A5071829094- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Drug-Induced Adverse Reactions
- Respiratory and Cough-Related Research
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- COVID-19 Clinical Research Studies
- Eosinophilic Esophagitis
- Air Quality and Health Impacts
- Occupational exposure and asthma
- Long-Term Effects of COVID-19
- Indoor Air Quality and Microbial Exposure
- IL-33, ST2, and ILC Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Telomeres, Telomerase, and Senescence
- Cardiovascular Health and Disease Prevention
- Pharmaceutical studies and practices
- Dermatology and Skin Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Olfactory and Sensory Function Studies
- Respiratory Support and Mechanisms
- Advanced Chemical Sensor Technologies
- Anesthesia and Sedative Agents
Hôpital Bichat-Claude-Bernard
2016-2025
Sorbonne Paris Cité
2024-2025
Université Paris Cité
2016-2025
Inserm
2016-2025
Université Claude Bernard Lyon 1
2007-2024
Assistance Publique – Hôpitaux de Paris
2007-2024
Université Paris-Saclay
2024
Institut Pasteur
2021-2024
Physiopathologie et Epidémiologie des Maladies Respiratoires
2019-2023
Délégation Paris 7
2014-2021
Quality of life has been found to be impaired both in patients with asthma and allergic rhinitis, but the relative burden these diseases not investigated. We analyzed answers SF-36 questionnaire from 850 subjects recruited two French centers participating European Community Re-spiratory Health Survey, a population-based study young adults. Both rhinitis were associated an impairment quality life. However, 78% asthmatics also had rhinitis. Subjects (n = 240) more likely than neither nor 349)...
Recent studies of children suggest that factors encountered in a farm environment might protect against the development allergy. However, it remains uncertain whether living on childhood is associated with decreased risk atopic diseases adulthood. We analyzed data from 6,251 randomly selected adults 20 to 44 yr age participating European Community Respiratory Health Survey (ECRHS). Subjects answered detailed questionnaire and underwent specific IgE measurements five allergens. After...
Co-existence of drug-specific IgE and IgG antibodies aggravates neuromuscular-blocking agent-induced anaphylaxis in humans.
The association of impaired pulmonary function with cardiovascular morbidity and mortality has been reported in several prospective studies. nature this the mechanisms underlying it are unknown. Both atherosclerosis central arterial stiffness might be involved. We recently reported, a 4-yr longitudinal study, that reduced lung predicts development carotid atherosclerotic plaques. In present we report associations aortic measurements. One hundred ninety-four men, aged 30 to 70 yr free...
BackgroundNeuromuscular blocking agents (NMBAs) are among the leading cause of perioperative anaphylaxis, and most these reactions IgE mediated. Allergic sensitisation induced by environmental exposure to other quaternary ammonium-containing compounds, such as pholcodine, has been suggested. The aim this study was assess relationship between pholcodine NMBA-related anaphylaxis.MethodsALPHO a multicentre case-control study, comparing within year before anaesthesia patients with anaphylaxis...
Neuromuscular blocking agents (NMBA) are responsible for most immediate hypersensitivity reactions during anesthesia, as a result of the presence quaternary ammonium ion. The aim this study was to evaluate diagnostic performance commercial immunoglobulin E (IgE) test (quaternary morphine [QAM]) diagnosing sensitivity NMBA.We tested 168 patients exposed NMBAs anesthesia. Of those patients, 54 had an uneventful procedure and 114 reactions, 57 positive skin tests administered NMBA, whereas...
Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal examined whether this is an aging or year-of-birth cohort effect.We sought to assess changes and total IgE levels European adults as they aged over 20-year period.Levels serum specific common aeroallergens (house dust mite, cat, grass) were measured 3206 from 25 centers the Community Respiratory Health Survey on 3 occasions 20 years. Changes analyzed by using regression analysis...
Nitrogen dioxide (NO2), a ubiquitous atmospheric pollutant, may enhance the asthmatic response to allergens through eosinophilic activation in airways. However, effect of NO2 on inflammation without allergen exposure is poorly studied.
Background: Seasonal allergic rhinitis could predispose to the development of chronic bronchial inflammation as observed in asthma. However, direct links between nasal inflammation, and airway responsiveness patients with seasonal without asthma are not fully understood. The aim this study was analyse changes induced by challenge outside pollen season rhinitis. Methods: Nine were evaluated after either grass pollens or placebo a randomized cross‐over double‐blinded trial. Nasal parameters...
Exposure to formaldehyde may lead exacerbation of asthma.Our aim in this study was investigate whether exposure a low level (500 microg/m(3)) enhances inhaled allergen responses.Twelve subjects with intermittent asthma and allergy pollen were exposed, at rest, double-blind crossover either or purified air for 60 min. The order air-only randomized, exposures separated by 2 weeks. We also performed an inhalation challenge after each exposure. Airway responsiveness methacholine lower airway...
Patients with a penicillin allergy label have an increased risk of surgical site infection. Although decision tree was published in 2019 to define which patients could benefit from direct cephalosporin use the perioperative setting, this strategy remains unvalidated. This consensus statement aimed adapt it based on expert cover persisting caveats and environment poor allergist resources. Perioperative antibiotic prophylaxis experts were invited participate. The Delphi method implemented...
Although H 1 antihistamine compounds (H ) are highly effective in the treatment of allergic rhinitis (AR), their role asthma is still controversial. Because a strong association between AR and bronchial hyperresponsiveness (BHR) has been reported, this study was designed to assess effect new anti histamine, cetirizine (C), on nonspecific BHR patients with AR. Twelve were included double‐blind, crossover, placebo‐controlled trial. All had positive skin tests for common allergens showed...
Background: Desloratadine is associated with decreased signs and symptoms improved nasal airflow in multiple clinical trials patients allergic rhinitis (AR). The effect of desloratadine on quality life (QOL) AR has not been widely reported to date. We compared the effects placebo QOL seasonal using validated, disease‐specific measures. Methods: This was a multicenter, double‐blind, randomized, parallel‐group study 5 mg or daily for 2 weeks symptomatic AR. assessed at baseline day 14...