A5108059275- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Helicobacter pylori-related gastroenterology studies
- Autoimmune Bullous Skin Diseases
- Contact Dermatitis and Allergies
- Mast cells and histamine
- Eosinophilic Esophagitis
- Galectins and Cancer Biology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Antifungal resistance and susceptibility
- Bone health and osteoporosis research
- Fungal Infections and Studies
- Digestive system and related health
- Immunodeficiency and Autoimmune Disorders
- Bone health and treatments
- Infectious Diseases and Mycology
- Occupational exposure and asthma
- Healthcare Regulation
- Bone and Joint Diseases
- Veterinary medicine and infectious diseases
- Bone Metabolism and Diseases
Centro Hospitalar Lisboa Norte
2014-2024
University of Lisbon
2010-2024
Hospital de Santa Maria
2013-2023
Instituto de Medicina Molecular João Lobo Antunes
2023
Hospital da Senhora da Oliveira Guimarães
2023
Universidade do Porto
2015
Hôpital Necker-Enfants Malades
2013
Sorbonne Paris Cité
2013
Université Paris Cité
2013
Instituto de Medicina Tropical
2013
The aim of this study was to prospectively assess the pattern evolution primary resistance antibiotics in Helicobacter pylori strains isolated from Portuguese children over a 10 year period (2000–09). A total 1115 H. were tested for antibiotic susceptibility clarithromycin, metronidazole, amoxicillin, ciprofloxacin and tetracycline. adolescents [ages 4 months–18 years (mean age 10.17 ± 4.03 years)], comprising 562 (50.4%) boys 553 (49.6%) girls. Overall, rate 34.7% 13.9% metronidazole 4.6%...
Background:The clinical and pathophysiological heterogeneity of atopic dermatitis (AD) endophenotypes is associated with wide diversity in response to therapy.The aim this study was evaluate the dupilumab a group AD patients identify clinical/immunological features different patterns response.Methods: A retrospective observational performed, including 30 adults who completed 12 months treatment dupilumab, Portuguese Immunoallergology Department.Demographic, clinical, immunological data were...
Chlorhexidine is a commonly used antiseptic and disinfectant in the health-care setting. Anaphylaxis to chlorhexidine rare but potentially life-threatening complication. Epidemiologic data suggest that cases of allergy appears be increasing. In this article we report anaphylactic shock with cardiorespiratory arrest, during urethral catheterization due chlorhexidine. The authors also performed literature review PubMed library reports between 2014 2018, demonstrating increase number occurring...
Introduction.Adherence in allergen immunotherapy is crucial for its efficacy.At least 3 years of treatment are recommended achieving a long-term modifying effect.Objectives.To assess patient's adherence and to identify determinant factors subcutaneous (SCIT) suspension patients with respiratory allergy.Methods.Retrospective analysis the medical record submitted SCIT between January 2013 December 2016 our Department.Results.323 were included: 52% female; mean age 30 ± 13 years; average time...
Paediatric studies may provide important insights into the immunopathology of Helicobacter pylori-associated gastritis, as mucosal changes reflect different stages immunoinflammatory response. We characterized, by quantitative immunohistochemistry, gastric lymphocyte phenotype and HLA-DR antigen expression evaluated correlation with histopathology, in H. pylori-infected (Hp+ve) uninfected children (Hp-ve). In infected group, lamina propria CD3+ IgA plasmocyte cell numbers were significantly...
Oral Abstracts O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, J. Antoine, Munir Pirmohamed O2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence clinical picture? Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Yerly O3 Specific binding characteristics of HLA alleles associated...
Background. Eosinophil cationic protein (ECP) has been regarded as an excellent marker of eosinophil activation in various diseases where eosinophil‐mediated inflammation plays a role. Recently, it suggested faecal intestinal several immune‐mediated with gastrointestinal expression. Owing to the scarcity information at paediatric age, establishment reference values is necessary before further clinical studies. Objective. To determine and serum ECP levels healthy children their association...
Introduction. Severe systemic reactions (SR) to allergen subcutaneous immunotherapy (SCIT) are rare but local (LR) common. We aimed characterize the type of and safety profile. Methods. Retrospective analysis medical record from patients under SCIT between 2013-2016. Results. Total 7372 injections in 323 patients: 52% female; mean age 30 years (SD 13); treatment time 19 months 13). There were 57 (17.6% population, 70% female) with at least one adverse reaction, for 93 described (1.3%...
Protein-losing gastropathy is a rare entity. Unlike the disease in adults, it usually benign and self-limited children. The aetiological contribution of cytomegalovirus has been insufficiently documented immunological status patients was rarely described most reports. authors report an 11-year-old boy with generalised oedema hypoproteinemia. Upper endoscopy biopsies showed marked hypertrophy gastric folds foveolar hyperplasia involving body fundus. presence tissue well through identification...
Hereditary angioedema (HAE) poses a high burden of disease, being its epidemiological and clinical data heterogeneous among countries, with no recent published studies concerning Portuguese patients. Therefore, we aimed to raise awareness HAE contribute knowledge.
O Transtorno do Espectro Autista (TEA) é uma condição neurológica caracterizada por desafios na interação social e padrões comportamentais repetitivos. Nos últimos anos, observou-se um aumento significativo nos casos diagnosticados, levantando questões sobre fatores genéticos, ambientais mudanças critérios diagnósticos. Este estudo explora as razões trás desse aumento, incluindo alterações definição de TEA, maior conscientização pública avanços nas ferramentas diagnósticas. Também são...
Objetivo: Identificar a prevalência de constipação e os possíveis fatores associados esta condição clínica em idosos comunitários residentes Maceió, cidade da região Nordeste do Brasil. Materiais métodos: estudo transversal com pessoas idade ≥ 60 anos, ambos sexos, domiciliadas Maceió. Foram reunidas informações sociodemográficas, econômicas, condições saúde, capacidade cognitiva medidas antropométricas. O padrão evacuatório foi avaliado base nos critérios ROMA IV. Resultados: A encontrada...