(1) Background: Osteogenesis imperfecta (OI) is a rare skeletal dysplasia characterized as heterogeneous disorder group with well-defined phenotypic and genetic features that share uncommon bone fragility. The current treatment options, medical orthopedic, are limited not efficient enough to improve the low density, fragility, growth, mobility of affected individuals, creating need for alternative therapeutic agents. (2) Methods: We searched database find papers regarding treatments OI other...

Hepatitis B virus (HBV) is a frequent cause of chronic hepatitis worldwide, with an estimated 5.6 million children under 5 years being infected. In Romania, there are no available epidemiology reports on large cohorts in children. We aimed to assess the profile pediatric HBV infection southern Romania. conducted observational retrospective study 506 HBV-infected Based alaninaminotransferase (ALT), serology and viremia, we identified four states disease. correlated age, gender, household...

The impact of the COVID-19 infection on athletes was reported to influence physical health, both decreasing performance and increasing risk injuries. This study aimed assess (maximal aerobic power, muscle function, speed) a group male adolescent soccer players before after compare effects nutrition intervention performance. included 99 players, between 13 15 years old, that had mild SARS-CoV-2 infection. Their evaluated in three periods (1 month 1 3 months infection). subjects were divided...

Patent ductus arteriosus (PDA) is common in newborns, being associated with high morbidity and mortality. While maternal neonatal conditions are known contributors, few studies use advanced machine learning (ML) as predictive factors. This study assessed how pathologies, medications, factors affect the risk of PDA using traditional statistics ML algorithms: Random Forest (RF) XGBoost (XGB). A retrospective 3 year cohort 201 NICU neonates Logistic regression (LR) chi-square analyses...

Background and Objectives: Patent ductus arteriosus (PDA) is common in newborns, being associated with high morbidity mortality. While maternal neonatal conditions are known contributors, few studies use advanced machine learning (ML) as predictive factors. This study assessed how pathologies, medications, factors affect the risk of PDA using traditional statistics ML algorithms: Random Forest (RF) XGBoost (XGB). Materials Methods: A retrospective 3-year cohort 201 NICU neonates Logistic...

Background Complete blood count, C-reactive protein and transaminases are routine laboratory parameters investigated in children with infections, including COVID 19. We aimed to evaluate the diagnostic accuracy of these diagnosed Methods At time admission, 19 suggestive symptoms were tested RT-PCR for SARS CoV-2 allocated either study group (RT-PCR positive) or control negative). All evaluated by complete CRP, transaminases. Results When comparing two groups, we identified significantly...

(1) Background: With an incidence of 4–10%, infantile hemangiomas (IH) are the most encountered benign tumors in infancy. Low birth weight (LBW), prematurity, female sex, multiple gestations, and family history IH some statistically proven risk factors for developing IH. The aim our study was to evaluate prevalence clinic its connection maternal perinatal factors. (2) Methods: We conducted a cross-sectional study, over three years (2020–2022), at Clinical Hospital Obstetrics Gynecology,...

The use of assisted reproductive technology has increased in Romania the past several years. Although most these pregnancies are uncomplicated, vitro fertilization is associated with an risk for adverse perinatal outcomes primarily caused by risks prematurity, gestational diabetes mellitus, and hypertensive disorders. Infertility can be a variety factors, including both male female some cases, cause remains unknown. In our clinic, etiology infertility was known cases equally distributed...

Background: Congenital heart defects (CHD) are a common type of internal birth defect affecting newborns globally, with prevalence ranging from 0.8% to 1.2% all live births. CHD significant cause morbidity and mortality in children worldwide. They can range severity simple complex that require multiple surgeries ongoing medical management. The rate for has decreased over the last decades due improved surgical techniques However, they still represent an important public health problem....

Congenital heart disease (CHD) is a prevalent congenital disorder diagnosed with high frequency, affecting approximately 0.8% to 1.2% of all live births. Research has demonstrated that the use pulse oximetry and clinical examination as screening tool for CHD diagnosis proven extremely valuable. We conducted retrospective longitudinal study over 3-year period involved 1188 newborns admitted NICU during first 72 hours life within this timeframe. 201 were CHD. Almost (n=198) had positive test...

Background: Assisted reproductive technology (ART) nowadays plays a major role in the treatment of infertility, with most frequently used techniques being vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). The objective this study is to analyze pregnancies achieved using these ART their correlations prematurity congenital malformations rates. Methods: This an observational retrospective longitudinal that includes 814 newborns conceived through ART, namely IVF or ICSI....

This is a case report of one-year-and-nine-month-old girl with multiple guttate psoriasis skin lesions, non-traumatic knee arthritis, and no family history autoimmune diseases. Laboratory tests revealed suggestive markers juvenile psoriatic arthritis (JPsA), while the dermatological examination described scaly erythematous lesions positive Auspitz sign. The diagnosis was confirmed by biopsy histopathological examination. were preceded onset within two weeks. negative history, age onset,...

Congenital heart disease (CHD) is diagnosed with high prevalence. Pulse oximetry and clinical examination are screening tools to aid in obtaining a CHD diagnosis. We conducted retrospective longitudinal study over three years, 1188 newborns admitted the neonatal intensive care unit (NICU) during first 72 hours of life. Two hundred one were CHD. Almost all (n=198) had positive test hours, while negative but later using echocardiography. The prevalence rate was 16.67%. A confusion matrix...

Extreme prematurity involves a series of complications that multidisciplinary team should manage. Taking into account the risks related to premature newborns, such as maternal-fetal infections, intrauterine growth restriction, and certain comorbidities associated with young gestational age, our objective is highlight importance in approaching cases an unfavorable prognosis. This case report extremely preterm newborn who came from high-risk pregnancy needed long-term hospitalization Neonatal...

Background: This research approaches chronic viral hepatitis in children from a multidisciplinary point of view, the disease being considered great burden. (2) Methods: We conducted 4-year observational prospective study, analyzing socio-economic status pediatric patients diagnosed with B or C. (3) Results: In total, 159 were included. Only 66% school-aged attending classes. Regarding monthly income per family, 49% had less than 1000 RON (5 = 1$), which 17% no income. The average years study...