A5033330094- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Respiratory and Cough-Related Research
- Healthcare and Venom Research
- Autoimmune Bullous Skin Diseases
- Insect and Pesticide Research
- Eosinophilic Esophagitis
- Inhalation and Respiratory Drug Delivery
- Immunodeficiency and Autoimmune Disorders
- Entomological Studies and Ecology
- Pharmaceutical studies and practices
- Tracheal and airway disorders
- Mast cells and histamine
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Medical History and Innovations
- Dental Anxiety and Anesthesia Techniques
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
Hospital de Santa Maria
2012-2024
Centro Hospitalar Lisboa Norte
2012-2024
Instituto de Medicina Molecular João Lobo Antunes
2023
Hacettepe University
2023
Hospital San Juan de Dios
2021
University of Lisbon
1999-2019
Sociedade Portuguesa de Cardiologia
2018
Hospital Txagorritxu
2007-2008
Georgetown University
2003
Hospital de Santa Cruz
1992
IL-17 is a pro-inflammatory cytokine implicated in autoimmune and inflammatory conditions. The development/survival of IL-17-producing CD4 T cells (Th17) share critical cues with B-cell differentiation the circulating follicular helper subset was recently shown to be enriched Th17 able help differentiation. We investigated putative link between Th17-cell homeostasis B by studying compartment primary immunodeficiencies. Common Variable Immunodeficiency Disorders (CVID), defined defects into...
Summary Background Venom immunotherapy (VIT) induces long‐lasting immune tolerance to hymenoptera venom antigens, but the underlying mechanisms are not yet clarified. Regulatory T cells thought play an important role in allergic diseases and induction during specific immunotherapy. Aim Characterize longitudinally impact of VIT on pool circulating regulatory cells. Methods Fourteen venom‐allergic patients with severe reactions (grades III–IV) were studied before, 6 12 months after starting...
Common variable immunodeficiency disorders (CVID), the most frequent cause of symptomatic primary immunodeficiency, are defined by impaired antibody production. Notwithstanding, T cell activation and granulomatous manifestations represent main causes CVID morbidity even in patients receiving immunoglobulin (Ig) G replacement therapy. Additionally, gut pathology is a feature CVID. In this study, we investigated monocyte imbalances their possible relationship with increased microbial...
Venom-specific immunotherapy (VIT) is well recognized by its efficacy, and compelling evidence implicates regulatory T cells (Tregs) in the underlying tolerogenic mechanisms. Additionally, hymenoptera venom has for a long time been claimed to modulate immunity. Here, we investigated putative role of bee (Bv) human FOXP3-expressing Treg homeostasis differentiation, irrespective donors' allergic status. We found that Bv significantly enhanced differentiation both from conventional naïve CD4...
Background:The clinical and pathophysiological heterogeneity of atopic dermatitis (AD) endophenotypes is associated with wide diversity in response to therapy.The aim this study was evaluate the dupilumab a group AD patients identify clinical/immunological features different patterns response.Methods: A retrospective observational performed, including 30 adults who completed 12 months treatment dupilumab, Portuguese Immunoallergology Department.Demographic, clinical, immunological data were...
Background. Non-steroidal anti-inflammatory drugs (NSAID)/analgesics (paracetamol) are among the most common causes of drug hypersensitivity reactions in children, with a reported prevalence around 0.3% pediatric population. Paracetamol and ibuprofen commonly culprits Our objective was to describe allergy workup NSAID/paracetamol population monitored an outpatient clinic. Methods. Retrospective observational study by consulting medical records patients evaluated clinic history...
To the Editor, Hereditary angioedema (HAE) is a rare autosomal dominant disease, which mostly caused by reduced levels or dysfunctional activity of serine protease inhibitor C1-inhibitor (C1-INH) [1,2]. HAE patients present transient swelling episodes affecting subcutaneous and/or submucosal tissues, mainly involving skin, abdomen and upper respiratory tract, in some cases can be fatal [1–3]. Since symptoms recur with unpredictable frequency severity throughout patients' lives, effective...
La urticaria por frío (UF) es un tipo de crónica inducible (CIndU) donde aparecen ronchas pruriginosas recurrentes y/o angioedema tras la exposición a estímulos fríos. Aunque normalmente solo afecta áreas expuestas, pueden producirse reacciones sistémicas. Nuestro objetivo caracterizar los casos UF nuestro hospital. Estudio retrospectivo seguidos en nuestra consulta Portugal hasta octubre 2020. Se incluyeron 52 pacientes, ellos 40 mujeres. edad media fue 35 años. En 19 síntomas comenzaron...
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Background.Grass and olive pollens have overlapping pollination periods are common allergens in the Iberian Peninsula.Objective: To determine sensitization pattern to major Phleum pratense Olea europaea Portuguese population with pollen allergic rhinitis (AR) using molecular allergen diagnosis (MAD). Methods. Seasonal AR patients (≥ 12 years), positive skin prick tests (SPT) were recruited from 16 centers.Using ALEX 2 , specific IgE Phl p1, p2, p5, p6, p7, p 12, Ole e1, e7 e9...
Fundamentos: O angioedema hereditário (AEH) é uma doença rara. Os sintomas iniciam-se geralmente na infância/adolescência, mas a expressão clínica muito variável e está menos caraterizada nestas faixas etárias. Objetivos: Descrever série de doentes pediátricos com AEH seguidos num hospital terciário em Portugal. Métodos: Revisão dos processos clínicos entrevista telefónica aos familiares/cuidadores. Resultados: Incluídos 18 (12 famílias), idades 3-17 anos (mediana 12), 61% rapazes. Onze...