A5085496537- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- Healthcare and Venom Research
- Immunodeficiency and Autoimmune Disorders
- Mast cells and histamine
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Respiratory and Cough-Related Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cystic Fibrosis Research Advances
- Long-Term Effects of COVID-19
- Religion and Society in Latin America
- Insect and Pesticide Research
- HIV/AIDS Research and Interventions
- Pharmacovigilance and Adverse Drug Reactions
- Pulmonary Hypertension Research and Treatments
- Toxin Mechanisms and Immunotoxins
University of Lisbon
2014-2024
Universidade do Vale do Itajaí
2024
Universidade Federal de Santa Catarina
2024
Instituto de Medicina Molecular João Lobo Antunes
2006-2020
Hospital de Santa Maria
2001-2017
Reproductive Medicine Institute
2009
Centro Hospitalar do Porto
2008
Hospital de Santo António
2008
Hospital de São Marcos
2007
Hospital Garcia de Orta
2006
SARS-CoV-2 has emerged as a human pathogen, causing clinical signs, from fever to pneumonia-COVID-19-but may remain mild or asymptomatic. To understand the continuing spread of virus, detect those who are and were infected, follow immune response longitudinally, reliable robust assays for detection immunological monitoring needed. We quantified IgM, IgG, IgA antibodies recognizing receptor-binding domain (RBD) Spike (S) protein over period 6 months following COVID-19 onset. report detailed...
IL-17 is a pro-inflammatory cytokine implicated in autoimmune and inflammatory conditions. The development/survival of IL-17-producing CD4 T cells (Th17) share critical cues with B-cell differentiation the circulating follicular helper subset was recently shown to be enriched Th17 able help differentiation. We investigated putative link between Th17-cell homeostasis B by studying compartment primary immunodeficiencies. Common Variable Immunodeficiency Disorders (CVID), defined defects into...
Basophil testing is the most effective single approach for diagnosing type-IIb autoimmune chronic spontaneous urticaria (TIIbaiCSU). A positive basophil test has been linked to long disease duration, higher activity, a poor response antihistamines and omalizumab, better cyclosporine fenebrutinib. As of now it unclear what other features are connected in (CSU). We aimed identify test-positive CSU patients. performed cross-sectional study 85 was done with activation (BAT) histamine release...
O cotidiano policial no Brasil, marcado por vivências de violência, gera impactos psicossociais graves nos profissionais, afetando a saúde física, mental e espiritual. Objetiva-se discutir assistência religiosa como um direito constitucional ferramenta para redução danos biopsicossociais, contribuindo qualidade vida dos policiais. Para tanto, proceder-se-á à pesquisa exploratória bibliográfica, fundamentada em teorias conceitos sociologia do trabalho, mental, espiritualidade sagrado, além...
Na relação entre as peculiaridades do cotidiano policial e os riscos psicossociais associados ao ambiente de trabalho das organizações policiais no Brasil, a assistência religiosa tem sido desenvolvida como possibilidade apoio para mitigar esses seus danos. Este artigo analisa estratégias práticas uma na redução dos efeitos nos integrantes, em face violências vivenciadas rotina policial. Como percurso metodológico, utilizou-se pesquisa bibliográfica, partir da abordagem teórica sociologia...
As micro e pequenas empresas (MPEs) desempenham um papel fundamental na economia global, sendo responsáveis pela geração de emprego renda. No entanto, essas enfrentam desafios relacionados à competitividade sustentabilidade, especialmente em mercados emergentes. A gestão estratégica surge como uma solução eficaz para superar barreiras, otimizando o planejamento a eficiência operacional. Este estudo tem objetivo investigar contribuição da crescimento sustentabilidade MPEs, com foco...
Summary Background Venom immunotherapy (VIT) induces long‐lasting immune tolerance to hymenoptera venom antigens, but the underlying mechanisms are not yet clarified. Regulatory T cells thought play an important role in allergic diseases and induction during specific immunotherapy. Aim Characterize longitudinally impact of VIT on pool circulating regulatory cells. Methods Fourteen venom‐allergic patients with severe reactions (grades III–IV) were studied before, 6 12 months after starting...
