(1) Background: Since its discovery, COVID-19 has caused more than 256 million cases, with a cumulative death toll of 5.1 million, worldwide. Early identification patients at high risk mortality is great importance in saving the lives patients. The study aims to assess utility various inflammatory markers predicting among hospitalized COVID-19. (2) Methods: A retrospective observational was conducted 108 laboratory-confirmed between 1 May 2021 and 31 October Municipal Emergency Clinical...

Universal COVID-19 immunization is seen as a critical approach for limiting the spread of SARS-CoV-2 and reducing danger new variations emerging in general population, especially pregnant women. The literature accessible research data indicate that vaccination intentions vary greatly by country, with Romania ranking among European nations lowest rates. Thus, we aimed to investigate prevalence extent vaccine hesitancy women factors influencing their decision. A cross-sectional study was...

Globally, COVID-19 vaccines are currently being used to prevent transmission and reduce morbidity death associated with SARS-CoV-2 infection. Current research reveals that such as BNT162b2 Ad26.COV2.S highly immunogenic have high short-term effectiveness for most of the known viral variants. Clinical trials showed satisfying results in general population, but reluctance testing vaccinating pregnant women left this category little evidence regarding safety, efficacy, immunogenicity following...

Clinical trials for COVID-19 vaccines initially excluded pregnant women due to safety concerns, and when the were authorized emergency use, they not recommended this population. However, observational studies discovered that infected with have higher risks of negative pregnancy delivery outcomes compared non-pregnant women, raising question risks-benefits administering women. By mid-2021, there was general consensus on relative vaccination during pregnancy; therefore, it is critical...

In many countries, preterm birth, defined as birth before 37 completed weeks of gestation, is the primary cause infant death and morbidity. An increasing body research suggests that inflammation (both clinical subclinical) plays a significant role in inducing labor or developing pregnancy problems lead to premature birth. Consequently, purpose this was determine predictive value Neutrophil-Lymphocyte Ratio (NLR), derived (dNLR), Monocytes-to-Lymphocyte (MLR), Platelets-to-Lymphocyte (PLR),...

During the COVID-19 pandemic, it was observed that patients with heart disease are more likely to be hospitalized and develop severe COVID-19. Cardiac takes top position among patient comorbidities, failure (HF) prevalence reaching almost 5% in general population older than 35 years Romania. This retrospective study aimed determine potential use of NYHA classification for HF as prognostic tool in-hospital mortality, length hospitalization, probability rehospitalization decompensation. We...

SARS-CoV-2 infection produces alterations in blood clotting, especially severe cases of COVID-19. Abnormal coagulation parameters patients with COVID-19 are important prognostic factors disease severity. The objective this study was to evaluate the predictive value aPTT, D-dimer, INR and PT mortality A retrospective, single-center, observational conducted on admitted Municipal Emergency Clinical Hospital Timisoara, Romania, between August October 2021. Patients were confirmed as positive by...

Magnesium may contribute to the immune response during and after SARS-CoV-2 infection by acting as a cofactor for immunoglobulin production other processes required T B cell activity. Considering magnesium recommended dietary supplement pregnancy possible role of deficiency in COVID-19 its complications, current study sought determine effect magnesium-containing nutritional supplements on following pregnant women, well observe differences outcomes based taken pregnancy. The followed...

To date, the COVID-19 pandemic has caused millions of deaths across world. Prognostic scores can improve clinical management diagnosis and treatment. The objective this study was to assess predictive role 4C Mortality, CURB-65, NEWS in mortality among Romanian population. A single-center, retrospective, observational conducted on patients with reverse transcriptase-polymerase chain reaction (RT-PCR)-proven admitted Municipal Emergency Clinical Hospital Timisoara, Romania, between 1 October...

The aim of this study was to assess whether nebivolol treatment could have beneficial effects in the prevention anthracyclines-induced cardiotoxicity.Our prospective included 60 women, mean age 52.6±13 years, with HER2 negative breast cancer, scheduled undergo doxorubicin. patients were randomly divided into two groups: group (n=30) which received 5 mg once daily for duration chemotherapy and control without nebivolol. Cytostatic performed doxorubicin 70 mg/m2 administered intravenously...

Postpartum depression is a major mental health disorder that can negatively affect both mother and baby. In addition, the COVID-19 pandemic associated with extreme measures of lockdown had profound effects on humanity, increasing rates anxiety depression, especially among women in postpartum period. The aim this study was threefold: to determine prevalence compare at two different times during pandemic, assess possible association between timing childbirth given period risk depression. A...

COVID-19 has been associated with cardiovascular consequences, including myocardial infarction, thromboembolic events, arrhythmia, and heart failure. Numerous overlapping mechanisms, such as the IL-6 dependent cytokine storm unopposed angiotensin II stimulation, could be responsible for these consequences. Cardiac damage is hypothesized to a consequence of direct viral infection cardiomyocytes, resulting in increased metabolic demand, immunological activation, microvascular dysfunction....

