A5073893956- HIV Research and Treatment
- Hepatitis C virus research
- HIV-related health complications and treatments
- Mosquito-borne diseases and control
- HIV/AIDS drug development and treatment
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Research and Interventions
- Systemic Lupus Erythematosus Research
- Vector-borne infectious diseases
- Drug-Induced Adverse Reactions
- Hepatitis B Virus Studies
- Apelin-related biomedical research
- Syphilis Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Infectious Encephalopathies and Encephalitis
- Respiratory viral infections research
- Digital Imaging for Blood Diseases
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Diverse Scientific Research Studies
- Connective Tissue Growth Factor Research
- Immunodeficiency and Autoimmune Disorders
University Hospital for Infectious Diseases "Dr Fran Mihaljevic"
2012-2024
University Hospital Centre Zagreb
2014-2018
West Nile Virus Neuroinvasive Disease (WNV NID) requires prolonged intensive care treatment, resulting in high mortality and early disability. Long-term results are lacking. We have conducted an observational retrospective study with a prospective follow-up of WNV NID patients treated at the Intensive Care Unit (ICU), University Hospital for Infectious Diseases, Zagreb, Croatia, 2013-2018. Short-term outcomes were vital status, length stay (LOS), modified Rankin Scale (mRS), disposition...
Data on the immune response to West Nile virus (WNV) are limited. We analyzed antiviral cytokine in serum and cerebrospinal fluid (CSF) samples of patients with WNV fever neuroinvasive disease using a multiplex bead-based assay for simultaneous quantification 13 human cytokines. The panel included cytokines associated innate early pro-inflammatory responses (TNF-α/IL-6), Th1 (IL-2/IFN-γ), Th2 (IL-4/IL-5/IL-9/IL-13), Th17 (IL-17A/IL-17F/IL-21/IL-22) key anti-inflammatory IL-10. Elevated...
Tick-borne encephalitis virus (TBEV) is one of the most significant arboviruses affecting human central nervous system (CNS) in Europe. Data on cytokine response TBEV infection are limited.We analyzed serum, cerebrospinal fluid (CSF) and urine samples patients with TBE. The control group consisted 'febrile headache' who had normal CSF cytology. panel included 12 cytokines: TNF-α, IL-6, Th1 (IL-2, IFN-γ), Th2 (IL-4, IL-5, IL-13), Th9 (IL-9), Th17 (IL-17A, IL-17F), Th22 (IL-22) cytokines...
Toscana virus (TOSV) is an arthropod-borne virus, transmitted to humans by phlebotomine sandflies. Although the majority of infections are asymptomatic, neuroinvasive disease may occur. We report three cases TOSV infection detected in Croatia. Two patients aged 21 and 54 years presented with meningitis, while a 22-year old patient meningoencephalitis right-sided brachial plexitis. Cerebrospinal fluid (CSF), serum, urine samples were collected tested for arboviruses: tick-borne encephalitis,...
The aim of this study was to analyze the predictive value CXCL9, CXCL10, and CXCL11 concentrations before after 4 12 weeks treatment with pegylated interferon-α2b ribavirin in patients chronic hepatitis C infected virus genotype 1. included 46 adult (29 women 17 men). Chemokine quantification serum performed at baseline 1, 3, 6 months by enzyme immunoassay. responses were compared achieving a sustained virological response (SVR, n=26) non-SVR group (n=20). differences CXCL9 CXCL10 between...
Semaphorins are a diverse family of immunoregulators recently recognized to play major role in various phases immune responses. Their chronic viral hepatitis C (CHC) and contribution the progression liver disease is unknown. The aim this study was analyse association secreted semaphorins with severity patients CHC. Serum concentrations were measured 114 treatment-naive CHC 36 healthy controls. SEMA3A, SEMA3C, SEMA5A, SEMA6B SEMA6D significantly increased compared While serum SEMA3C fibrosis...
Introduction Successfully treated HIV‐infected patients may still have an increased risk for cardiovascular morbidity and mortality, which might be related not only to traditional risks, but also inflammation dyslipidemia induced by HIV and/or antiretroviral therapy [ 1 , 2 ]. We examined the relationship of serum lipid levels with plasma biomarkers using a composite inflammatory burden score (IBS) from following seven markers inflammation: CD40L, tPA, MCP‐1, IL‐8, IL‐6, hCRP P‐selectin....
Tick-borne encephalitis virus (TBEV) and West Nile (WNV) are the most important neuroinvasive arboviruses detected in Europe. In this study, we analyzed cerebrospinal fluid (CSF) concentrations of 12 proinflammatory chemokines (CCL2, CCL3, CCL4, CCL11, CCL17, CCL20, CXCL1, CXCL5, CXCL8, CXCL9, CXCL10, CXCL11) 77 patients with diseases (NIDs). Flavivirus infection was confirmed 62 (TBEV WNV 31 each), while 15 etiology NID not determined (NDE). Similar patterns high-level expression regulating...
Cytokines are biological response modifiers involved in the pathophysiology of chronic obstructive pulmonary disease (COPD). This study investigated potential use cytokines as severity biomarkers COPD patients and possible effect statin therapy on cytokine expression. Possible associations between cytokines, body mass index (BMI) smoking have also been studied. IFN-γ, IL-2, IL-12 p70, TNF-α, TNF-β, IL-4, IL-5, IL-6, IL-10, IL-1β IL-8 were measured plasma 100 clinically stable using a...
Background: Therapy for chronic hepatitis C is based on direct-acting antiviral drugs (DAA) that include protease inhibitors, polymerase as well inhibitors of NS5A protein. Resistance-associated substitutions (RAS) can be associated with inadequate treatment outcomes DAA. People HCV subtype 1a infection carrying Q80K polymorphism could have a reduced response to inhibitor simeprevir. The data the prevalence and other RAS worldwide are quite variable. Objectives: study goal was analyze...
Background and Objectives: The aim of this study was to analyze the expression genes on transcriptomic levels involved in inflammatory immune responses development fibrosis patients with chronic hepatitis C. Materials Methods: Expression patterns 84 selected were analyzed real-time quantitative RT PCR arrays peripheral blood treatment-naive C healthy controls. panel included pro- anti-fibrotic genes, coding for extracellular matrix (EMC) structural constituents remodeling enzymes, cell...
Approximately 257 million people worldwide live with chronic hepatitis B virus (HBV) infection, which, if left untreated, can lead to liver cirrhosis or hepatocellular carcinoma. The is a DNA reverse transcriptase that has no exonuclease activity, which results in high mutation rate. Reverse inhibitors, interfere viral replication, are used treat the infection. Mutations A-B interdomain be associated resistance antiviral drugs, as well immune escape. aim of this study was analyze HBV...
Croatia is a small southeastern European country with low prevalence of HIV infection and centralized system clinical care. The cumulative number infections in the period 1985-2013 was 1,102. aim this study to analyze distribution HIV-1 subtypes Croatia. The enrolled 356 HIV-infected patients (86.2% males) receiving care at Croatian Reference Center for HIV/AIDS 2000-2013. were classified into three groups based on year genotyping entrance (2000-2005, 2006-2010 2011-2013)....