A5005450617- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Drug-Induced Adverse Reactions
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Actinomycetales infections and treatment
- Vector-Borne Animal Diseases
- Parvovirus B19 Infection Studies
- Blood disorders and treatments
- Liver Diseases and Immunity
- Parasitic infections in humans and animals
- Cardiac tumors and thrombi
- Microbial infections and disease research
- Bacillus and Francisella bacterial research
- Legionella and Acanthamoeba research
- Cardiac Structural Anomalies and Repair
- Hepatitis Viruses Studies and Epidemiology
- Synthesis and properties of polymers
- SARS-CoV-2 and COVID-19 Research
- Parasitic Infections and Diagnostics
- Ear and Head Tumors
Klinički Bolnički Centar Rijeka
2009-2023
University of Rijeka
2008-2023
Human cytomegalovirus (HCMV) is the most frequent cause of congenital viral infections in humans and frequently leads to long-term central nervous system (CNS) abnormalities that include learning disabilities, microcephaly, hearing loss. The pathogenesis CNS infection has not been fully elucidated may arise as a result direct damage CMV-infected neurons or indirectly secondary inflammatory response infection. We used recently established model mouse CMV (MCMV) newborn mice analyze...
Human CMV (HCMV) is a major cause of morbidity and mortality in both congenitally infected immunocompromised individuals. Development an effective HCMV vaccine would help protect these vulnerable groups. NK group 2, member D (NKG2D) potent activating receptor expressed by cells the innate adaptive immune systems. Its importance surveillance indicated elaborative evasion mechanisms evolved virus to avoid NKG2D. In order study this signaling pathway, we engineered recombinant mouse expressing...
Toscana virus (TOSV) is an arthropod-borne virus, transmitted to humans by phlebotomine sandflies. Although the majority of infections are asymptomatic, neuroinvasive disease may occur. We report three cases TOSV infection detected in Croatia. Two patients aged 21 and 54 years presented with meningitis, while a 22-year old patient meningoencephalitis right-sided brachial plexitis. Cerebrospinal fluid (CSF), serum, urine samples were collected tested for arboviruses: tick-borne encephalitis,...
Hantaviruses remain an important case of emerging and re-emerging infections in human medicine. This study aimed to analyse the epidemiology, clinical presentation, outcome hantavirus western part Republic Croatia, a new geographical area for infections.Retrospective analysis medical records patients treated hemorrhagic fever with renal syndrome (HFRS) at infectious diseases Clinic Clinical Hospital Center Rijeka, from 1 January 2014, 31 December 2021.During eight-year period, 251 were...
Virus krpeljnog meningoencefalitisa (KME) najčešći je uzročnik infekcija središnjeg živčanog sustava u endemskim područjima srednje Europe. Radi se o prirodno žarišnoj zoonozi, čiji rezervoar čine šumski glodavci, domaće i divlje životinje, a čovjek zarazi prigodno, ubodom inficiranog krpelja. U posljednje vrijeme sve više izvješća epidemijama KME povezanih s konzumacijom svježeg mlijeka mliječnih proizvoda. Cilj rada prikazati kliničke značajke tijek bolesti kod oboljelih od tijeku...
Bolest mačjeg ogreba (BMO) infekcija je uzrokovana Gram negativnom, fakultativno intracelularnom bakterijom Bartonella henselae. Glavni rezervoar infekcije mačka i oko 75% bolesnika ima podatak o ogrebu ili ugrizu mačke u anamnezi. Rjeđe se javlja kontaktu s psom, posredovano mačjom buhom neizravnim kontaktom oštećene kože sluznice površinom kontaminiranom slinom. Infekcija može proći asimptomatski, ali prezentirati spektrom kliničkih manifestacija. U 85-90 % radi klasičnoj BMO kožnom...
Cilj : Incidencija hepatitisa A u našoj zemlji, slično ostalim razvijenim zemljama, niska je zahvaljujući poboljšanju socioekonomskog standarda i higijenskih uvjeta. U zemljama svijeta posljednje desetljeće opisane su epidemije vezane uz „novi”, spolni put prijenosa, poglavito MSM populaciji (engl. Men Sex ; MSM) osoba s drugim spolno prenosivim infekcijama. Budući da od češće obolijevaju osobe odrasle dobi, učestalost komplikacija veća odnosu na nerazvijene zemlje gdje hepatitis bolest...