A5019327453- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Zoonotic diseases and public health
- Virology and Viral Diseases
- Cytomegalovirus and herpesvirus research
- Animal Disease Management and Epidemiology
- Viral Infections and Outbreaks Research
- Malaria Research and Control
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Vector-Borne Animal Diseases
- Viral Infections and Immunology Research
- Vaccine Coverage and Hesitancy
- Animal Virus Infections Studies
- Pneumonia and Respiratory Infections
- Toxoplasma gondii Research Studies
University of Zagreb
2016-2025
Hrvatski zavod za javno zdravstvo
2016-2025
University of Pretoria
2022
Klinička bolnica Merkur
2019-2021
Polytechnic of Međimurje in Čakovec
2021
Ministry of Health
2017
National Institute of Public Health
2011
Women & Children's Hospital of Buffalo
2008
University at Buffalo, State University of New York
2008
After information about a dengue case in Germany acquired Croatia, health professionals and the public Croatia were alerted to assess situation enhance mosquito control, resulting diagnosis of second autochthonous fever same area detection 15 persons with evidence recent infection. Mosquito control measures introduced. The circumstances virus introduction remain unresolved.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and has since caused a global pandemic. Experimental studies sporadic reports have confirmed susceptibility of dogs cats to SARS-CoV-2 infection. However, the importance pet animals epidemiology this infection is unclear. This study on first large-scale serosurvey infections Europe. From 26 February 2020, just one day after human case Croatia, 15 June dog cat serum samples were collected from admitted three...
Tick-borne encephalitis (TBE) represents an important public health problem in Europe. We analyzed the epidemiology of TBE based on data from humans, animals, and Ixodes ricinus ticks endemic regions continental Croatia. In period 2017 to 2023, cerebrospinal fluid (CSF) serum samples 684 patients with neuroinvasive diseases, 2240 horse samples, 300 sheep were tested for TBEV. addition, 8751 I. collected. CSF using RT-PCR. Serological tests (serum, CSF) performed commercial ELISA,...
In 2018, Croatia reported the largest outbreak of West Nile virus (WNV) infections as well re-occurrence human Usutu (USUV) infections. For first time, fatal WNV and USUV were detected in wild birds. We analysed epidemiological characteristics molecular epidemiology during 2018 transmission season. From April to November, 178 patients with neuroinvasive disease 68 febrile tested for USUV. Viral RNA was cerebrospinal fluid (CSF) urine samples using a real-time RT-PCR. Positive by nested...
We report the first serological evidence of Usutu virus (USUV) infection in horses Croatia. During 2011, 1380 horse serum samples from healthy animals were collected six northern Croatian counties. All screened for West Nile (WNV) immunoglobulin G (IgG) antibodies using an enzyme-linked immunosorbent assay (ELISA). Sixty-nine WNV ELISA-reactive further tested by a neutralization (VN assay) and plaque reduction test (PRNT), USUV VN tick-borne encephalitis (TBEV) PRNT. same period, 306 human...
West Nile Virus Neuroinvasive Disease (WNV NID) requires prolonged intensive care treatment, resulting in high mortality and early disability. Long-term results are lacking. We have conducted an observational retrospective study with a prospective follow-up of WNV NID patients treated at the Intensive Care Unit (ICU), University Hospital for Infectious Diseases, Zagreb, Croatia, 2013-2018. Short-term outcomes were vital status, length stay (LOS), modified Rankin Scale (mRS), disposition...
Neuroinvasive flaviviruses such as tick-borne encephalitis virus (TBEV) and West Nile (WNV) are widely distributed in continental Croatian regions. We analyzed clinical characteristics, laboratory parameters, molecular epidemiology of neuroinvasive flavivirus infections eastern Croatia. A total 43 patients with confirmed infection hospitalized from 2017 to 2023 were included the study. Reverse-transcription polymerase chain reaction (RT-qPCR) was used detect RNA samples (cerebrospinal fluid;...
Autochthonous dengue cases have been continuously recorded in Europe the past two decades. The first autochthonous case Croatia was reported 2010 on Pelješac Peninsula, while imported were thereafter. In 2024, re-emerged Croatia. An epidemiological and entomological study conducted after receiving information virus (DENV) infection a German tourist probably acquired Dugi Otok Island May 2024. Serum samples collected from 30 residents of Veli Rat region where patient had stayed. addition,...
During 2005–2009, a seroepidemiological study was carried out in Croatia to define the population susceptible common TORCH agents among pregnant and non-pregnant women of childbearing age. The IgG seroprevalence 29.1% forT. gondii, 94.6% for rubella, 75.3% cytomegalovirus (CMV), 78.7% herpes simplex virus type 1 (HSV-1), 6.8% HSV-2. Acute toxoplasmosis CMV infection (positive IgM antibodies with low avidity) were documented 0.25% 0.09% women, respectively. prevalence 1.2% both HSV-1 None...
Toxoplasma gondii (TG), a zoonotic protozoan parasite, belongs to group of TORCH infectious agents, which can cause severe damage the fetus if primary infection occurs during pregnancy. After infection, TG rests lifelong in human organisms causing latent infection. Most studies have analyzed consequences acute, but not latent, This study impact toxoplasmosis on spontaneous abortion history, pregnancy complication rate and neonatal outcome.IgG IgM anti-TG antibodies were tested 806 pregnant...
Between September 6 and 21, 2012, seven human cases of West Nile virus (WNV) neuroinvasive infection were laboratory confirmed in Croatia. The median patient age was 62 years (range 48-77). Five patients presented with meningoencephalitis two followed by acute flaccid paralysis. Four them had an underlying disease (hypertension). Using enzyme-linked immunosorbent assay (ELISA), WNV-specific immunoglobulin M (IgM) IgG antibodies low avidity detected six patients, whereas one showed only IgM...
Data on the immune response to West Nile virus (WNV) are limited. We analyzed antiviral cytokine in serum and cerebrospinal fluid (CSF) samples of patients with WNV fever neuroinvasive disease using a multiplex bead-based assay for simultaneous quantification 13 human cytokines. The panel included cytokines associated innate early pro-inflammatory responses (TNF-α/IL-6), Th1 (IL-2/IFN-γ), Th2 (IL-4/IL-5/IL-9/IL-13), Th17 (IL-17A/IL-17F/IL-21/IL-22) key anti-inflammatory IL-10. Elevated...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel with pandemic spread. So far, total of 349,910 SARS-CoV-2 cases and 7687 deaths were reported in Croatia. We analyzed the seroprevalence neutralizing (NT) antibody response Croatian general population after first (May–July 2020) second (December 2020–February 2021) wave. Initial serological testing was performed using commercial ELISA, confirmation reactive samples by virus neutralization test (VNT). A significant...
Background and Objectives: Herpes simplex viruses (HSV-1 HSV-2) are one of the most widespread causes human viral infections. In Croatia, only two published studies have analyzed seroprevalence HSV infections in childbearing-aged pregnant women (2005–2010), while more recent data lacking. This study aimed to analyze prevalence risk factors for HSV-1 HSV-2 among Croatia period from 2011 2021. Materials Methods: included 667 aged 16–45 years submitted serology testing. Serum samples were...
Cytomegalovirus (CMV), a DNA virus that belongs to the Orthoherpesviridae family, infects 40–100% of people. Primary/non-primary CMV infection during pregnancy could cause fetal disabilities. After primary infection, causes latent and resides in cells myeloid compartment (CD34+, monocytes). Few studies have analyzed impact infections on miscarriage history, complications, neonatal outcomes. Methods: Serum samples from 806 pregnant women (28.29 ± 4.50 years old) who came for consultation at...