A5008619582- Pelvic floor disorders treatments
- Cervical Cancer and HPV Research
- Hernia repair and management
- Cancer Cells and Metastasis
- Endometrial and Cervical Cancer Treatments
- Reproductive Health and Technologies
- Adolescent and Pediatric Healthcare
- Family and Disability Support Research
- Assisted Reproductive Technology and Twin Pregnancy
- Dental Erosion and Treatment
- Cystic Fibrosis Research Advances
- Pelvic and Acetabular Injuries
- Laser Applications in Dentistry and Medicine
- Neurological disorders and treatments
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Anorectal Disease Treatments and Outcomes
- Cardiac pacing and defibrillation studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Dental materials and restorations
- Uterine Myomas and Treatments
- Wnt/β-catenin signaling in development and cancer
- Histone Deacetylase Inhibitors Research
Victor Babeș University of Medicine and Pharmacy Timișoara
2015-2025
Universal COVID-19 immunization is seen as a critical approach for limiting the spread of SARS-CoV-2 and reducing danger new variations emerging in general population, especially pregnant women. The literature accessible research data indicate that vaccination intentions vary greatly by country, with Romania ranking among European nations lowest rates. Thus, we aimed to investigate prevalence extent vaccine hesitancy women factors influencing their decision. A cross-sectional study was...
Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality with infection by human papilloma virus (HPV) being the most important risk factor. We analysed association between different viral integration signatures, clinical parameters and outcome in pre-treated CCs. Different signatures were identified using HPV double capture followed next-generation sequencing (NGS) 272 CC patients from BioRAIDs study [NCT02428842]. Correlations clinical, biological molecular...
There is a lack of information as to which molecular processes, present at diagnosis, favor tumour escape from standard-of-care treatments in cervical cancer (CC). RAIDs consortium (www.raids-fp7.eu), conducted prospectively monitored trial, [BioRAIDs (NCT02428842)] with the objectives generate high quality samples and assessments stratify patient populations identify patterns associated poor outcome.Between 2013 2017, collected prospective CC sample clinical dataset involving 419...
Magnesium may contribute to the immune response during and after SARS-CoV-2 infection by acting as a cofactor for immunoglobulin production other processes required T B cell activity. Considering magnesium recommended dietary supplement pregnancy possible role of deficiency in COVID-19 its complications, current study sought determine effect magnesium-containing nutritional supplements on following pregnant women, well observe differences outcomes based taken pregnancy. The followed...
Objectives: Pelvic organ prolapse (POP) is a common condition affecting women, often requiring surgical intervention. Laparoscopic pectopexy has gained popularity, but there ongoing debate about the efficacy and safety of mesh versus thread as fixation materials. This study aims to compare outcomes these two techniques, focusing on cure, recurrence postoperative complication rates. Methods: A prospective analysis was conducted patients undergoing laparoscopic for POP. included 78 diagnosed...
Background: One of the parameters maximum interest regarding quality intraoral hard tissues is represented by bone density, with direct clinical implications. The evaluation this extremely important parameter can be achieved several imaging methods, which most known in dentistry cone beam computed tomography (CBCT). Objectives: purpose study to obtain a quantitative analysis mineral density changes patients who underwent treatments photobiomodulation (PBM), as complementary surgical approach...
Around 20% of couples worldwide are affected by infertility issues, with numbers in the European Union reaching as high 25%, while access to reproductive care varies significantly geopolitical and country-specific variables. The purpose this research is shed light on unique social, psychological, financial difficulties faced Romanian seeking assisted therapy (ART). A cross-sectional study was conducted between 2017 2019 involve women who accessed ART at fertility clinics Romania completing...
Background: Tertiary lymphoid structures (TLSs) mediate local antitumor immunity, and interest in them significantly increased since cancer immunotherapy was implemented. We examined TLS− tumor stromal blood vessel interplay for each breast (BC) molecular subtype related to recurrence, lymphovascular invasion (LVI), perineural (PnI). Methods: TLSs were quantified on hematoxylin eosin stain specimens followed by CD34/smooth muscle actin (SMA) double immunostaining maturation assessment....
Objective: This study aims to provide an in-depth analysis of patient preferences and clinical outcomes associated with two prominent surgical techniques for treating Stress Urinary Incontinence (SUI): the modified laparoscopic Burch colposuspension transobturator tape (TOT) procedure. Material Methods: A prospective cohort was conducted on 145 patients who recieved treatment SUI, which 71 (49%) underwent procedure, while 74 (51%) received TOT Data characteristics, success rates,...
