A comprehensive literature review was conducted with the aim of describing existing evidence and most recent therapeutic advancements. The phenotype hypertrophic cardiomyopathy is characterised by development concentric hypertrophy, which variable but often asymmetric, primarily occurring in left ventricle. disease marked diastolic dysfunction, a reduction intracavitary internal diameter, due to disordered positioning cardiomyocytes presence collagen fibres, thicken myocardial tissue impair...

A comprehensive literature review was conducted to summarise existing evidence and the latest therapeutic advancements in feline HCM. The disease phenotype is characterised by development of concentric hypertrophy, which variable but often asymmetric, primarily affecting left ventricle. HCM marked diastolic dysfunction, resulting a reduced intracavitary internal diameter due disordered alignment cardiomyocytes excessive collagen deposition, thickens myocardial tissue impairs relaxation....

CACNA1C ‐rs1006737 and ZNF804A ‐rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) bipolar disorder (BD), recently brain phenotypes. As these patients show abnormal verbal fluency (VF) related activation, we asked whether latter was affected by (alone in interaction)—to better understand how they might induce risk. We reported effects on functional VF‐related (for ‐rs1344706) structural both) connectivity. genotyped fMRI‐scanned 54 SCZ, 40 BD 80 controls...

Molecular analysis of 15 Brazilian infectious bronchitis virus (IBV) isolates, obtained from clinical outbreaks the disease in chickens (broilers or layers) state Minas Gerais (Brazil) between 1972 and 1989, is reported. Using N protein gene as target, IBVs were analyzed by reverse transcription-polymerase chain reaction/restriction fragment length polymorphism (RT-PCR/RFLP) with restriction enzymes AvaII, HphI, Sau96I, Tsp509I cDNA sequencing. Results those isolates compared to 19 sequences...

In the past years, knowledge of eosinophils playing a primary pathophysiologic role in several associated conditions has led to development biologics targeting therapies aiming at normalizing immune response, reducing chronic inflammation, and preventing tissue damage. To better illustrate potential relationship between different eosinophilic dysfunctions effects biological this scenario, here, we present case 63-year-old male first referred our department 2018 with diagnosis asthma,...

Introduction: Add-on biological monoclonal antibodies such as benralizumab (anti-IL-5Ra) are recommended by international guidelines to reduce exacerbations in severe eosinophilic asthma (SEA). However, few studies have assessed the impact of these therapies on lung function-related outcomes. Our goal was evaluate effectiveness function, including volumes and airway resistance, SEA patients Portugal. Methods: This a real-world, observational, prospective, multicentric study adult diagnosed...

Apesar de tratamento agressivo e atempado, a Sarcoidose pode ser, por vezes, uma doença progressiva bastante debilitante. O papel do factor necrose tumoral (TNF)-α na génese dos granulomas é ambíguo. Por um lado sua presença necessária para formação manutenção da inflamação granulomatosa, sendo, portanto, o seu antagonista utilizado com sucesso no doentes sarcoidose; outro outras situações, há referência aparecimento dessa patologia em submetidos Infliximab. Infliximab foi nós sarcoidose que...

A Diabetes mellitus é uma desordem metabólica com alta prevalência na população mundial. mais comum a diabetes do tipo 2, quando o corpo torna-se resistente à insulina ou não produz suficiente resultando em redução significativa da expectativa de vida além aumentar utilização dos serviços saúde. O autocuidado doença complicado pela falta adesão ao tratamento. educação permanente saúde surge neste contexto intuito provocar mudança atitudes e/ou comportamento permitindo aquisição novos...

Schizophrenia (SCZ) and bipolar disorder (BD) have high heritability. Genome-wide association studies (GWAS) identified ZNF804A as a significant risk gene for both illnesses. A validation of this finding at the brain systems-level is imperative there still little understanding how it heightens risk. Based in part on our recent findings an effect widespread decreased white matter microstructural fractional anisotropy (putatively proxy its integrity), particularly strong SCZ, we asked whether...

Objectives: Caring for the Caregiver (www.cuidardequemcuida.com) is a large community-based project that takes place in five Portuguese northern municipalities (EDV region) and aims to provide useful services informal carers within an integrative social-health approach.This presentation provides overview of its major intervention initiatives, efforts constraints providing such approach.A special focus played on psychoeducational program.Methods: A brief Project's main initiatives presented...

Objetivo: Relatar sentimentos vivenciados pelas mães no período puerperal enquanto recém-nascido está hospitalizado em Unidade de Terapia Intensiva Neonatal. Materiais e Métodos: Trata-se um estudo caráter descritivo, qualitativo. A população do presente foi composta por que estavam com seus filhos hospitalizados na Neonatal uma cidade Norte Minas Gerais. coleta dados realizada meio entrevista semiestruturada auxílio gravação áudio. Para análise dos utilizada a técnica Bardin, sendo...

Este artigo analisa a obra Canção para ninar menino grande (2022) de Conceição Evaristo, focalizando Fio Jasmim explorar expressão da masculinidade em meio expectativas patriarcais e normas gênero. Definimos como objetivo geral analisar expressa sob influência dessas normas, contribuindo reflexões sobre identidade masculina na sociedade contemporânea. De forma mais especifica, compreender as características culturais, históricas sociais associadas à negra influenciam percepção sedutor, bem...

A obesidade e o sobrepeso são de origem multifatoriais, caracterizados pelo acúmulo tecido adiposo que tangencia os valores referência para cada espécie, podendo desencadear alterações das funções fisiológicas. Este artigo revisão descreve as principais causas da do em cães, bem como fatores risco associados a essas condições. Foi feito levantamento bibliográfico nas bases dados eletrônicas SciELO, Medline, Web of Science Lilacs, busca livros periódicos. Os estudos selecionados abordavam...

O linfoma intravascular é uma forma muito rara de não Hodgkin células grandes B. Caracte-riza-se pela proliferação celular tumoral linfócitos limitada aos pequenos vasos, particularmente nos capilares. Apresentamos o caso doente 54 anos, fumadora, que foi admitida no nosso hospital para investigação um quadro com quatro meses evolução febre, sudorese nocturna, emagrecimento quantificado e dispneia progressiva. Ao exame objectivo apresentava-se febril, taquicárdica polipneica. Analiticamente,...

Neural Therapy is a type of treatment that based on the patient's life history, local anesthetics are applied in low concentrations, such as procaine hydrochloride or lidocaine, with objective body self-regulation and self-healing organism. In Brazil, it still little unknown, but extremely widespread countries like Germany, Argentina, Canada, Colombia, Spain, Switzerland. Various conditions intervertebral disc diseases can be treated. The aim this study was to report case female dog...

Pancreatitis, acute or chronic, is a serious disease for dogs, due to its harmful potential and the existence of underdiagnosis. The still target studies regarding pathophysiology therapeutic mechanisms, because signs presented by animals are nonspecific, ranging from mild severe presentations. It can cause morphofunctional changes in pancreas adjacent organs. diagnosis be very difficult task, either variable symptoms severity disease, impasses experienced at time complementary exams....