(1) Background: Since its discovery, COVID-19 has caused more than 256 million cases, with a cumulative death toll of 5.1 million, worldwide. Early identification patients at high risk mortality is great importance in saving the lives patients. The study aims to assess utility various inflammatory markers predicting among hospitalized COVID-19. (2) Methods: A retrospective observational was conducted 108 laboratory-confirmed between 1 May 2021 and 31 October Municipal Emergency Clinical...

Universal COVID-19 immunization is seen as a critical approach for limiting the spread of SARS-CoV-2 and reducing danger new variations emerging in general population, especially pregnant women. The literature accessible research data indicate that vaccination intentions vary greatly by country, with Romania ranking among European nations lowest rates. Thus, we aimed to investigate prevalence extent vaccine hesitancy women factors influencing their decision. A cross-sectional study was...

The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely the recent years due to multiple applications these nanomaterials, mainly domains like cancer. aim present study was: (i) develop biocompatible colloidal suspensions based on as future theranostic tools for skin pathology and (ii) test their effects vitro human keratinocytes (HaCat cells) vivo by employing an animal model acute dermal toxicity. Biocompatible were obtained coating resulted during solution...

Globally, COVID-19 vaccines are currently being used to prevent transmission and reduce morbidity death associated with SARS-CoV-2 infection. Current research reveals that such as BNT162b2 Ad26.COV2.S highly immunogenic have high short-term effectiveness for most of the known viral variants. Clinical trials showed satisfying results in general population, but reluctance testing vaccinating pregnant women left this category little evidence regarding safety, efficacy, immunogenicity following...

Clinical trials for COVID-19 vaccines initially excluded pregnant women due to safety concerns, and when the were authorized emergency use, they not recommended this population. However, observational studies discovered that infected with have higher risks of negative pregnancy delivery outcomes compared non-pregnant women, raising question risks-benefits administering women. By mid-2021, there was general consensus on relative vaccination during pregnancy; therefore, it is critical...

In many countries, preterm birth, defined as birth before 37 completed weeks of gestation, is the primary cause infant death and morbidity. An increasing body research suggests that inflammation (both clinical subclinical) plays a significant role in inducing labor or developing pregnancy problems lead to premature birth. Consequently, purpose this was determine predictive value Neutrophil-Lymphocyte Ratio (NLR), derived (dNLR), Monocytes-to-Lymphocyte (MLR), Platelets-to-Lymphocyte (PLR),...

This study conducted a detailed analysis of the vaginal microbiota in pregnant women to explore its correlation with preterm birth (PTB) outcomes. The primary objective was identify microbial variations associated increased PTB risk. Secondary objectives included investigating how changes composition relate local immune environment and PTB. Utilizing retrospective case–control design, involved liveborn infants between 2019 2023. In total, 89 who delivered 106 term deliveries were included....

During the COVID-19 pandemic, it was observed that patients with heart disease are more likely to be hospitalized and develop severe COVID-19. Cardiac takes top position among patient comorbidities, failure (HF) prevalence reaching almost 5% in general population older than 35 years Romania. This retrospective study aimed determine potential use of NYHA classification for HF as prognostic tool in-hospital mortality, length hospitalization, probability rehospitalization decompensation. We...

SARS-CoV-2 infection produces alterations in blood clotting, especially severe cases of COVID-19. Abnormal coagulation parameters patients with COVID-19 are important prognostic factors disease severity. The objective this study was to evaluate the predictive value aPTT, D-dimer, INR and PT mortality A retrospective, single-center, observational conducted on admitted Municipal Emergency Clinical Hospital Timisoara, Romania, between August October 2021. Patients were confirmed as positive by...

Magnesium may contribute to the immune response during and after SARS-CoV-2 infection by acting as a cofactor for immunoglobulin production other processes required T B cell activity. Considering magnesium recommended dietary supplement pregnancy possible role of deficiency in COVID-19 its complications, current study sought determine effect magnesium-containing nutritional supplements on following pregnant women, well observe differences outcomes based taken pregnancy. The followed...

To date, the COVID-19 pandemic has caused millions of deaths across world. Prognostic scores can improve clinical management diagnosis and treatment. The objective this study was to assess predictive role 4C Mortality, CURB-65, NEWS in mortality among Romanian population. A single-center, retrospective, observational conducted on patients with reverse transcriptase-polymerase chain reaction (RT-PCR)-proven admitted Municipal Emergency Clinical Hospital Timisoara, Romania, between 1 October...

The multiplex PCR is a powerful and efficient tool that was widely used during the COVID-19 pandemic to diagnose SARS-CoV-2 infections has applications for bacterial identification, as well determining resistance antibiotics. Therefore, this study aimed determine usability of PCR, especially in patients self-medicated with antibiotics, where cultures often give false-negative results. A cross-sectional developed two units, 489 eligible were included antibiotic takers non-antibiotic takers....

