(1) Background: Since its discovery, COVID-19 has caused more than 256 million cases, with a cumulative death toll of 5.1 million, worldwide. Early identification patients at high risk mortality is great importance in saving the lives patients. The study aims to assess utility various inflammatory markers predicting among hospitalized COVID-19. (2) Methods: A retrospective observational was conducted 108 laboratory-confirmed between 1 May 2021 and 31 October Municipal Emergency Clinical...

Universal COVID-19 immunization is seen as a critical approach for limiting the spread of SARS-CoV-2 and reducing danger new variations emerging in general population, especially pregnant women. The literature accessible research data indicate that vaccination intentions vary greatly by country, with Romania ranking among European nations lowest rates. Thus, we aimed to investigate prevalence extent vaccine hesitancy women factors influencing their decision. A cross-sectional study was...

Globally, COVID-19 vaccines are currently being used to prevent transmission and reduce morbidity death associated with SARS-CoV-2 infection. Current research reveals that such as BNT162b2 Ad26.COV2.S highly immunogenic have high short-term effectiveness for most of the known viral variants. Clinical trials showed satisfying results in general population, but reluctance testing vaccinating pregnant women left this category little evidence regarding safety, efficacy, immunogenicity following...

Clinical trials for COVID-19 vaccines initially excluded pregnant women due to safety concerns, and when the were authorized emergency use, they not recommended this population. However, observational studies discovered that infected with have higher risks of negative pregnancy delivery outcomes compared non-pregnant women, raising question risks-benefits administering women. By mid-2021, there was general consensus on relative vaccination during pregnancy; therefore, it is critical...

In many countries, preterm birth, defined as birth before 37 completed weeks of gestation, is the primary cause infant death and morbidity. An increasing body research suggests that inflammation (both clinical subclinical) plays a significant role in inducing labor or developing pregnancy problems lead to premature birth. Consequently, purpose this was determine predictive value Neutrophil-Lymphocyte Ratio (NLR), derived (dNLR), Monocytes-to-Lymphocyte (MLR), Platelets-to-Lymphocyte (PLR),...

During the COVID-19 pandemic, it was observed that patients with heart disease are more likely to be hospitalized and develop severe COVID-19. Cardiac takes top position among patient comorbidities, failure (HF) prevalence reaching almost 5% in general population older than 35 years Romania. This retrospective study aimed determine potential use of NYHA classification for HF as prognostic tool in-hospital mortality, length hospitalization, probability rehospitalization decompensation. We...

SARS-CoV-2 infection produces alterations in blood clotting, especially severe cases of COVID-19. Abnormal coagulation parameters patients with COVID-19 are important prognostic factors disease severity. The objective this study was to evaluate the predictive value aPTT, D-dimer, INR and PT mortality A retrospective, single-center, observational conducted on admitted Municipal Emergency Clinical Hospital Timisoara, Romania, between August October 2021. Patients were confirmed as positive by...

Magnesium may contribute to the immune response during and after SARS-CoV-2 infection by acting as a cofactor for immunoglobulin production other processes required T B cell activity. Considering magnesium recommended dietary supplement pregnancy possible role of deficiency in COVID-19 its complications, current study sought determine effect magnesium-containing nutritional supplements on following pregnant women, well observe differences outcomes based taken pregnancy. The followed...

To date, the COVID-19 pandemic has caused millions of deaths across world. Prognostic scores can improve clinical management diagnosis and treatment. The objective this study was to assess predictive role 4C Mortality, CURB-65, NEWS in mortality among Romanian population. A single-center, retrospective, observational conducted on patients with reverse transcriptase-polymerase chain reaction (RT-PCR)-proven admitted Municipal Emergency Clinical Hospital Timisoara, Romania, between 1 October...

Postpartum depression is a major mental health disorder that can negatively affect both mother and baby. In addition, the COVID-19 pandemic associated with extreme measures of lockdown had profound effects on humanity, increasing rates anxiety depression, especially among women in postpartum period. The aim this study was threefold: to determine prevalence compare at two different times during pandemic, assess possible association between timing childbirth given period risk depression. A...

COVID-19 has been associated with cardiovascular consequences, including myocardial infarction, thromboembolic events, arrhythmia, and heart failure. Numerous overlapping mechanisms, such as the IL-6 dependent cytokine storm unopposed angiotensin II stimulation, could be responsible for these consequences. Cardiac damage is hypothesized to a consequence of direct viral infection cardiomyocytes, resulting in increased metabolic demand, immunological activation, microvascular dysfunction....

When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations initially adjourned, with late initiation for this populational category. The present study aims to quantify serum and breastmilk values of spike protein antibodies in both mother her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients included, some whom presented COVID-19 infection In delivery room, venous blood was collected...

(1) Background: This study evaluates the predictive effectiveness of biomarkers in diagnosing newborn sepsis. (2) Methods: was a case-control conducted on neonates hospitalized at Clinical Hospital "Louis Turcanu", Timisoara, Romania, from October 2018 to July 2023. Using vacutainer collection device, venous blood collected admission for complete tests, including ferritin, hemoglobin, LDH, and culture analysis. Neonates were divided into two groups: sepsis-positive sepsis-negative. The...

