A5031493059- Respiratory viral infections research
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- Infectious Encephalopathies and Encephalitis
- HIV/AIDS drug development and treatment
- Streptococcal Infections and Treatments
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- Rabies epidemiology and control
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Virology and Viral Diseases
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Parvovirus B19 Infection Studies
- Immunotherapy and Immune Responses
- Drug-Induced Adverse Reactions
- HIV-related health complications and treatments
- Neuroscience of respiration and sleep
- Liver Disease Diagnosis and Treatment
- Nosocomial Infections in ICU
National Institute of Research and Development for Biological Sciences
2013-2024
Carol Davila University of Medicine and Pharmacy
2013-2024
Avila University
2024
National Institute of Infectious Diseases
2020
Hepatitis B virus (HBV) is a frequent cause of chronic hepatitis worldwide, with an estimated 5.6 million children under 5 years being infected. In Romania, there are no available epidemiology reports on large cohorts in children. We aimed to assess the profile pediatric HBV infection southern Romania. conducted observational retrospective study 506 HBV-infected Based alaninaminotransferase (ALT), serology and viremia, we identified four states disease. correlated age, gender, household...
Our study describes the frequency and severity of COVID-19 in HCWs estimates dynamic risk COVID-19-related events. We actively surveyed all from a tertiary infectious disease hospital 26 February 2020 to 31 May 2023. Of 1220 HCWs, 62.9% (767) had at least one episode. The under 29 years (
In children, coronavirus disease 2019 (COVID-19) starts as a minor illness compared to adults, but during the ongoing COVID-19 pandemic, distinct SARS-CoV-2 variants and subvariants have changed options for therapies in both adults especially those with comorbidities such allergies. On 25 April 2022, Remdesivir (RDV), viral RNA-dependent RNA polymerase inhibitor, was approved by Food Drug Administration (FDA) treatment of pediatric patients 28 days older, weighing ≥3 kg, hospitalized or...
The 2022–2023 influenza season in Romania was characterized by high pediatric hospitalization rates, predominated due to A subtypes (H1N1) pdm09 and H3N2. lowered population immunity after the SARS-CoV-2 pandemic subsequent stoppage of circulation, particularly children who had limited pre-pandemic exposures, influenced among immunosuppressed patients with concurrent medical conditions are at an increased risk for developing severe forms influenza. This study focused on characteristics...
Background: Given the potential for additional development to clarify a better knowledge of generally influence COVID-19 upon pediatric population, clinical symptoms SARS-CoV-2 infection in children and adolescents are still being explored. Morbidity is characterized by variable course. Our study’s goal was compare aspects 230 patients who analyzed positive were hospitalized between April 2020 March 2022. Methods: This retrospective study aimed characteristics coronavirus disease 2019,...
Background: Given the potential for additional development to clarify a better knowledge of overall impact COVID-19 on pediatric population, clinical symptoms SARS-CoV-2 infection in children and adolescents are still being explored. Morbidity is characterized by variable course. Our study's goal was compare aspects 230 patients who tested positive were hospitalized between April 2020 March 2022. Methods: In retrospective analysis, we compared two groups infectious diseases ward IX at...
Chronic sclerosing sialadenitis (CSS), currently included in the group of immunoglobulin G4 (IgG4)-related diseases, is an under-recognized inflammatory lesion that afflicts mostly submandibular gland 40-60 years adults.To our knowledge, only one case CSS located has been reported childhood to date.We present a 5-year-old male child.He presented with bilateral swellings clinically resembled discrete lumps, suspected be tumors.The completely resected tumors composed predominantly dense...
During the coronavirus disease (COVID-19) pandemic healthcare workers (HCWs) acquired immunity by vaccination or exposure to multiple variants of severe acute respiratory syndrome 2 (SARS-CoV-2). Our study is a comparative analysis between subgroups HCWs constructed based on number SARS-CoV-2 infections, vaccination, and dominant variant in population. We collected analyzed data using χ2 test density incidence reinfections Microsoft Excel for Mac, Version 16.84, MedCalc®, 22.026. Of 829...
Antiviral therapy such as Oseltamivir has been recommended for hospitalized children with suspected and confirmed influenza almost 20 years. The is officially authorized newborns two weeks of age or older, however, questions about its safety effectiveness still surround it. Our goal was to assess the epidemiological features consecutive seasonal in-fluenza cases in following COVID-19 pandemic also observe clinical ef-fectiveness tolerability oseltamivir who were not vaccinated against had...
Antiviral therapy such as oseltamivir has been recommended for hospitalized children with suspected and confirmed influenza almost 20 years. The is officially authorized newborns two weeks of age or older, however, questions about its safety effectiveness still surround it. Our goals were to assess the epidemiological features consecutive seasonal cases in following COVID-19 pandemic; observe clinical tolerability who not vaccinated against had different subtypes, including A(H1N1), A(H3N2),...
