A5031005500- Drug-Induced Adverse Reactions
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Vitamin K Research Studies
- Allergic Rhinitis and Sensitization
- Pharmaceutical studies and practices
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Eosinophilic Esophagitis
- Chemotherapy-related skin toxicity
- Fungal Biology and Applications
- Blood Coagulation and Thrombosis Mechanisms
- Delphi Technique in Research
- Identification and Quantification in Food
- Insect Resistance and Genetics
- Occupational exposure and asthma
- Genetically Modified Organisms Research
- Respiratory and Cough-Related Research
- Oral Health Pathology and Treatment
- Hemophilia Treatment and Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intramuscular injections and effects
Hospital de Santo António
2023-2025
Centro Hospitalar do Porto
2023
Hospital de São João
2014-2020
Universidade Federal do Estado do Rio de Janeiro
2019
Hospital Regional Universitario de Málaga
2016
Izmir University
2016
Hospital Universitario La Paz
2016
Instituto de Investigación Biomédica de Málaga
2016
Universitat Politècnica de València
2016
Ege University
2016
Food allergies are the leading cause of anaphylaxis in children. Cofactors, such as exercise and non-steroidal anti-inflammatory drugs, may influence occurrence severity allergic reactions to food. However, despite their relevance, underlying mechanisms cofactor-enhanced food remain poorly understood. We report case a 12-year-old girl with mitochondrial DNA depletion syndrome who was referred an allergy appointment due suspected ibuprofen hypersensitivity. Detailed anamnesis, laboratory...
Human Immunodeficiency Virus (HIV)-positive patients treated with the antiretroviral drug abacavir (ABC) may develop a potentially fatal ABC-associated hypersensitivity syndrome (ABC-HS), typically characterized by fever, malaise, rash, vomiting/diarrhoea and/or dyspnoea/cough. ABC-HS has been strongly associated HLA-B*57:01 carriage and screening for this allele is recommended.To determine prevalence of to characterize suspected in adult HIV population from our hospital during 7-year...
Oral Abstracts O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, J. Antoine, Munir Pirmohamed O2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence clinical picture? Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Yerly O3 Specific binding characteristics of HLA alleles associated...
Melkersson-Rosenthal syndrome is a rare neuro-mucocutaneous disease with chronic intermittent course, characterized by classic triad of orofacial swelling, fissured tongue (lingua plicata) and facial paralysis.The authors describe the case an oligosymptomatic variant (lip involvement) childhood onset, whose diagnosis was only established at age 19 years.The syndrome's pathophysiology unclear treatment challenging; corticosteroid therapy mainstay associated clinical histological improvement.
The possibility to desensitize or induce a state of unresponsiveness drug that previously caused hypersensitivity reaction is crucial when no equally safe efficacious therapeutic alternative exists. authors report the case successful desensitization ganciclovir. Hospitalized HIV-infected woman, 49 years-old, with AIDS, presenting an active cytomegalovirus (CMV) gastrointestinal infection. On second day therapy intravenous ganciclovir (250 mg, q12h), patient developed isolated pruriginous...
Sulfite hypersensitivity (SH) may have different clinical presentations, ranging from mild cutaneous symptoms to anaphylaxis. Our aim was evaluate the prevalence and characteristics of individuals with suspected sulfite allergy in our Food Allergy Unit (FAU). Clinical files 335 patients referred FAU a Portuguese University Hospital for food allergic reactions between January 2010 April 2014 were retrospectively reviewed; those suspicion SH selected. Patients’ demographics, medical history...
Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101) P92 16 years of experience with proton pump inhibitors (PPIs) Javier Dionicio Elera, Cosmin Boteanu, Maria Aranzazu Jimenez Blanco, Rosario Gonzalez-Mendiola, Irene Carrasco García, Antonio Alvarez, Jose Julio Laguna Martinez P93 Allergy evaluation quinolone induced adverse reactions Jaume Martí Garrido, Carla Torán Barona, Carolina Perales Chorda, Ramón López Salgueiro, Miguel Díaz Palacios, Dolores Hernández...
Tree nuts and peanuts are among the major causes of food allergy (FA) in both children adults. Cross-reactivity is common different nuts, but may also occur with peanuts, although they unrelated foods. We aim to describe prevalence characteristics tree nut adults followed a University Hospital Allergy Department North Portugal. Medical records patients studied our Food Unit between Jan/2011 Dec/2013 were reviewed; 134 (55% male; median age 7y [IQR 3-13y]) 198 (24% 36y 27-46y]) for 194 315...
Beta-lactams (BL) are one of the most prescribed antibiotics (AB) class. They frequently implicated in hypersensitivity reactions (HSR), with common skin involvement. However, infectious conditions might also induce cutaneous lesions, especially children, and they constitute an important differential diagnosis to BL HSR. To characterize suspected HSR analyse prevalence allergic our study population. We retrospectively reviewed clinical data from all children (<18 years-old) referred...
<b>Background:</b> Forced expiratory flows at lower lung volumes might be more adequate detecting small airways involvement in early childhood asthma. <b>Aims:</b> To ascertain potential insights given by FEF<sub>25–75%</sub> and FEF<sub>75%</sub> measurements over FEV<sub>1</sub> FEV<sub>1</sub>/FVC young children functional assessment, as asthma predictors. <b>Methods:</b> Retrospective review of spirometry [with bronchodilation test after 400 µg salbutamol (BDT)], clinical data...
Hypersensitivity reactions (HR) to non-steroid anti-inflammatory drugs (NSAID) are frequent and usually related COX-1 inhibition mechanism. Selective COX-2 inhibitors (sCOX-2i) commonly safe alternatives. To describe 2 clinical cases of anaphylaxis sCOX-2i. Male, 40 years-old, non-atopic, who was hospitalized due anaphylactic shock (nausea, vomiting, dyspnea, hypoxia hypotension) 30 minutes after etoricoxib intake for low-back pain. He 6 months earlier acute respiratory insufficiency with...
<b><i>Introduction:</i></b> Acquired angioedema (AAE), a rare cause of adult-onset non-urticarial mucocutaneous angioedema, can present as acute abdomen, frequent complaint in the emergency room (ER), often leading to unnecessary and potentially harmful procedures. <b><i>Case Presentation:</i></b> We report 47-year-old hypertense male, controlled with an angiotensin converting enzyme inhibitor (ACEI), who presented ER progressively worsening...