Gospel Nwikue
A5087097721- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Asthma and respiratory diseases
University of Liverpool
2016-2023
High-mobility group box 1 (HMGB1) is a damage-associated molecular-pattern protein. Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are serious, immune-mediated skin-blistering conditions.To determine serum and/or blister-fluid total HMGB1 levels in SJS/TEN cohorts, and expression formalin-fixed, paraffin-embedded (FFPE) skin vs. healthy maculopapular exanthema (MPE) skin. Methods Serum was quantified Malawian nevirapine-induced hypersensitivity, Taiwanese Spanish cohorts....
Abstract Decreased epidermal high‐mobility group box 1 (HMGB1) expression is an early marker of injury in Stevens–Johnson syndrome/toxic necrolysis (SJS/TEN). Etanercept, anti‐tumor necrosis factor therapeutic, effective the treatment SJS/TEN. The objective was to characterize antitumor factor‐alpha (TNF‐α)‐mediated HMGB1 keratinocyte/epidermal release and etanercept modulation. from TNF‐α treated (± etanercept), or doxycycline‐inducible RIPK3 Bak‐expressing human keratinocyte cells (HaCaTs)...
Oral Abstracts O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, J. Antoine, Munir Pirmohamed O2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence clinical picture? Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Yerly O3 Specific binding characteristics of HLA alleles associated...
Stevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, severe, skin blistering conditions in which areas of die detach. They actually represent a single disease with spectrum severity: less than 10% body surface area detachment SJS more 30% TEN. It affects around 500 people the UK each year is most commonly caused by reaction to wide‐range prescribed drugs. This study brought together researchers patients from U.K., Spain, Taiwan U.S.A. aimed determine levels protein...