Background/Objectives: Breast cancer remains a leading cause of cancer-related morbidity worldwide, and refining prognostic tools is essential for individualized patient management. Recent evidence suggests that the systemic immune–inflammation index (SII), derived from routine blood tests, may offer valuable insights. This study aimed to evaluate whether SII can reliably predict clinical outcomes patients undergoing curative resection. Methods: We retrospectively analyzed with...

Patent ductus arteriosus (PDA) is common in newborns, being associated with high morbidity and mortality. While maternal neonatal conditions are known contributors, few studies use advanced machine learning (ML) as predictive factors. This study assessed how pathologies, medications, factors affect the risk of PDA using traditional statistics ML algorithms: Random Forest (RF) XGBoost (XGB). A retrospective 3 year cohort 201 NICU neonates Logistic regression (LR) chi-square analyses...

Background and Objectives: Patent ductus arteriosus (PDA) is common in newborns, being associated with high morbidity mortality. While maternal neonatal conditions are known contributors, few studies use advanced machine learning (ML) as predictive factors. This study assessed how pathologies, medications, factors affect the risk of PDA using traditional statistics ML algorithms: Random Forest (RF) XGBoost (XGB). Materials Methods: A retrospective 3-year cohort 201 NICU neonates Logistic...

Purpose: To evaluate the prevalence of depression and its impact on quality diabetes-related self-care activities in elderly patients with type 2 diabetes. Patients methods: In this cross-sectional study, 184 diabetes were enrolled. Depression was evaluated using Patient Health Questionnaire-9 while assessed Summary Diabetes-Related Self Care Activities Questionnaire. Results: our study group, 53.3% had moderate depression, 17.9% severe 28.8% no symptoms. Patient’s age ( P =0.024), presence...

Postpartum depression is a major mental health disorder that can negatively affect both mother and baby. In addition, the COVID-19 pandemic associated with extreme measures of lockdown had profound effects on humanity, increasing rates anxiety depression, especially among women in postpartum period. The aim this study was threefold: to determine prevalence compare at two different times during pandemic, assess possible association between timing childbirth given period risk depression. A...

Preeclampsia is a pregnancy-specific illness that hypothesized to occur due vitamin D deficiency during pregnancy. Therefore, supplementation in early pregnancy should be explored for preventing preeclampsia and promoting neonatal well-being. The present study follows case-control analysis aims determine the effect of supplements on reducing probability recurrent preeclampsia. We identified 59 patients control group without pregnancy, while 139 were included cases pregnant women with history...

Anemia is a very common occurrence during pregnancy, with important variations each trimester. was also considered as risk factor for severity and negative outcomes in patients SARS-CoV-2 infection. As the COVID-19 pandemic poses significant threat pregnant women terms of infection access to care, we developed study determine impact nutritional supplementation iron deficiency anemia correlation status In case-control design, identified 446 pregnancies that matched our inclusion criteria from...

Patients with cirrhosis are known to have multiple comorbidities and impaired organ system functioning due alterations caused by chronic liver failure. In the past two years, since COVID-19 pandemic started, several studies described affinity of SARS-CoV-2 biliary cells. Considering hepatitis C as a significant independent factor for in Romania, this research was built on premises that certain group patients is susceptible their serum parameters yet be described, which might useful...

Many elderly patients with severe SARS-CoV-2 infections and COVID-19 are admitted to intensive care units. Age was previously identified as an independent risk factor for death contributed the greater severity of COVID-19. The may have diminished lung functions, poor reactions artificial ventilation, compromised immune systems. However, it is yet uncertain how each pandemic wave predominant strains contribute varying results patient groups such impacted. Comparing six waves, objective this...

COVID-19 has been associated with cardiovascular consequences, including myocardial infarction, thromboembolic events, arrhythmia, and heart failure. Numerous overlapping mechanisms, such as the IL-6 dependent cytokine storm unopposed angiotensin II stimulation, could be responsible for these consequences. Cardiac damage is hypothesized to a consequence of direct viral infection cardiomyocytes, resulting in increased metabolic demand, immunological activation, microvascular dysfunction....

When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations initially adjourned, with late initiation for this populational category. The present study aims to quantify serum and breastmilk values of spike protein antibodies in both mother her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients included, some whom presented COVID-19 infection In delivery room, venous blood was collected...

(1) Background: This study evaluates the predictive effectiveness of biomarkers in diagnosing newborn sepsis. (2) Methods: was a case-control conducted on neonates hospitalized at Clinical Hospital "Louis Turcanu", Timisoara, Romania, from October 2018 to July 2023. Using vacutainer collection device, venous blood collected admission for complete tests, including ferritin, hemoglobin, LDH, and culture analysis. Neonates were divided into two groups: sepsis-positive sepsis-negative. The...