Cytomegalovirus (CMV) infection is the most common congenital worldwide, and remains a significant cause of neurological deficiency sensory deafness in developed countries. Maternal primary infection, reactivation or reinfection during pregnancy may lead to fetal CMV syndrome. The purpose this study was analyze seroprevalence according demographic features pregnant women western Romania as well evolution immunity two time intervals. IgG anti‑CMV antibodies were tested sera 8,951 successive...

We designed and implemented a prospective study to analyze the maternal neonatal outcomes associated with COVID-19 determine likelihood of viral transmission fetus newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, breast milk. The followed observational design, starting in July 2020 lasting for one year. A total 889 pregnant women were routinely tested SARS-CoV-2 infection an outpatient setting at our clinic, using nasal swabs PCR testing. 76 diagnosed...

Two years after the outbreak of COVID-19 pandemic, disease continues to claim victims worldwide. Assessing disease's severity on admission may be useful in reducing mortality among patients with COVID-19. The present study was designed assess prognostic value SOFA and qSOFA scoring systems for in-hospital included 133 proven by reverse transcriptase polymerase chain reaction (RT-PCR) admitted Municipal Emergency Clinical Hospital Timisoara, Romania between 1 October 2020 15 March 2021. Data...

Several investigations have revealed that COVID-19 causes a significant death rate due to acute respiratory distress syndrome, alterations in the quantity of ACE2 receptor expression, or intensity cytokine storm. Similarly, patients with hepatic impairment are co-infected SARS-CoV-2 more likely display upregulations receptors and storm overload, which exacerbates impairment, potentially increasing rate. Moreover, it is expected aging population develops higher degree fibrosis association...

Premature birth is a worldwide health issue, posing high mortality risk for newborns, as well causing emotional and financial difficulties, long-term issues patients. Identifying effective predictors preterm essential prolonging gestation or improving obstetric care. As invasive methods are costly, risky, not universally available, we aim to assess the predictive capacity of various serum parameters in pregnant women during third trimester, non-invasive alternative. Based on previous...

During the last decades, a growing number of studies have shown that infections during pregnancy an important impact on both pregnant women and their fetuses. Our goal was to identify newborns from pregnancies with SARS-CoV-2 infection investigate extension neonatal complications using cardiac, abdominal cerebral ultrasonography, hearing testing indirect ophthalmoscopy. By contrast, neonates whose mothers were vaccinated against COVID-19 those pathology-free been examined. A total 458...

Background: This study evaluates the role of D-dimer in identifying neonatal sepsis and their potential value clinical decision-making due to challenges early detection. Methodology: A case-control was conducted on 102 neonates at Children's Clinical Hospital "Louis Turcanu" Timisoara, Romania, from October 2018 July 2023. The participants were divided into two groups: those with without sepsis. Results: found that more likely be delivered by cesarean section had higher rates premature...

Toxoplasmosis is a zoonotic infection caused by the obligate intracellular apicomplexan parasite Toxoplasma gondii (T. gondii). T. cause of congenital worldwide. Primary or reactivation latent during pregnancy may lead to fetal and toxoplasmosis syndrome. Seropositive pregnant women are generally protected from maternal-fetal transmission gondii, although exceptions exist. The aim our study was analyze dynamics seroprevalence 10-year period correlate it with age demographic features women....

Widespread COVID-19 vaccination is crucial for limiting the spread of SARS-CoV-2 and minimizing risk novel variants arising in general population, especially pregnant women. According to publicly available research data, intentions vary significantly by country, with Romania among European countries lowest rates. Thus, we sought determine scale acceptance campaign women Romania, as well variables affecting their choices. A cross-sectional study was conducted on referred Obstetrics Gynecology...

(1) Background: This study aims to evaluate the association of CRP, NLR, IL-6, and Procalcitonin with lung damage observed on CT scans; (2) Methods: A cross-sectional was performed among 106 COVID-19 patients hospitalized in Timisoara Municipal Emergency Hospital. Chest laboratory analysis were all patients. The rank Spearmen correlation used assess between inflammatory markers involvement. In addition, ROC curve determine accuracy diagnosis severe damage; (3) Results: IL-6 significantly...

Background and Objectives: Toxoplasma gondii, cytomegalovirus (CMV) rubella virus, besides other agents, belong to a group named the TORCH complex. Research on epidemiology of these agents in women is particular interest, as primary infection during pregnancy could cause severe damage fetus. Women who had contracted before develop IgG antibodies, so fetus protected case contact with same agent. Our scope was identify childbearing simultaneously or susceptible two three mentioned above....

Studies observed that women infected with SARS-CoV-2 during pregnancy had a higher risk of preterm birth. Although it is likely COVID-19 the late trimester can trigger premature birth, prematurity remains concern, and vital to study additional clinical biological patient factors are highly associated this negative outcome allow for better management based on existing predictors. In order achieve goal, current retrospectively recruited 428 pregnant patients were separated into three groups...