received a single dose paracetamol (2 g/kg, orally), whereas were pretreated for 7 days with RES (30 mg/kg, i.p.) before they given paracetamol. All then sacrificed 24-h post ingestion.Histology images showed that overdose induced...
Cholestasis caused by slowing or blockage of bile flow is a serious liver disease that can lead to fibrosis and cirrhosis. The link between transforming growth factor beta 1 (TGFβ1), Smad family member 3 (Smad3), microRNA 21 (miR21) in duct ligation (BDL)-induced the presence absence anti-inflammatory antioxidant compound, resveratrol (RSV), has not been previously studied. Therefore, we tested whether RSV protect against BDL-induced associated with inhibition TGFβ1-Smad3-miR21 axis...