A5027741879- Neurological Disease Mechanisms and Treatments
- Pharmacogenetics and Drug Metabolism
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Inflammatory mediators and NSAID effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
Universidade Federal de Minas Gerais
2014-2022
German Centre for Cardiovascular Research
2021
Lung Institute
2018
Imperial College London
2018
Singapore Eye Research Institute
2018
University of Lausanne
2018
University of California, Los Angeles
2018
Agency for Science, Technology and Research
2018
Institute of Molecular and Cell Biology
2018
Nanyang Technological University
2018
Cyclooxygenase-2 (COX-2) is an inducible enzyme expressed in inflammation and cancer targeted by nonsteroidal anti-inflammatory drugs. COX-2 also constitutively discreet locations where its inhibition drives gastrointestinal cardiovascular/renal side effects. Constitutive expression the kidney regulates renal function blood flow; however, global relevance of versus other tissues to COX-2-dependent flow regulation not known. Here, we used a microsphere deposition technique pharmacological map...
Abstract Activation of the angiotensin (Ang)-converting enzyme (ACE) 2/Ang-(1-7)/MAS receptor pathway renin–angiotensin system (RAS) induces protective mechanisms in different diseases. Herein, we describe cardiovascular phenotype a new transgenic rat line (TG7371) that expresses an Ang-(1-7)-producing fusion protein. The transgene-specific mRNA and corresponding protein were shown to be present all evaluated tissues TG7371 with highest expression aorta brain. Plasma Ang-(1-7) levels,...
Stroke, a leading cause of mortality and disability, characterized by neuronal death, can be induced reduction or interruption blood flow. In this study, the role Alamandine, new peptide renin-angiotensin system, was evaluated in in-vitro in-vivo brain ischemia models.In model, hippocampal slices from male C57/Bl6 mice were placed glucose-free aCSF solution bubbled with 95% N2 5% CO2 to mimic ischemia. An Alamandine concentration-response curve generated evaluate cell damage, glutamatergic...
Angiotensin‐(1‐7) [(Ang‐(1‐7)] attenuates arterial hypertension and improves baroreflex control upon chronic infusion in the central nervous system. In present study we evaluated baseline levels, variability circadian pattern of blood pressure (BP) heart rate (HR), as well as, sensitivity level cardiac autonomic tone transgenic rats that exhibit increased expression Ang‐(1‐7) (TG) brain. Sprague‐Dawley (control group ‐ CTL) TG were instrumented with telemetry probe to measure BP...