A5058021268- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Apelin-related biomedical research
- Hepatitis Viruses Studies and Epidemiology
- Sperm and Testicular Function
- Axon Guidance and Neuronal Signaling
- Liver Disease and Transplantation
- Clostridium difficile and Clostridium perfringens research
- Parasitic infections in humans and animals
- Reproductive Biology and Fertility
- Viral Infections and Vectors
- Congenital Anomalies and Fetal Surgery
- Long-Term Effects of COVID-19
- Neonatal and Maternal Infections
- Nosocomial Infections in ICU
- Mechanical Circulatory Support Devices
- Liver Diseases and Immunity
- Reproductive tract infections research
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Sepsis Diagnosis and Treatment
- Viral Infections and Outbreaks Research
University Hospital for Infectious Diseases "Dr Fran Mihaljevic"
2013-2025
University Hospital Centre Zagreb
2014-2025
University of Zagreb
2018-2025
European Society of Clinical Microbiology and Infectious Diseases
2018
University of Utah
2012-2013
Huazhong University of Science and Technology
2013
Tongji Hospital
2013
University Hospital Dubrava
2010
HUN-REN Institute for Nuclear Research
1995
Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease. Liver inflammation underlies infection-induced fibrosis, cirrhosis and cancer but the processes that promote hepatic by HCV are not defined. We provide systems biology analysis with multiple lines evidence to indicate interleukin-1β (IL-1β) production intrahepatic macrophages confers through HCV-induced inflammasome signaling. patients exhibited elevated levels serum IL-1β compared healthy controls....
Background/Objectives: While the concept of viral community-acquired pneumonia (CAP) changed with COVID-19, role non-influenza viruses as a cause CAP is less clear. The aim this study was to describe clinical course, risk factors, inflammatory profiles, antibiotic use, outcomes and complications adenoviral (AdV) CAP. Methods: A prospective, non-interventional, observational cohort included consecutively hospitalized immunocompetent adult patients AdV during an 18-month period. Clinical...
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is the most common associated with systemic changes in immune response, which might be coronavirus 2019 (COVID-19) severity. The aim of this study was to investigate impact NAFLD on COVID-19 severity and outcomes. Methods A prospective observational included consecutively hospitalized adult patients, between March June 2021, severe COVID-19. Patients were screened for by ultrasound subsequently diagnosed NAFLD. daily followed until...
Please cite this paper as: Papic et al. (2011) Liver involvement during influenza infection: perspective on the 2009 pandemic. Influenza and Other Respiratory Viruses 6(3), e2–e5. Elevation of liver transaminase levels is a frequent observation systemic infections. The aim our study was to investigate damage pandemic A/H1N1 infection in comparison with seasonal influenza. Serum aspartate aminotransferase, alanine gamma‐glutamyl transpeptidase (GGT) were significantly higher patients compared...
West Nile Virus Neuroinvasive Disease (WNV NID) requires prolonged intensive care treatment, resulting in high mortality and early disability. Long-term results are lacking. We have conducted an observational retrospective study with a prospective follow-up of WNV NID patients treated at the Intensive Care Unit (ICU), University Hospital for Infectious Diseases, Zagreb, Croatia, 2013-2018. Short-term outcomes were vital status, length stay (LOS), modified Rankin Scale (mRS), disposition...
Background: While it has been shown that steatotic liver disease (SLD) is associated with systemic changes in immune response, the impact of SLD on sepsis outcomes not yet established. The aim this study was to investigate association between and severity outcomes. Methods: A prospective observational included consecutively hospitalized adult patients community-acquired during a 16-month period. Results: Of 378 (49.5% male, median age 69, IQR 57–78 years), 174 (46%) were diagnosed SLD....
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been identified as a risk factor for severe community-acquired pneumonia (sCAP) outcomes. While MASLD is associated with chronic systemic inflammation, cytokine responses in patients sCAP and have not characterized. The aim of this study was to analyze differences concentrations kinetics cytokines without MASLD. Methods A prospective cohort pilot included hospitalized defined according IDSA...
Abstract Background Community-acquired pneumonia (CAP) is one of the leading causes morbidity and mortality. While metabolic syndrome has been identified as a risk factor for CAP outcomes, role dysfunction-associated steatotic liver disease (MASLD) in less clear. This study aimed to investigate prevalence severity MASLD hospitalized patients with CAP. Prevalence community-acquired Methods A prospective observational cohort (SepsisFAT) included adult at three clinical departments University...
The tapeworms Echinococcus granulosus and multilocularis cause two different clinical manifestations in humans: cystic echinococcosis (CE) alveolar (AE), respectively. Both forms of manifest primarily the liver, while other organs or tissues are less frequently affected. Simultaneous occurrence CE AE is extremely rare all previously reported patients had affected simultaneous infection without liver involvement has not yet been described. Hereby, we present an exclusively extrahepatal E....
Metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been linked with sepsis outcomes. However, the immune mechanisms by which MASLD aggravates severity are unknown. This prospective cohort study aimed to analyze serum cytokine and chemokine kinetics in patients community-acquired sepsis. Out of 124 patients, 68 (55%) were diagnosed MASLD. There no differences age, sex, comorbidities, baseline severity, or etiology between groups. Serum concentrations 27 cytokines...
The tapeworms Echinococcus granulosus and multilocularis cause two different clinical manifestations in humans: cystic echinococcosis (CE) alveolar (AE), respectively. Both forms of manifest primarily the liver, while other organs or tissues are less frequently affected. Simultaneous occurrence CE AE is extremely rare, all previously reported patients exhibited affected livers, simultaneous infection without liver involvement has not yet been described. Herein, we present an exclusively...
We describe the first report of RNA sequencing 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes participate in viral-host interactions. identified 100, 684, 1,844 significantly proliferative at 6, 48, 72 hours, respectively (fold change ≥ 1.5 Bonferroni adjusted p-values < 0.05). Most (>80%) biological pathways (such as adipocytokine,...
Human alveolar echinococcosis (HAE), caused by the metacestode stage of Echinococcus multilocularis, has emerged in many European countries over last two decades. Here, we report first data on new HAE focus with increasing incidence central Croatia, describe its clinical presentation and outcomes diagnosed patients, provide an update prevalence geographic distribution multilocuaris red foxes. After initial case 2017 from eastern state border, 2019 to 2022, five autochthonous cases were...
Alveolar echinococcosis is a parasitic disease caused by the tapeworm larval stage of Echinococcus multilocularis. This zoonotic has not been known to occur in Croatia. We report confirmed case human alveolar patient Croatia who had never visited E. multilocularis-endemic area.
Non-alcoholic fatty liver disease (NAFLD) is identified as a risk factor for developing severe COVID-19. While NAFLD associated with chronic low-grade inflammation, mechanisms leading to immune system hyperactivation remain unclear. The aim of this prospective observational study analyze cytokine profiles in patients COVID-19 and NAFLD. A total 94 were included. Upon admission, clinical laboratory data collected, ultrasound was performed determine the presence steatosis, subsequently, 51...
The incidence of complication rates in patients treated with venovenous extracorporeal membrane oxygenation (VV ECMO) remains substantial and impacts the results any future trial dealing ECMO efficacy. Of these complications blood stream infections (BSI) are less well studied. Our objective was to report influence BSI ARDS VV ECMO.One-hundred adult at tertiary care hospital Zagreb, Croatia between October 2009 June 2016 were prospectively included study.In 35% an episode nosocomial during...
Healthcare associated meningitis and ventriculitis (HCAMV) are serious complications of neurosurgical procedures. We conducted a retrospective cohort study patients with HCAMV treated at the University Hospital for Infectious Diseases Zagreb during 2013-2019 period. A total 144 151 episodes were included. The most common indications procedures brain tumor, hemorrhage hydrocephalus. Etiology was identified in 90 (59.6%) (either positive CSF culture or PCR), other 61 (40.39%) diagnosis made...
Community-acquired pneumonia (CAP) is one of the leading causes morbidity and mortality, while nonalcoholic fatty liver disease (NAFLD) most common cause chronic disease. NAFLD associated with systemic changes in immune response, possibly linked to CAP severity. However, impact on outcomes has not been determined. The aim this study was evaluate clinical course, complications severe requiring ICU treatment patients pre-COVID-19 era. A retrospective cohort included 138 consecutively...
Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic in Western countries, has been identified as a possible risk factor for COVID-19 severity. However, immunological mechanisms by which NAFLD exacerbates remain unknown. Transforming growth factor-beta 1 (TGF-β1) an important immunomodulatory and pro-fibrotic role, already described NAFLD. role TGF-β1 remains unclear, could also be pathophysiology link between these two conditions. The aim this case–control study was to...
Recurrent Clostridioides difficile infections (rCDI) have a substantial impact on healthcare systems, with limited and often expensive therapeutic options. Nonalcoholic fatty liver disease (NAFLD) affects about 25% of the adult population is associated metabolic syndrome, changes in gut microbiome bile acids biosynthesis, all possibly related rCDI. The aim this study was to determine whether NAFLD risk factor A retrospective cohort included patients ≥ 60 years hospitalized CDI. divided into...
The aim of this study was to analyze the predictive value CXCL9, CXCL10, and CXCL11 concentrations before after 4 12 weeks treatment with pegylated interferon-α2b ribavirin in patients chronic hepatitis C infected virus genotype 1. included 46 adult (29 women 17 men). Chemokine quantification serum performed at baseline 1, 3, 6 months by enzyme immunoassay. responses were compared achieving a sustained virological response (SVR, n=26) non-SVR group (n=20). differences CXCL9 CXCL10 between...