Common variable immunodeficiency disorders (CVID), the most frequent cause of symptomatic primary immunodeficiency, are defined by impaired antibody production. Notwithstanding, T cell activation and granulomatous manifestations represent main causes CVID morbidity even in patients receiving immunoglobulin (Ig) G replacement therapy. Additionally, gut pathology is a feature CVID. In this study, we investigated monocyte imbalances their possible relationship with increased microbial...
Experimental studies suggest inflammation can contribute to blood barrier disruption and brain injury in cerebral venous thrombosis (CVT). We aimed determine whether biomarkers of were associated with the evolution lesions, persistent occlusion or functional outcome patients CVT.Pathophysiology Venous Infarction-Prediction Infarction Recanalization CVT (PRIORITy-CVT) was a multicenter prospective cohort study newly diagnosed CVT. Evaluation neutrophil-to-lymphocyte ratio (NLR) C-reactive...
Venom-specific immunotherapy (VIT) is well recognized by its efficacy, and compelling evidence implicates regulatory T cells (Tregs) in the underlying tolerogenic mechanisms. Additionally, hymenoptera venom has for a long time been claimed to modulate immunity. Here, we investigated putative role of bee (Bv) human FOXP3-expressing Treg homeostasis differentiation, irrespective donors' allergic status. We found that Bv significantly enhanced differentiation both from conventional naïve CD4...
An important factor contributing to the variation in reef fish assemblages is diel cycle of constituting species. To study diurnal variations, visual censuses were carried out during day and night on a 5-year-old artificial coastal waters Algarve (southern Portugal). The consists 735 small cubic modules (2.7 m 3 each) distributed 21 groups. Counts made according fixed time schedule (7:00, 8:30, 10:00, 11:30, 14:30, 19:00, 20:30, 23:00 h) by scuba divers August 1995. A total 18 species...
Peach is a common food allergen source throughout Europe. The aim of this study was to characterize peach allergy in Portuguese patient population.Thirty peach-allergic patients confirmed by double-blind placebo-controlled challenges and 29 controls were included. All subjects completed standardized questionnaire regarding symptoms epidemiologic characteristics, skin prick tests with inhalant allergens foods as well specific IgE antibodies peach, recombinant rPru p 1, 3, 4 cross-reactive...
Cytostatics, mainly oxaliplatin, are widely used to treat oncological diseases. There has been an increase in hypersensitivity reactions these drugs, mostly IgE-mediated. Skin tests the main diagnostic method but they may induce irritant local and contamination by health care professionals. The goals of this work were evaluate contribution basophil activation test (BAT) as a tool for compare expression CD63 CD203c molecules. BAT was performed with oxaliplatin 6 patients previous documented 5...
The contribution of the decline in thymic activity for emergence autoimmunity is still debatable. Immune-competent adults submitted to complete thymectomy early life provide a unique model address this question. We applied here strict criteria identify lacking based on sjTREC levels, exclude rebound and/or ectopic thymuses. In agreement, they featured severe naïve CD4 T-cell depletion and contraction receptor diversity. Notwithstanding this, there was neither increased incidence autoimmune...
Abstract Background Autoimmune chronic spontaneous urticaria (CSU) is due to mast cell (MC)‐activating autoantibodies, which are screened for by the autologous serum skin test (ASST) and basophil tests (BTs). Many CSU patients positive in only one of these tests. How often this occurs why currently unknown. Objectives To characterize prevalence mismatched ASST BTs patients, investigate possible reasons mismatches. Methods We determined rates ASST+/BT− ASST−/BT+ mismatches published studies....
Abstract Background Elucidating mechanisms of brain damage in cerebral venous thrombosis (CVT) would be instrumental to develop targeted therapies and improve prognosis prediction. Matrix metalloproteinase-9 (MMP-9), a gelatinase that degrades major components the basal lamina, has been associated blood–brain barrier disruption. We aimed assess, patients with CVT, temporal change serum concentrations MMP-9 its association key imaging clinical outcomes. Methods Pathophysiology Venous...
Chlorhexidine is a commonly used antiseptic and disinfectant in the health-care setting. Anaphylaxis to chlorhexidine rare but potentially life-threatening complication. Epidemiologic data suggest that cases of allergy appears be increasing. In this article we report anaphylactic shock with cardiorespiratory arrest, during urethral catheterization due chlorhexidine. The authors also performed literature review PubMed library reports between 2014 2018, demonstrating increase number occurring...