A5101895844- MicroRNA in disease regulation
- Iron Metabolism and Disorders
- Cardiac Valve Diseases and Treatments
- Molecular Biology Techniques and Applications
- Hemoglobinopathies and Related Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Forensic and Genetic Research
- Angiogenesis and VEGF in Cancer
- Prostate Cancer Treatment and Research
- Oral microbiology and periodontitis research
- Cardiovascular Issues in Pregnancy
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Bioinformatics and Genomic Networks
- Trace Elements in Health
- Aortic Disease and Treatment Approaches
- Biomedical Ethics and Regulation
- Pregnancy and preeclampsia studies
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Crystallography and molecular interactions
- Signaling Pathways in Disease
Victor Babeș University of Medicine and Pharmacy Timișoara
2016-2025
University of Chicago
2024
Resurrection Medical Center
2008
Significant progress was made in the understanding etiopathogenic factors related to MDD, including through research on role of micro RNAs (miRs). We investigated plasma miRs as potential markers for MDD patients treated with antidepressants.At initiation and at end twelve weeks treatment, blood samples were collected a structured diagnostic interview standardized depression rating scale presence severity major done. The average decrease HAMD score 76.89%. Plasma miR expression profiling...
Aortic stenosis (AS) often requires surgical aortic valve replacement (SAVR). Patient-prosthesis mismatch (PPM) can lead to suboptimal outcomes. Von Willebrand factor (VWF), crucial for hemostasis, is altered in AS patients. As part of an ongoing study, this research focuses on the impact PPM immediate postprocedural VWF levels SAVR patients, building upon our previous publication short-term dynamics and TAVR. This prospective study included 31 consecutive patients with severe undergoing...
Didilescu AC, Rusu D, Anghel A, Nica L, Iliescu Greabu M, Bancescu G, Stratul SI. Investigation of six selected bacterial species in endo‐periodontal lesions. International Endodontic Journal , 45 282–293, 2012. Abstract Aim To investigate and determine possible associations tested bacteria belonging to ‘orange’ ‘green’ complexes, lesions: Parvimonas micra, Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens Capnocytophaga sputigena . Methodology Forty‐six...
Chemokines are a family of small, structurally related cytokines with chemoattractant and activation properties. In breast cancer, both epithelial cancer cells within the microenvironment secrete chemokines either tumor-promoting or anti-malignant potential. The equilibrium between these two chemokine activities plays key role in biology developing tumor, including its ability to metastasize. Here we evaluated expression tumors plasma patients before treatment order identify blood-based...
In aged humans, stroke is a major cause of disability for which no neuroprotective measures are available. animal studies focal ischemia, short-term hypothermia often reduces infarct size. Nevertheless, efficient neuroprotection requires long-term, regulated lowering whole body temperature. Previously, we reported that post-stroke exposure to hydrogen sulfide (H2S) effectively lowers temperature and confers in animals.In the present study using behavioral tests, MRI, telemetrical EEG, BP...
Background and objectives: Thrombophilia in pregnant women is a condition whose incidence constantly increasing worldwide, and, under these conditions, the development of preventive procedures becoming essential. In this study, we aimed to evaluate thrombophilia western part Romania establish anthropometric characteristics, socioeconomic features, genetic risk factors. Material Methods: 178 were divided into three study groups, according type thrombophilia, aiming carry out profile acquired...
Aortic stenosis (AS) is a prevalent valvular disorder that poses significant burden on healthcare systems due to its debilitating symptoms and high mortality rates if left untreated. Surgical aortic valve replacement (SAVR) transcatheter (TAVR) are the primary interventions for severe AS, but perioperative complications such as bleeding remain concern. Von Willebrand factor (VWF), crucial player in hemostasis, known be altered AS may contribute hemostatic imbalance observed these patients....
The present clinical trial analyzed the safety of gene therapy using plasmidial constructs expressing vascular endothelial and hepatocyte growth factors in patients with critical limb ischemia. study included 43 patients: 29 treatment group 14 allocated to placebo group. primary end points were rate major amputations method. Secondary improvement pain at rest, walking ability ankle/brachial pressure index. overall amputation was 31.04% 71.42% (p=0.029). Pain rest improved 65% 7% (p=0.0006)....
Coronavirus disease is a global pandemic with millions of confirmed cases and hundreds thousands deaths worldwide that continues to create significant burden on the healthcare systems. The aim this study was determine patient clinical paraclinical profiles associate COVID-19 unfavourable outcome generate prediction model could separate between high-risk low-risk groups.The present multivariate observational retrospective study. A total 483 patients, residents municipality Timișoara, biggest...
Polymorphisms in estrogen receptor alpha gene (ESR1) have been previously associated with breast cancer risk; however, the results were not fully consistent. Our purpose was to study interactions between common genotypes ESR1, risk and tumor phenotypes. 6 ESR1 single nucleotide polymorphisms (SNPs) genotyped 103 patients 90 controls using hybridization probes; correlated known prognostic factors for 5 years-follow up data. To assess progesterone receptors (ER, PR) HER2/neu expressions,...