A5053839055- Vascular Malformations and Hemangiomas
- Vascular Malformations Diagnosis and Treatment
- Tumors and Oncological Cases
- Vascular Tumors and Angiosarcomas
- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Nail Diseases and Treatments
- Chronic Lymphocytic Leukemia Research
- Skin and Cellular Biology Research
- Histiocytic Disorders and Treatments
- Teratomas and Epidermoid Cysts
- Parvovirus B19 Infection Studies
- Vascular anomalies and interventions
- Autoimmune Bullous Skin Diseases
- Tuberous Sclerosis Complex Research
- Urticaria and Related Conditions
- Polyomavirus and related diseases
- Eosinophilic Disorders and Syndromes
- Dermatological and Skeletal Disorders
- Soft tissue tumor case studies
- Inflammasome and immune disorders
- Cardiac tumors and thrombi
Assistance Publique – Hôpitaux de Paris
2016-2025
Institut Necker Enfants Malades
2017-2025
Hôpital Lariboisière
2025
Hôpital Necker-Enfants Malades
2015-2024
Université Paris Cité
2014-2024
Expression Génétique Microbienne
2018-2024
Institut des Maladies Génétiques Imagine
2015-2024
Sorbonne Paris Cité
2014-2023
Inserm
2017-2023
Bordeaux Population Health
2023
Oral propranolol has been used to treat complicated infantile hemangiomas, although data from randomized, controlled trials inform its use are limited.
<h3>Importance</h3> Sirolimus is increasingly being used to treat various vascular anomalies, although evidence of its efficacy lacking. <h3>Objective</h3> To assess the and safety sirolimus for children with slow-flow malformations better delineate indications treatment. <h3>Design, Setting Participants</h3> This multicenter, open-label, observational-phase randomized clinical trial included 59 aged 6 18 years a malformation who were recruited between September 28, 2015, March 22, 2018, in...
Alplesib exerts therapeutic effects in a mouse model of lymphatic anomalies and six patients with malformations over 6 months’ treatment.
Propranolol is now widely used to treat severe infantile haemangiomas (IHs). Very few cases of propranolol-resistant IH (PRIH) are mentioned in the literature.To describe characteristics PRIHs.A national, multicentre, retrospective, observational study was conducted from February 2011 December 2011. All patients with PRIH evaluated by members Groupe de Recherche Clinique en Dermatologie Pédiatrique 1 January 2007 were eligible.Among 1130 treated propranolol for haemangioma, 10 (0.9%) had...
Abstract Background To determine and list the clinical pathological features of cutaneous hematologic diseases in childhood. Procedure We retrospectively analyzed data for 51 patients up to 15 years age, who presented with primary disorders according WHO‐EORTC classification, at Necker‐Enfants Malades Hospital, Paris, France, over a 17‐year period. The cases were classified into following diagnostic categories: CD30+ T‐cell lymphoproliferative (24) all consisting lymphomatoid papulosis (LyP,...
Objective: VASCERN (https://vascern.eu/) is the European Reference Network for Rare Multisystemic Vascular Diseases. VASCERN-VASCA working group within that focuses on study of vascular anomalies. One objectives this to establish patient pathways guide physicians toward efficient diagnostic and management measures. The pathway presented here focused capillary malformations (CMs). Methods: Nominal Group Technique, a structured variation small discussion was used. Two facilitators were...
We aimed to evaluate the contribution of early magnetic resonance imaging (MRI) for presymptomatic diagnosis Sturge-Weber syndrome (SWS) in infants with a facial port-wine birthmark (PWB).Asymptomatic PWB who performed first MRI scan before 3 months and second after 9 were included this study. Leptomeningeal enhancement on T1-weighted four indirect signs leptomeningeal angioma (choroid plexus enlargement, cerebral atrophy, signal inversion white matter T2 hyposignal, T1 hypersignal) screened...
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin. The epidemiological factors strongly associated with this are: age over 65 years, fair skin, chronic sun exposure and immune suppression. Data are sparse in literature many questions remain unanswered regarding diagnosis treatment tumor. To provide clinical practice guidelines for MCC. data were analyzed current American German compared. Consensus items between these two adopted as recommendations. Regarding discordant...
SIGNIFICANCEManaging extracranial arteriovenous malformations is challenging.Sirolimus (rapamycin) increasingly being used in all kinds of vascular anomalies.In this study, we report the largest series treated with sirolimus, which included 10 patients (7 children).Results suggest a poor efficacy sirolimus for condition, only partial response 50% patients, was transient and lasted several months 2 5 further worsening.Managing when surgery embolization are not advised.Because its...
To develop and validate a specific questionnaire to assess burden on families of children with infantile haemangioma (IH): the Haemangioma Family Burden (HFB). Items were generated from literature review verbatim report parents. Subsequently, study was implemented at Necker Hospital Pellegrin Children's for psychometric analysis. The HFB refined via item reduction according inter-question correlations, consensus among experts exploratory factor A 20-item questionnaire, grouped into 5...
Kasabach-Merritt phenomenon (KMP) is a rare life-threatening vascular condition of infancy. Prognosis factors and long-term follow-up data are lacking. We retrospectively analysed the records 24 infants (10 females, 14 males) treated for KMP in Department Dermatology Necker-Enfants Malades Hospital, Paris, France, from 1984 to 2012. Mean duration thrombocytopaenia (2,000-38,000 platelets/mm3, mean 10,500/µl) was 8.8 months (range 3 days-84 months), which correlated with tumour infiltration...
Slow-flow superficial vascular malformations (VMs) are rare congenital anomalies that can be responsible for pain and functional impairment. Currently, we have no guidelines their management, which involve physical bandages, sclerotherapy, surgery, anti-inflammatory or anti-coagulation drugs treatment. The natural history is progressive worsening. Mammalian target of rapamycin (mTOR) a serine/threonine kinase acts as master switch in cell proliferation, apoptosis, metabolism...
Multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT) is a recently described glucose transporter 1-negative multifocal vascular disorder significant morbidity and mortality. However, data are lacking on the clinical spectrum, long-term prognosis, treatment of MLT. It often confused infantile hemangioma, but conditions must be differentiated for appropriate assessment therapeutic management. Treatments MLT have been disappointing, treatments classically used hemangioma...