A5013437156- Skin and Cellular Biology Research
- Vascular Malformations and Hemangiomas
- Genetic and rare skin diseases.
- Allergic Rhinitis and Sensitization
- Tumors and Oncological Cases
- Dermatology and Skin Diseases
- Dermatological and Skeletal Disorders
- Cancer and Skin Lesions
- Urticaria and Related Conditions
- Nail Diseases and Treatments
- Hair Growth and Disorders
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Vascular Malformations Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Teratomas and Epidermoid Cysts
- Dermatologic Treatments and Research
- Central Venous Catheters and Hemodialysis
- Mast cells and histamine
- Parvovirus B19 Infection Studies
- RNA regulation and disease
- Genomics and Rare Diseases
- Wnt/β-catenin signaling in development and cancer
- Retinal and Macular Surgery
- Lipid metabolism and biosynthesis
Centre Hospitalier Universitaire de Toulouse
2014-2025
Hôpital Larrey
2015-2024
Université Toulouse III - Paul Sabatier
2011-2024
Laboratoire National de Référence
2020
Weatherford College
2020
Laboratoire Epidémiologie et Analyses en Santé Publique : Risques, Maladies Chroniques et Handicaps
2019
Université de Toulouse
2013
Hôpital Purpan
2012
These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group European experts following systematic review current literature, an expert conference held in Toulouse 2016, and consensus on discussions. summarize evidence expert-based recommendations intend to help clinicians with these rare often complex diseases. comprise two sections. This is part two, covering complications particularities some forms ichthyosis.
These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group European experts following systematic review current literature, an expert conference held in Toulouse 2016 and consensus on discussions. They summarize evidence expert-based recommendations are intended to help clinicians with these rare often complex diseases. comprise two sections. This is part one, covering topical therapies, systemic psychosocial management, communicating...
Propranolol is now widely used to treat severe infantile haemangiomas (IHs). Very few cases of propranolol-resistant IH (PRIH) are mentioned in the literature.To describe characteristics PRIHs.A national, multicentre, retrospective, observational study was conducted from February 2011 December 2011. All patients with PRIH evaluated by members Groupe de Recherche Clinique en Dermatologie Pédiatrique 1 January 2007 were eligible.Among 1130 treated propranolol for haemangioma, 10 (0.9%) had...
Inherited ichthyoses represent a group of rare skin disorders characterized by scaling, hyperkeratosis and inconstant erythema, involving most the tegument. Epidemiology remains poorly described. This study aims to evaluate prevalence inherited ichthyosis (excluding very mild forms) its different clinical forms in France. Capture – recapture method was used for this study. According statistical requirements, 3 lists (reference/competence centres, French association patients with internet...
Background: Chronic idiopathic urticaria (CIU) impairs quality of life (QoL). Currently, no consensus exists regarding how second‐generation H 1 ‐antihistamines (proven to control CIU symptoms) should be taken long‐term: as daily treatment or only when symptoms return (PRN). We sought determine which regimen improves better maintains QoL in CIU: desloratadine (DL) PRN. Methods: Subjects with initially responding DL 5 mg/day for 4 weeks were randomized an additional 8 weeks, (arm 1:...
There is limited information regarding quality of life in patients with inherited ichthyosis.To identify factors influencing ichthyosis.The study used focus groups and involved adult suffering from ichthyosis three French hospital centres. Group discussions were conducted by two facilitators continued until data saturation was reached. The verbatim transcripts analysed independently investigators. Categories considered as key the modulation negotiated agreement obtained.Data reached after...
Moderate to severe ichthyosis is known have a significant impact on quality of life. A French national survey was performed describe in more detail how impacts the patients' lives. questionnaire specifically dedicated distributed patients followed hospital expert centres or members association patients. total 241 questionnaires were completed and returned (response ratio: 29% for children 71% adults). negative obvious terms domestic life (skin care, housework, clothing, etc.),...
In 2019, a group of experts published the first European guidelines for management congenital ichthyoses after multidisciplinary expert meeting held in 2016. An update these and literature search was planned every 5 years, given clinical, molecular therapeutic advances, including use biologic therapies. We present here updated that have been developed by reorganized international systematic review recent literature, discussions, consensus reached at an conference June 2023. The provide...