We analysed the distribution of vaccine and non-vaccine Streptococcus pneumoniae serotypes antimicrobial susceptibility pneumococcal strains isolated from healthy Romanian children.A multi-centre cross-sectional study was performed in four counties to evaluate carried S. 2000 children aged 0-5 years.S. carriage detected 25.25% tested children. Carriage increased 16.7% among infants 29.4% 3-5-year-old (p<0.0001). The proportions included conjugate vaccines PCV7, PCV10, PCV13 our isolates were...
The study aims to describe the frequency of COVID-19 in healthcare workers (HCWs) a designated hospital for treatment Bucharest, Romania, and explore vaccination other factors associated with clinical outcome. We actively surveyed all HCWs from 26 February 2020 31 December 2021. Cases were laboratory-confirmed RT-PCR or rapid test antigen. Epidemiological, demographic, outcomes, status, co-morbidities data collected. Data analyzed using Microsoft Excel, SPSS, MedCalc. A total 490 cases...
Dendritic cells (DCs) are antigen-presenting with an important role in the innate and adaptive immune system. In skin lesions, cutaneous DCs (Langerhans cells, dermal plasmacytoid DCs) involved activation inflammatory benign as well malignant lymphoid proliferations. Density distribution of infiltrate can be helpful to differentiate benign, reactive from nature population. We performed a retrospective study including 149 patients: 35 mycosis fungoides, spongiotic dermatitis, psoriasis, lupus...
A large measles epidemic has been ongoing in Romania and many European countries, since 2016. We report case-based surveillance data for all patients (n = 1371) with laboratory-confirmed epidemiologically-confirmed hospitalized a major infectious diseases hospital Bucharest during the first three years of current (July 2016-July 2019). More than half (57.6%) had ages below 5 years; 6% 82) preexisting comorbidities. Only 1.5% fully vaccinated, 5.9% received only one vaccine dose, while 92.8%...
We retrospectively studied clinical features of the 2015-2016 paediatric influenza season and rate pneumococcal colonization/disease in a reference Romanian infectious diseases institute. Peak activity occurred between weeks 5-10/2016; A viruses initially predominated, switching to B after week 12/2016. Patients� median age was 4.4 years. Patients with were significantly younger compared (p[0.001), required longer hospitalization (p[0.001). S. pneumoniae identified 5.4% cases (only A),...
Difficulties in establishing the onset of neonatal sepsis has directed medical research recent years to possibility identifying early biological markers diagnosis. Overdiagnosing leads a higher rate and duration usage antibiotics Neonatal Intensive Care Unit (NICU), which term rise bacterial resistance, antibiotherapy complications, hospitalization costs.Concomitant analysis CRP (C Reactive Protein), procalcitonin, complete blood count, presepsin newborn babies with suspicion or late sepsis....
The 2022-2023 influenza season in Romania was characterized by high pediatric hospitalization rates, predominated A subtypes H1N1 and H3N2. Lowered population immunity to after the SARS-CoV-2 pandemic subsequent stoppage of circulation, particularly children who had limited pre-pandemic exposures, influenced among immunosuppressed, patients with concurrent medical conditions are at increased risk for developing severe forms influenza. This study focused on characteristics issues paediatric...
Results In the aforementioned period we registered 12 cases of bacterial brain abscesses in children. The female gender and 8 to 14 age group have prevailed. 50% presented a congenital heart defect, 25% untreated infections, 12.5% history craniocerebral injury no evident predisposing cause. onset consisted of: fever, vomiting, nausea, seizures, neurological problems. All required emergency neurosurgical treatment specific antibiotherapy. Before etiology infection was established, patients...
Tuberculosis is the primary cause of death due to infection in world. Identification
Pseudomonas aeruginosa is a Gram-negative bacillus, which can cause severe infections especially in immunocompromised patients. Most caused by this germ are nosocomial because of increased antibiotic and antiseptic resistance but rare cases we talk about community infections. Severe infection immunocompetent patients microbe extremely rare. The mortality rate sepsis P. very high (up to 60%).
Norovirus represents the most frequent cause of pediatric gastroenteritis requiring medical care. We conducted a prospective study on 276 patients admitted to tertiary hospital in Romania from January 2017 December 2019 estimate clinic-epidemiological and evolutionary impact infection. Among patients, median age was 2.34 years, 57.61% were male. The frequency hospitalizations year higher August, September, October, 72.1% urban areas. Diarrhea (92.58%), vomiting (83.33%), anorexia (92.03%),...