Chronic venous disease (CVD) represents a significant health challenge, particularly in obese individuals. This study focuses on the interplay between inflammation, obesity, and CVD, by analyzing role of inflammatory markers progression.
Coronavirus disease is a global pandemic with millions of confirmed cases and hundreds thousands deaths worldwide that continues to create significant burden on the healthcare systems. The aim this study was determine patient clinical paraclinical profiles associate COVID-19 unfavourable outcome generate prediction model could separate between high-risk low-risk groups.The present multivariate observational retrospective study. A total 483 patients, residents municipality Timișoara, biggest...
Aim: The purpose of this study is to evaluate the remineralization potential primary teeth enamel after being exposed different laser diode therapy. Methods: Ninety-six vestibular samples were divided into eight groups (n=12) with varying treatments: control (G1), CPP-ACP-fluoride varnish (G2), lasers at 980 nm (G3), 808 (G4), 450 (G5), + (G6), (G7), and (G8). Each sample was assessed using DIAGNOdent® baseline, post-treatment, post-pH cycle re-mineralization. SEM imaging performed before...
Objectives: The purpose of this study is to evaluate the remineralization potential primary teeth enamel after being exposed different laser diode therapies. Methods: Ninety-six vestibular samples were divided into eight groups (n = 12) with varying treatments: control (G1), CPP-ACP-fluoride varnish (G2), lasers at 980 nm (G3), 808 (G4), 450 (G5), + (G6), (G7), and (G8). Each sample was assessed using a DIAGNOdent® (KaVo Dental, Biberach, Germany), baseline, post-treatment, post-pH cycle...
Background and Objectives: On 24 March 2020, the United States Food Drug Administration (FDA) announced approval of convalescent plasma therapy for critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an emergency investigational new drug. This pilot study from Romania aimed to determine if transfusion can be beneficial in treatment selected diagnosed a SARS-CoV-2 infection. Materials Methods: Donor receiver eligibility disease 2019 (COVID-19) was...
Objectives: To compare the follow-up results of a sacrospinous ligament fixation (SSLF) technique for laparoscopic bilateral vagina to iliopectineal via PVDF-mesh (laparoscopic pectopexy technique, LP) in terms cure rate and postoperative complications rate. Material methods: This prospective study included 160 patients diagnosed with pelvic organ prolapse stage II–IV according POP-Q system. Eighty-two (51.25%) underwent vaginal seventy-eight (48.75%) procedure. Results: The was high both...
The COVID-19 pandemic has severely impacted healthcare workers, a professional category at risk of infection in both hospital and community settings. aim the study was to compare morbidity among staff that general population, as well factors predicting non-vaccination reinfection.The present is retrospective, cross-sectional study. It conducted by including all confirmed cases medical members during period 01.01.2021-31.03.2022 were reported Public Health Authority Timis County, Timisoara,...
Maternal hormones are essential for the normal fetal development during pregnancy. Autoimmune thyroid disease is a frequent pathology in our iodine replete region. The aim of this study to evaluate occurrence subclinical hypothyroidism (SCH) cases with known autoimmune disease, which were euthyroid state prior pregnancy, and assess association between supplemental treatments administered outcome prospective interventional controlled study. two cohorts comprise group, consisting 109 pregnant...
E- and P-cadherin (E-cadh, P-cadh) control tumor cell invasion, metastatic or stemness potential chemotherapy resistance. The study aimed to assess expression in breast cancer molecular subtypes.Immunohistochemistry for E-cadh P-cadh was performed 97 cases. Membrane (M), cytoplasmic (C) mixed (MC) patterns of were considered our evaluation.E-cadh C pattern significantly correlated the HER2 subtype (p=0.031). M highly specific (p=0.002). Only characterized triple negative (p=0.015). For...
Due to a high rate of transient human papillomavirus (HPV) infection, HPV genotyping has low specificity for high-grade cervical lesions, especially in young women. p16/Ki-67 dual immunohistochemical staining can also be used the detection oncogenic changes cells. Our aim was compare performance and lesions patients with atypical squamous cells undetermined significance (ASCUS)/low-grade intraepithelial lesion (LSIL) on Pap smear. We retrospectively analyzed 310 ASCUS/LSIL smear, who...
Background and Objectives: The objective of this study was to assess the effectiveness using a peri-cervical tourniquet in reducing blood loss during laparoscopic myomectomy. Materials Methods: This prospective evaluated impact performing concomitant placement myomectomy (LM). A total 60 patients were randomly allocated one two groups: 30 who underwent an LM with (the TLM group) benefited from standard SLM group). study's main evaluate use on perioperative loss, which is quantified as...