We designed and implemented a prospective study to analyze the maternal neonatal outcomes associated with COVID-19 determine likelihood of viral transmission fetus newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, breast milk. The followed observational design, starting in July 2020 lasting for one year. A total 889 pregnant women were routinely tested SARS-CoV-2 infection an outpatient setting at our clinic, using nasal swabs PCR testing. 76 diagnosed...

Two years after the outbreak of COVID-19 pandemic, disease continues to claim victims worldwide. Assessing disease's severity on admission may be useful in reducing mortality among patients with COVID-19. The present study was designed assess prognostic value SOFA and qSOFA scoring systems for in-hospital included 133 proven by reverse transcriptase polymerase chain reaction (RT-PCR) admitted Municipal Emergency Clinical Hospital Timisoara, Romania between 1 October 2020 15 March 2021. Data...

Several investigations have revealed that COVID-19 causes a significant death rate due to acute respiratory distress syndrome, alterations in the quantity of ACE2 receptor expression, or intensity cytokine storm. Similarly, patients with hepatic impairment are co-infected SARS-CoV-2 more likely display upregulations receptors and storm overload, which exacerbates impairment, potentially increasing rate. Moreover, it is expected aging population develops higher degree fibrosis association...

Premature birth is a worldwide health issue, posing high mortality risk for newborns, as well causing emotional and financial difficulties, long-term issues patients. Identifying effective predictors preterm essential prolonging gestation or improving obstetric care. As invasive methods are costly, risky, not universally available, we aim to assess the predictive capacity of various serum parameters in pregnant women during third trimester, non-invasive alternative. Based on previous...

The purpose of this retrospective study was to evaluate the prognostic impact systolic blood pressure (SBP) and heart rate (HR) on in-hospital mortality in ST-segment elevation acute myocardial infarction (STEMI) patients, after primary percutaneous intervention (PCI).The included 294 patients admitted for STEMI. They were divided into five groups according SBP at admission: group I, <105 mmHg; II, 105-125 III, 126-140 IV, 141-158 V, ≥159 mmHg. Increased HR defined as ≥80 beats per minute...

Widespread COVID-19 vaccination is crucial for limiting the spread of SARS-CoV-2 and minimizing risk novel variants arising in general population, especially pregnant women. According to publicly available research data, intentions vary significantly by country, with Romania among European countries lowest rates. Thus, we sought determine scale acceptance campaign women Romania, as well variables affecting their choices. A cross-sectional study was conducted on referred Obstetrics Gynecology...

(1) Background: This study aims to evaluate the association of CRP, NLR, IL-6, and Procalcitonin with lung damage observed on CT scans; (2) Methods: A cross-sectional was performed among 106 COVID-19 patients hospitalized in Timisoara Municipal Emergency Hospital. Chest laboratory analysis were all patients. The rank Spearmen correlation used assess between inflammatory markers involvement. In addition, ROC curve determine accuracy diagnosis severe damage; (3) Results: IL-6 significantly...

This study aimed to assess the serum levels of intracellular adhesion molecule (sICAM-1), and vascular cell (sVCAM-1), in first psychotic episode schizophrenia (SZ) patients, before after six months antipsychotic treatment.The included 50 patients with a hospitalization for SZ healthy control subjects that were patient-matched regarding age, gender, body mass index smoking status. The evaluation presence cardiovascular risk factors, measurements systolic diastolic blood pressure, index,...

Studies observed that women infected with SARS-CoV-2 during pregnancy had a higher risk of preterm birth. Although it is likely COVID-19 the late trimester can trigger premature birth, prematurity remains concern, and vital to study additional clinical biological patient factors are highly associated this negative outcome allow for better management based on existing predictors. In order achieve goal, current retrospectively recruited 428 pregnant patients were separated into three groups...

Thrombospondin-1 (TSP-1) is a potent endogenous inhibitor of both physiological and pathological angiogenesis, widely studied as target in drug development for treating cancer. Several studies performed the cardiovascular field on TSP-1 are contradictory, role physiopathology disorders (CVDs) being, moment, incompletely understood may be due to presence several domains its structure which can stimulate many cellular receptors. It has been reported inhibit NO-mediated signaling act tissue...

Considering the worldwide impact of heart failure, it is crucial to develop approaches that can help us comprehend its root cause and make accurate predictions about outcome. This essential for lowering suffering death rates connected with this widespread illness. Cardiomyopathies frequently result from genetic factors, study failure genetics advancing quickly. Dilated cardiomyopathy (DCM) most prevalent kind cardiomyopathy, encompassing both hereditary nongenetic abnormalities. It...

Background: Several risk scores were developed for acute coronary syndrome (ACS) patients, but their use is limited by complexity. Purpose: The purpose of this study was to identify predictors at admission in-hospital mortality in ACS patients western Romania, using a simple risk-assessment tool – the new Canada (C-ACS) score. Patients and methods: baseline admitted with retrospectively assessed C-ACS score ranged from 0 4; 1 point assigned presence each following parameters: age ≥75 years,...