In 2019, a group of experts published the first European guidelines for management congenital ichthyoses after multidisciplinary expert meeting held in 2016. An update these and literature search was planned every 5 years, given clinical, molecular therapeutic advances, including use biologic therapies. We present here updated that have been developed by reorganized international systematic review recent literature, discussions, consensus reached at an conference June 2023. The provide...
Background: Desloratadine is associated with decreased signs and symptoms improved nasal airflow in multiple clinical trials patients allergic rhinitis (AR). The effect of desloratadine on quality life (QOL) AR has not been widely reported to date. We compared the effects placebo QOL seasonal using validated, disease‐specific measures. Methods: This was a multicenter, double‐blind, randomized, parallel‐group study 5 mg or daily for 2 weeks symptomatic AR. assessed at baseline day 14...
To assess the effect of desloratadine on quality life (QoL) in chronic idiopathic urticaria (CIU).Patients with a history CIU (pruritus and weals lasting = 6 weeks) were included this multicentre, randomized, double-blind placebo-controlled study that took place dermatology centres throughout France. During study, patients randomized to receive 5 mg daily or placebo for 42 days.Variation scores two QoL dermatology-specific tools between baseline day 42, French translation version Dermatology...
Neoangiogenesis occurs within days following laser treatment of port wine stains (PWS), and plays a central role in failures. Topical use timolol can significantly reduce the production vascular endothelial growth factor vitro, animal models.The aim this study was to assess efficacy topical combination with pulsed dye (PDL) treatment, compared PDL alone, for treating PWS.This prospective multicenter controlled trial performed children PWS face who had not previously received treatment. After...
To date, few studies have investigated serum vitamin D status in patients with inherited ichthyosis. The aim of this study was to determine the prevalence deficiency (defined as level <10 ng/mL) a French cohort and identify associated risk factors. This prospective observational performed hospital reference center expertise for rare skin diseases. Patients' clinical characteristics were recorded. Serum concentration 25-hydroxyvitamin parathyroid hormone determined. For deficiency, calcium,...
Symptoms of allergic rhinitis (AR), particularly nasal congestion, can impair quality-of-life (QoL). However, only a modest correlation exists between these symptoms and Rhinoconjunctivitis Quality Life Questionnaire (RQLQ) scores, suggesting that both be evaluated for complete assessment health.Subjects with > or =2-year history moderate-to-severe AR to dust mite cat dander were randomized desloratadine 5 mg/day (n = 293) placebo/day 291) 28 days. Primary endpoint was change from baseline...
Acitretin is the main retinoid used to treat severe inherited ichthyosis. Alternatives may be considered if it results ineffective or there are side-effects, for women of childbearing age. Our objective evaluation effects and tolerance alitretinoin. An observational retrospective multicentric study was designed analyse patients with ichthyosis treated by A total 13 were included, 11 whom receiving acitretin at inclusion. The reason switching alitretinoin a desire pregnancy, but also because...
Patients with Hailey-Hailey and Darier diseases present disabling inflammatory lesions located in large skin folds, which are often exacerbated or induced by sweating. Quality of life is highly impaired because pain recurrent infections. An improvement after botulinum toxin A injections has previously been reported some patients but no prospective interventional studies available. The aim this open-label, 6-month, pilot study (NCT02782702) was to evaluate the effectiveness safety for...
Oral propranolol is the gold standard to treat infantile hemangiomas. There better efficacy and a lower risk of sequelae if therapy started before end growth phase, but most children are referred too late. Herein, we report first study investigate delay its associated factors when referring infants with hemangiomas that need therapy.The primary objective was determine in referral (time between age at [first phone contact] optimal for (fixed 75 days). The second impact weighted delayed...
The aim of this study was to define the skin patterns at high risk for upper airway infantile haemangioma. A retrospective multicentre French observational conducted between January 2006 and 2015 all confirmed haemangioma were included. Thirty-eight patients with from 9 centres Thirty-one had a cutaneous or mucosal haemangioma: 21 location considered (large segmental mandibular haemangioma), 4 very mild facial involvement (lower lip S1 (frontotemporal segment according Haggstrom Frieden)) 6...